Hypercoagulability in dogs with chronic enteropathy and association with serum albumin concentration

Dixon, A; Hall, EJ; Adamantos, S; Kathrani, A; McGrath, C; Black, V

Abstract

Background: Dogs with protein-losing enteropathy (PLE) are at risk of developing a hypercoagulable state, but the prevalence of hypercoagulability in dogs with chronic enteropathies (CE) and normal serum albumin concentration is unknown. Hypothesis: Dogs with CE are predisposed to a hypercoagulable state as assessed by thromboelastography (TEG) independent of serum albumin concentration. Methods: Dogs with chronic gastrointestinal signs from suspected inflammatory CE between 2017 and 2019 were included. Thirty-eight were evaluated; every dog had a CBC, serum biochemistry panel, and abdominal imaging performed. The Canine Inflammatory Bowel Disease Activity Index (CIBDAI) was calculated. Thromboelastography was performed at presentation, and reaction time (R), kinetic time (K), alpha-angle, maximal amplitude (MA), and global clot strength (G) were recorded. Dogs were considered hypercoagulable if the G value was >= 25% above the reference interval. Results: Seventeen of 38 (44.7%; 95% confidence interval [CI], 28.6-61.7%) dogs with CE were hypercoagulable. The G value did not differ between the 19 dogs with normal (>= 28 g/L) serum albumin concentrations (9.05 kdyn/cm(2); 95% CI, 7.26-10.84; SD 3.71) and 19 dogs with hypoalbuminemia (11.3 kdyn/cm(2); 95% CI, 9.04-13.6, SD; 4.7; P = .11). The G value was negatively correlated with hematocrit, serum albumin concentration, and duration of signs and positively correlated with age. Conclusions and Clinical Importance: Dogs with CE and normal serum albumin concentration can be hypercoagulable as measured by TEG.

Citation

Dixon, A., Hall, E., Adamantos, S., Kathrani, A., McGrath, C., & Black, V. (2021). Hypercoagulability in dogs with chronic enteropathy and association with serum albumin concentration. Journal of Veterinary Internal Medicine, 35(2), 860-866. https://doi.org/10.1111/jvim.16044

• Journal Article Type: Article
• Acceptance Date: Jan 14, 2021
• Publication Date: 2021
• Deposit Date: Dec 15, 2021
• Publicly Available Date: Dec 15, 2021
• Print ISSN: 0891-6640
• Publisher: Wiley Open Access
• Peer Reviewed: Peer Reviewed
• Volume: 35
• Issue: 2
• Pages: 860-866
• DOI: https://doi.org/10.1111/jvim.16044
• Keywords: canine; gastrointestinal thromboembolism; inflammation; thromboelastography
• Public URL: https://rvc-repository.worktribe.com/output/1553330