Repeat histopathology and culture of colonic biopsy specimens after treatment for Escherichia coli-associated granulomatous colitis in a cat

Waite, O; Yaffy, D; Kathrani, A

Abstract

Case summaryA 7.5-year-old neutered male Oriental Shorthair cat presented with an 8-month history of haematochezia, mucoid diarrhoea, tenesmus and vocalisation after a 4-year history of small bowel diarrhoea. Transabdominal ultrasonography confirmed diffuse colonic wall thickening and extensive ulceration and erythema after colonoscopy. Colonic histopathology confirmed periodic acid-Schiff positive macrophages, consistent with granulomatous colitis; Escherichia coli was cultured from colonic biopsy specimens. Fluorescent in situ hybridisation (FISH) identified intracellular E coli, and an 8-week oral course of marbofloxacin, a hydrolysed protein diet and a 5-day course of fenbendazole yielded a transient partial clinical remission of the colitis signs. A reported resolution in the small bowel signs was also reported. Colonoscopy was repeated 5 months later due to the recurrence of colitis signs. Histopathology was not consistent with granulomatous colitis supporting a complete remission; however, a chronic inflammatory enteropathy was confirmed with moderate lymphoplasmacytic, neutrophilic and eosinophilic colitis without a histiocytic component. E coli was again cultured from colonic biopsies with sensitivity to fluoroquinolones; FISH was positive for intracellular E coli. Clinical signs persisted despite a 2-week course of oral marbofloxacin. Relevance and novel informationE coli-associated granulomatous colitis is rare in cats. Colonic biopsy specimen culture is important to guide appropriate antibiotic therapy. Repeat histopathology, culture and FISH have not been previously reported after treatment of a cat with E coli-associated granulomatous colitis. Persistent clinical signs after treatment with oral marbofloxacin alongside a confirmed complete histologic remission support the presence of a concurrent chronic inflammatory enteropathy and pathology for the cat's ongoing colitis.

Citation

Waite, O., Yaffy, D., & Kathrani, A. (2023). Repeat histopathology and culture of colonic biopsy specimens after treatment for Escherichia coli-associated granulomatous colitis in a cat. Journal of Feline Medicine and Surgery Open Reports, 9(2), https://doi.org/10.1177/20551169231178442

• Journal Article Type: Article
• Acceptance Date: May 10, 2023
• Publication Date: Jul 4, 2023
• Deposit Date: Aug 1, 2023
• Publicly Available Date: Aug 1, 2023
• Publisher: SAGE Publications
• Peer Reviewed: Peer Reviewed
• Volume: 9
• Issue: 2
• DOI: https://doi.org/10.1177/20551169231178442
• Keywords: Chronic enteropathy; Escherichia coli; granulomatous colitis; marbofloxacin; remission; HISTIOCYTIC ULCERATIVE-COLITIS; DOGS