Pharmacological advances in mitochondrial therapy

Singh, A; Faccenda, D; Campanella, M

Abstract

Mitochondria play a vital role in cellular metabolism and are central mediator of intracellular signalling, cell differentiation, morphogenesis and demise. An increasingly higher number of pathologies is linked with mitochondrial dysfunction, which can arise from either genetic defects affecting core mitochondrial components or malfunctioning pathways impairing mitochondrial homeostasis. As such, mitochondria are considered an important target in several pathologies spanning from neoplastic to neurodegenerative diseases as well as metabolic syndromes. In this review we provide an overview of the state-of-the-art in mitochondrial pharmacology, focusing on the novel compounds that have been generated in the bid to correct mitochondrial aberrations. Our work aims to serve the scientific community working on translational medical science by highlighting the most promising pharmacological approaches to target mitochondrial dysfunction in disease. (C) 2021 The Authors. Published by Elsevier B.V.

Citation

Singh, A., Faccenda, D., & Campanella, M. (2021). Pharmacological advances in mitochondrial therapy. EBioMedicine, 65, https://doi.org/10.1016/j.ebiom.2021.103244

• Journal Article Type: Article
• Acceptance Date: Jan 29, 2021
• Publication Date: 2021
• Deposit Date: Dec 15, 2021
• Publicly Available Date: Dec 15, 2021
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 65
• DOI: https://doi.org/10.1016/j.ebiom.2021.103244
• Keywords: Mitochondrial diseases; Mitochondrial dysfunction in pathology; Mitochondria-targeted and untargeted agents; DISEASE
• Public URL: https://rvc-repository.worktribe.com/output/1553361