Hybridized Zoonotic Schistosoma Infections Result in Hybridized Morbidity Profiles: A Clinical Morbidity Study amongst Co-Infected Human Populations of Senegal

Fall, CB; Lambert, S; Leger, E; Yasenev, L; Garba, AD; Diop, SD; Borlase, A; Catalano, S; Faye, B; Walker, M; Sene, M; Webster, JP

Abstract

Hybridization of infectious agents is a major emerging public and veterinary health concern at the interface of evolution, epidemiology, and control. Whilst evidence of the extent of hybridization amongst parasites is increasing, their impact on morbidity remains largely unknown. This may be predicted to be particularly pertinent where parasites of animals with contrasting pathogenicity viably hybridize with human parasites. Recent research has revealed that viable zoonotic hybrids between human urogenital Schistosoma haematobium with intestinal Schistosoma species of livestock, notably Schistosoma bovis, can be highly prevalent across Africa and beyond. Examining human populations in Senegal, we found increased hepatic but decreased urogenital morbidity, and reduced improvement following treatment with praziquantel, in those infected with zoonotic hybrids compared to non-hybrids. Our results have implications for effective monitoring and evaluation of control programmes, and demonstrate for the first time the potential impact of parasite hybridizations on host morbidity.

Citation

Fall, C., Lambert, S., Leger, E., Yasenev, L., Garba, A., Diop, S., Borlase, A., Catalano, S., Faye, B., Walker, M., Sene, M., & Webster, J. (2021). Hybridized Zoonotic Schistosoma Infections Result in Hybridized Morbidity Profiles: A Clinical Morbidity Study amongst Co-Infected Human Populations of Senegal. Microorganisms, 9(8), https://doi.org/10.3390/microorganisms9081776

• Journal Article Type: Article
• Acceptance Date: Aug 17, 2021
• Publication Date: 2021
• Deposit Date: Jan 5, 2022
• Publicly Available Date: Jan 5, 2022
• Journal: Microorganisms
• Electronic ISSN: 2076-2607
• Publisher: MDPI
• Peer Reviewed: Peer Reviewed
• Volume: 9
• Issue: 8
• DOI: https://doi.org/10.3390/microorganisms9081776
• Keywords: hybridization; schistosomiasis; morbidity; ultrasonography; disease control; one health; HAEMATOBIUM INFECTIONS; MANSONI; EPIDEMIOLOGY; ULTRASOUND; PRAZIQUANTEL; EVOLUTION; DISEASE
• Public URL: https://rvc-repository.worktribe.com/output/1554136