B Temple
Effect of a 2+1 schedule of ten-valent versus 13-valent pneumococcal conjugate vaccine on pneumococcal carriage: Results from a randomised controlled trial in Vietnam
Temple, B; Nation, ML; Dai, VTT; Beissbarth, J; Bright, K; Dunne, EM; Hinds, J; Hoan, PT; Lai, JN; Nguyen, CD; Ortika, BD; Phan, TV; Thuy, HNL; Toan, NT; Uyen, DY; Satzke, C; Smith-Vaughan, H; Huu, TN; Mulholland, K
Authors
ML Nation
VTT Dai
J Beissbarth
K Bright
EM Dunne
J Hinds
PT Hoan
JN Lai
CD Nguyen
BD Ortika
TV Phan
HNL Thuy
NT Toan
DY Uyen
C Satzke
H Smith-Vaughan
TN Huu
K Mulholland
Abstract
Background: Pneumococcal conjugate vaccines (PCVs) generate herd protection by reducing nasopharyngeal (NP) carriage. Two PCVs, PCV10 and PCV13, have been in use for over a decade, yet there are few data comparing their impact on carriage. Here we report their effect on carriage in a 2+1 schedule, compared with each other and with unvaccinated controls. Methods: Data from four groups within a parallel, open-label randomised controlled trial in Ho Chi Minh City contribute to this article. Three groups were randomised to receive a 2+1 schedule of PCV10 (n = 250), a 2+1 schedule of PCV13 (n = 251), or two doses of PCV10 at 18 and 24 months (controls, n = 197). An additional group (n = 199) was recruited at 18 months to serve as controls from 18 to 24 months. NP swabs collected at 2, 6, 9, 12, 18, and 24 months were analysed (blinded) for pneumococcal carriage. This study aimed to determine if PCV10 and PCV13 have a differential effect on pneumococcal carriage, a secondary outcome of the trial. We also describe the serotype distribution among unvaccinated participants. Trial registration: ClinicalTrials. gov NCT01953510. Findings: Compared with unvaccinated controls, a 2+1 schedule of PCV10 reduced PCV10-type carriage by 45-62% from pre-booster through to 24 months of age, and a 2+1 schedule of PCV13 reduced PCV13-type carriage by 36-49% at 12 and 18 months of age. Compared directly with each other, there were few differences between the vaccines in their impact on carriage. Vaccine serotypes accounted for the majority of carriage in unvaccinated participants. Interpretation: Both PCV10 and PCV13 reduce the carriage of pneumococcal vaccine serotypes. The introduction of either vaccine would have the potential to generate significant herd protection in this population. (C) 2021 The Author(s). Published by Elsevier Ltd.
Citation
Temple, B., Nation, M., Dai, V., Beissbarth, J., Bright, K., Dunne, E., …Mulholland, K. (2021). Effect of a 2+1 schedule of ten-valent versus 13-valent pneumococcal conjugate vaccine on pneumococcal carriage: Results from a randomised controlled trial in Vietnam. Vaccine, 39(16), 2303-2310. https://doi.org/10.1016/j.vaccine.2021.02.043
Journal Article Type | Article |
---|---|
Acceptance Date | Feb 22, 2021 |
Publication Date | 2021 |
Deposit Date | Jan 11, 2022 |
Publicly Available Date | Jan 11, 2022 |
Print ISSN | 0264-410X |
Publisher | Elsevier |
Peer Reviewed | Peer Reviewed |
Volume | 39 |
Issue | 16 |
Pages | 2303-2310 |
DOI | https://doi.org/10.1016/j.vaccine.2021.02.043 |
Keywords | STREPTOCOCCUS-PNEUMONIAE; NASOPHARYNGEAL COLONIZATION; HAEMOPHILUS-INFLUENZAE; CHILDREN |
Public URL | https://rvc-repository.worktribe.com/output/1554942 |
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