Antibiotic usage practices and its drivers in commercial chicken production in Bangladesh

Chowdhury, Sukanta; Fournié, Guillaume; Blake, Damer; Henning, Joerg; Conway, Patricia; Hoque, Md. Ahasanul; Ghosh, Sumon; Parveen, Shahana; Biswas, Paritosh Kumar; Akhtar, Zubair; Islam, Khaleda; Islam, Md. Ariful; Rashid, Md. Mahbubur; Pelligand, Ludovic; Khan, Zobaidul Haque; Rahman, Mahmudur; Tomley, Fiona; Debnath, Nitish; Chowdhury, Fahmida

Abstract

Irrational and inappropriate use of antibiotics in commercial chicken production can contribute to the development of antimicrobial resistance. We aimed to assess antibiotic usage in commercial chicken production in Bangladesh, and identify factors associated with this practice. We conducted a large-scale cross-sectional study to collect information on antibiotic usage in commercial chickens from January to May 2021. Structured interviews were
conducted with 288 broiler, 288 layer and 192 Sonali (locally-produced cross-bred) farmers in 20 sub-districts across Bangladesh. The frequency of antibiotic usage, the types of antibiotics and purpose of usage were estimated for each production type. Adjusted odds ratios (aOR) were calculated to measure the association between antibiotic usage and factors related to the characteristics of the farms and farmers using multivariable logistic regression models. The proportion of farms, irrespective of their production type, reporting usage of antibiotics in the 24 hours preceding the interview was 41% (n = 314, 95% CI: 37–44%). Forty-five percent (n = 344, 41–48%) reported antibiotic usage in the last 72 hours, 86% (n = 658, 83–88%) in the last 14 days, and almost all farms, 98% (n = 753, 97–99%), had used antibiotics since the start of their production cycle. Use of antibiotics in the 24 hours preceding an interview was more frequently reported in broiler (OR 1.91, 95% CI: 1.36–2.69) and
Sonali (OR 1.94, 95% CI: 1.33–2.33) than layer farms. Oxytetracycline (23–31%, depending on production type), doxycycline (18–25%), ciprofloxacin (16–26%) and amoxicillin (16–44%) were the most frequently used antibiotics. Antibiotics were reported to be used for
both treatment and prophylactic purposes on most farms (57–67%). Usage of antibiotics in the 24h preceding an interview was significantly associated with the occurrence of any illnesses in chickens (aOR broiler: 41.22 [95% CI:13.63–124.62], layer: aOR 36.45[9.52– 139.43], Sonali: aOR 28.47[4.97–162.97]). Antibiotic usage was mainly advised by veterinary practitioners (45–71%, depending on production type), followed by feed dealers (21–40%) and farmers (7–13%). Improvement of chicken health through good farming practices along with changes in key stakeholders (feed dealers and practitioners) attitudes towards antibiotic recommendations to farmers, may help to reduce the levels of antibiotic usage and thus contribute to mitigate antimicrobial resistance

Citation

Chowdhury, S., Fournié, G., Blake, D., Henning, J., Conway, P., Hoque, M. A., Ghosh, S., Parveen, S., Biswas, P. K., Akhtar, Z., Islam, K., Islam, M. A., Rashid, M. M., Pelligand, L., Khan, Z. H., Rahman, M., Tomley, F., Debnath, N., & Chowdhury, F. (2022). Antibiotic usage practices and its drivers in commercial chicken production in Bangladesh. PLoS ONE, 17(10), e0276158. https://doi.org/10.1371/journal.pone.0276158

• Journal Article Type: Article
• Acceptance Date: Sep 30, 2022
• Online Publication Date: Oct 17, 2022
• Publication Date: Oct 17, 2022
• Deposit Date: Oct 18, 2022
• Publicly Available Date: Oct 24, 2022
• Journal: PLoS ONE
• Electronic ISSN: 1932-6203
• Publisher: Public Library of Science
• Peer Reviewed: Peer Reviewed
• Volume: 17
• Issue: 10
• Pages: e0276158
• DOI: https://doi.org/10.1371/journal.pone.0276158
• Keywords: Multidisciplinary
• Publisher URL: https://journals.plos.org/plosone/article/authors?id=10.1371/journal.pone.0276158