A Meta-Analysis to Estimate Prevalence of Resistance to Tetracyclines and Third Generation Cephalosporins in Enterobacteriaceae Isolated from Food Crops

Brunn, AA; Roustit, M; Kadri-Alabi, Z; Guardabassi, L; Waage, J

Abstract

Application of human and animal waste to fields and water sources and on-farm antimicrobial usage are documented contributors to the occurrence of antimicrobial resistance (AMR) in agricultural domains. This meta-analysis aimed to determine the prevalence of resistance to tetracycline (TET) and third generation cephalosporins (3GC) in Enterobacteriaceae isolated from food crops. TET was selected in view of its wide use in agriculture, whereas 3GC were selected because of the public health concerns of reported resistance to these critically important antibiotics in the environment. Forty-two studies from all six world regions published between 2010 and 2022 met the eligibility criteria. A random effects model estimated that 4.63% (95% CI: 2.57%, 7.18%; p-value: <0.0001) and 3.75% (95%CI: 2.13%, 5.74%; p-value: <0.0001) of surveyed food crops harboured Enterobacteriaceae resistant to TET and 3GC, respectively. No significant differences were observed between pre- and post-harvest stages of the value chain. 3GC resistance prevalence estimates in food crops were highest for the African region (6.59%; 95% CI: 2.41%, 12.40%; p-value: <0.0001) and lowest for Europe (1.84%; 95% CI: 0.00%, 6.02%; p-value: <0.0001). Considering the rare use of 3GC in agriculture, these results support its inclusion for AMR surveillance in food crops. Integrating food crops into One Health AMR surveillance using harmonized sampling methods could confirm trends highlighted here.

Citation

Brunn, A., Roustit, M., Kadri-Alabi, Z., Guardabassi, L., & Waage, J. (2022). A Meta-Analysis to Estimate Prevalence of Resistance to Tetracyclines and Third Generation Cephalosporins in Enterobacteriaceae Isolated from Food Crops. Antibiotics, 11(10), https://doi.org/10.3390/antibiotics11101424

• Journal Article Type: Article
• Acceptance Date: Oct 10, 2022
• Online Publication Date: Oct 17, 2022
• Publication Date: 2022
• Deposit Date: Aug 11, 2023
• Publicly Available Date: Aug 11, 2023
• Publisher: MDPI
• Peer Reviewed: Peer Reviewed
• Volume: 11
• Issue: 10
• DOI: https://doi.org/10.3390/antibiotics11101424
• Keywords: antimicrobial resistance; risk assessment; food value chains; food crops; agriculture; ESCHERICHIA-COLI O157H7; ANTIMICROBIAL RESISTANCE; ANTIBIOTIC-RESISTANCE; KLEBSIELLA-PNEUMONIAE; SALMONELLA SPP.; RAW VEGETABLES; FRESH PRODUCE; CHICKEN MEAT; LETTUCE