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Serum anti‐GM2 and anti‐GalNAc‐GD1a ganglioside IgG antibodies are biomarkers for immune‐mediated polyneuropathies in cats

Halstead, Susan K.; Jackson, Mark; Bianchi, Ezio; Rupp, Stefan; Granger, Nicolas; Menchetti, Marika; Galli, Greta; Freeman, Paul; Kaczmarska, Adriana; Bhatti, Sofie F.M.; Brocal, Josep; José‐López, Roberto; Tipold, Andrea; Quintana, Rodrigo Gutierrez; Ives, Edward J.; Liatis, Theofanis; Nessler, Jasmin; Rusbridge, Clare; Willison, Hugh J.; Rupp, Angie


Susan K. Halstead

Mark Jackson

Ezio Bianchi

Stefan Rupp

Nicolas Granger

Marika Menchetti

Greta Galli

Paul Freeman

Adriana Kaczmarska

Sofie F.M. Bhatti

Josep Brocal

Roberto José‐López

Andrea Tipold

Rodrigo Gutierrez Quintana

Edward J. Ives

Theofanis Liatis

Jasmin Nessler

Clare Rusbridge

Hugh J. Willison

Angie Rupp


Background and Aims
Recent work identified anti-GM2 and anti-GalNAc-GD1a IgG ganglioside antibodies as biomarkers in dogs clinically diagnosed with acute canine polyradiculoneuritis, in turn considered a canine equivalent of Guillain-Barré syndrome. This study aims to investigate the serum prevalence of similar antibodies in cats clinically diagnosed with immune-mediated polyneuropathies.

The sera from 41 cats clinically diagnosed with immune-mediated polyneuropathies (IPN), 9 cats with other neurological or neuromuscular disorders (ONM) and 46 neurologically normal cats (CTRL) were examined for the presence of IgG antibodies against glycolipids GM1, GM2, GD1a, GD1b, GalNAc-GD1a, GA1, SGPG, LM1, galactocerebroside and sulphatide.

A total of 29/41 IPN-cats had either anti-GM2 or anti-GalNAc-GD1a IgG antibodies, with 24/29 cats having both. Direct comparison of anti-GM2 (sensitivity: 70.7%; specificity: 78.2%) and anti-GalNAc-GD1a (sensitivity: 70.7%; specificity: 70.9%) antibodies narrowly showed anti-GM2 IgG antibodies to be the better marker for identifying IPN-cats when compared to the combined ONM and CTRL groups (p=0.049).

Anti-GA1 and/or anti-sulphatide IgG antibodies were ubiquitously present across all sample groups, whereas antibodies against GM1, GD1a, GD1b, SGPG, LM1 and galactocerebroside were overall only rarely observed.

Anti-GM2 and anti-GalNAc-GD1a IgG antibodies may serve as serum biomarkers for immune-mediated polyneuropathies in cats, as previously observed in dogs and humans.

This article is protected by copyright. All rights reserved.


Halstead, S. K., Jackson, M., Bianchi, E., Rupp, S., Granger, N., Menchetti, M., …Rupp, A. (2022). Serum anti‐GM2 and anti‐GalNAc‐GD1a ganglioside IgG antibodies are biomarkers for immune‐mediated polyneuropathies in cats. Journal of the Peripheral Nervous System,

Journal Article Type Article
Acceptance Date Dec 23, 2022
Online Publication Date Dec 27, 2022
Publication Date Dec 27, 2022
Deposit Date May 10, 2023
Publicly Available Date May 10, 2023
Journal Journal of the Peripheral Nervous System
Print ISSN 1085-9489
Electronic ISSN 1529-8027
Publisher Wiley
Peer Reviewed Peer Reviewed
Keywords Neurology (clinical); General Neuroscience
Additional Information Received: 2022-09-22; Accepted: 2022-12-23; Published: 2022-12-27


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