Natural Polymeric Composites Derived from Animals, Plants, and Microbes for Vaccine Delivery and Adjuvant Applications: A Review

Nordin, A; Husna, SMN; Ahmad, Z; Nordin, ML; Ilyas, RA; Azemi, AK; Ismail, N; Siti, NH; Ngadi, N; Azami, MSM; Norpi, ASM; Reduan, MFH; Osman, AY; Pratama, DAOA; Nabgan, W; Shaari, R

Abstract

A key element in ensuring successful immunization is the efficient delivery of vaccines. However, poor immunogenicity and adverse inflammatory immunogenic reactions make the establishment of an efficient vaccine delivery method a challenging task. The delivery of vaccines has been performed via a variety of delivery methods, including natural-polymer-based carriers that are relatively biocompatible and have low toxicity. The incorporation of adjuvants or antigens into biomaterial-based immunizations has demonstrated better immune response than formulations that just contain the antigen. This system may enable antigen-mediated immunogenicity and shelter and transport the cargo vaccine or antigen to the appropriate target organ. In this regard, this work reviews the recent applications of natural polymer composites from different sources, such as animals, plants, and microbes, in vaccine delivery systems.

Citation

Nordin, A., Husna, S., Ahmad, Z., Nordin, M., Ilyas, R., Azemi, A., …Shaari, R. (2023). Natural Polymeric Composites Derived from Animals, Plants, and Microbes for Vaccine Delivery and Adjuvant Applications: A Review. Gels, 9(3), https://doi.org/10.3390/gels9030227

• Journal Article Type: Article
• Acceptance Date: Mar 13, 2023
• Online Publication Date: Mar 15, 2023
• Publication Date: 2023
• Deposit Date: Feb 9, 2024
• Publicly Available Date: Feb 9, 2024
• Print ISSN: 2310-2861
• Publisher: MDPI
• Peer Reviewed: Peer Reviewed
• Volume: 9
• Issue: 3
• DOI: https://doi.org/10.3390/gels9030227
• Keywords: natural polymer; vaccine delivery; adjuvant; plant; animal; microbe; PROTEIN VACCINE; NANOPARTICLES; CHITOSAN; DNA; HYDROGEL; ANTIGEN; CELLS; MACROPHAGES; FORMULATION; ANTIBODIES