Causes of thrombocytopenia in dogs in the United Kingdom: A retrospective study of 762 cases

Frances, MMA; Seth, M; Sharman, M; Pollard, D; Ortiz, AL; Miller, R; Natsiopoulos, T; Walker, D; Jones, B; Hardwick, J; Glanemann, B; Garcia, AS; Bacon, J; Selgas, AG

Abstract

BackgroundThrombocytopenia is a common laboratory abnormality in dogs, and numerous diseases have been associated with its development. Estimates for the sensitivity and specificity of the degree of reduction of platelet concentration for the diagnosis of primary immune-mediated thrombocytopenia (pITP) have not been reported. ObjectivesTo report the prevalence of different causes of thrombocytopenia in dogs in the United Kingdom and to investigate the utility of platelet concentration to differentiate causes of thrombocytopenia. MethodsMedical records of 762 dogs with thrombocytopenia presented to seven referral hospitals from January 2017 to December 2018 were retrospectively reviewed. Cases were assigned into the following categories: pITP, infectious diseases, neoplasia, inflammatory/other immune-mediated disorders and miscellaneous causes. The prevalence of the different categories was estimated, and platelet concentrations were compared. Receiver-operating characteristic (ROC) curves were used to investigate the utility of platelet concentration to differentiate between causes of thrombocytopenia. ResultsThe most common disease category associated with thrombocytopenia was neoplasia (27.3%), followed by miscellaneous causes (26.9%), pITP (18.8%), inflammatory/immune-mediated disorders (14.4%) and infectious diseases (12.6%). Dogs with pITP had significantly lower platelet concentrations (median 8 x 10(9)/L, range: 0-70 x 10(9)/L) than dogs in the other four categories. Platelet concentration was useful for distinguishing pITP from other causes of thrombocytopenia (area under ROC curve = 0.89, 95% confidence interval 0.87, 0.92), with a platelet concentration <= 12 x 10(9)/L being 60% sensitive and 90% specific. ConclusionsSevere thrombocytopenia was highly specific for a diagnosis of pITP, which was more prevalent in this UK population of thrombocytopenic dogs compared with previous epidemiological studies. Conversely, the proportion of dogs with infectious diseases was lower than in previous reports from other locations.

Citation

Frances, M., Seth, M., Sharman, M., Pollard, D., Ortiz, A., Miller, R., …Selgas, A. (2023). Causes of thrombocytopenia in dogs in the United Kingdom: A retrospective study of 762 cases. Veterinary Medicine and Science, https://doi.org/10.1002/vms3.1091

• Journal Article Type: Article
• Acceptance Date: Jan 15, 2023
• Online Publication Date: May 22, 2023
• Publication Date: 2023
• Deposit Date: Feb 13, 2024
• Publicly Available Date: Feb 13, 2024
• Print ISSN: 2053-1095
• Publisher: Wiley Open Access
• Peer Reviewed: Peer Reviewed
• DOI: https://doi.org/10.1002/vms3.1091
• Keywords: canine; platelets; prevalence; thrombocytopenia; United Kingdom; PLATELET VOLUME; DISEASES; ASSAY