Urinary bladder hemangiosarcoma in a cat treated with partial cystectomy and adjuvant metronomic cyclophosphamide and thalidomide

McNally, Abigail; Rossanese, Matteo; Suárez‐Bonnet, Alejandro; Hardas, Alexandros; Yale, Andrew D.

Abstract

Visceral hemangiosarcomas (HSA) are rare in cats and typically associated with aggressive biologic behavior and poor prognosis. A 4-year-old male neutered domestic shorthair cat was presented with a 3-month history of hematuria and stranguria; ultrasonography identified a large bladder mass. Complete excision was achieved by partial cystectomy. Histopathology and immunohistochemistry for von Willebrand factor confirmed HSA. The cat was treated using adjuvant cyclophosphamide, thalidomide, and meloxicam for 8 months. Abdominal ultrasonography repeated at 2 months and computed tomography repeated at 5 and 19 months after diagnosis showed no evidence of local recurrence or metastasis. The cat was alive at last follow-up (896 days). Although the cat described in this report experienced a more favorable prognosis compared to other visceral HSA locations, additional cases are needed to further understand the biological behavior of bladder HSAs and guide treatment decisions.

Citation

McNally, A., Rossanese, M., Suárez‐Bonnet, A., Hardas, A., & Yale, A. D. (in press). Urinary bladder hemangiosarcoma in a cat treated with partial cystectomy and adjuvant metronomic cyclophosphamide and thalidomide. Journal of Veterinary Internal Medicine, https://doi.org/10.1111/jvim.16750

• Journal Article Type: Article
• Acceptance Date: May 9, 2023
• Online Publication Date: Jun 28, 2023
• Deposit Date: Jul 12, 2023
• Publicly Available Date: Jul 19, 2023
• Journal: Journal of Veterinary Internal Medicine
• Print ISSN: 0891-6640
• Electronic ISSN: 1939-1676
• Publisher: Wiley Open Access
• Peer Reviewed: Peer Reviewed
• DOI: https://doi.org/10.1111/jvim.16750
• Keywords: General Veterinary
• Additional Information: Received: 2022-11-29; Accepted: 2023-05-09; Published: 2023-06-28