Transsphenoidal hypophysectomy for the treatment of hypersomatotropism secondary to a pituitary somatotroph adenoma in a dog

Steele, Matthew M E; Lawson, S; Scudder, | Christopher; Watson, Alice H; Ho, Nicola T Z; Yaffy, Dylan; Batchelor, Daniel; Fenn, Joe

Abstract

Pituitary-dependent hypersomatotropism is rarely diagnosed in dogs and surgical treatment is not reported. A 6-year-10-month male neutered Patterdale Terrier presented with polyuria, polydipsia, progressive pharyngeal stertor, excessive hair growth and widened facial features and paws. Serum insulin-like growth factor-1 concentration via radioimmunoassay was consistent with hypersomatotropism (1783 ng/mL). A pituitary mass was identified on magnetic resonance and computed tomography imaging. Six weeks later, glucosuria, starved hyperglycemia and serum fructosamine above the reference range (467.6 μmol/L, RI 177-314) were documented , consistent with diabetes mellitus. Transsphenoidal hypophysectomy was performed under general anesthesia without complications. Pituitary histopathology identified an acidophil neoplasm, with positive immunostaining for growth hormone. Postoperatively, there was rapid resolution of clinical, biochemical and morphologic changes of hypersomatotropism with persistence of diabetes mellitus. This case demonstrates successful resolution of hypersomatotropism with ongoing diabetes melli-tus in a dog after surgical treatment by transsphenoidal hypophysectomy. K E Y W O R D S acromegaly, canine, endocrine, growth hormone, insulin-like growth factor-1, surgery

Citation

Steele, M. M. E., Lawson, S., Scudder, |. C., Watson, A. H., Ho, N. T. Z., Yaffy, D., …Fenn, J. (2023). Transsphenoidal hypophysectomy for the treatment of hypersomatotropism secondary to a pituitary somatotroph adenoma in a dog. Journal of Veterinary Internal Medicine, https://doi.org/10.1111/jvim.16929

• Journal Article Type: Article
• Acceptance Date: Oct 19, 2023
• Online Publication Date: Nov 2, 2023
• Publication Date: Nov 2, 2023
• Deposit Date: Jun 3, 2024
• Publicly Available Date: Jun 4, 2024
• Print ISSN: 0891-6640
• Publisher: Wiley Open Access
• Peer Reviewed: Peer Reviewed
• DOI: https://doi.org/10.1111/jvim.16929
• Publisher URL: http://doi.org/10.1111/jvim.16929