Topography of visual and somatosensory inputs to the pontine nuclei in zebra finches (Taeniopygia guttata)

Gaede, AH; Gutiérrez-Ibáñez, C; Wu, PH; Pilon, MC; Altshuler, DL; Wylie, DR

Abstract

Birds have a comprehensive network of sensorimotor projections extending from the forebrain and midbrain to the cerebellum via the pontine nuclei, but the organization of these circuits in the pons is not thoroughly described. Inputs to the pontine nuclei include two retinorecipient areas, nucleus lentiformis mesencephali (LM) and nucleus of the basal optic root (nBOR), which are important structures for analyzing optic flow. Other crucial regions for visuomotor control include the retinorecipient ventral lateral geniculate nucleus (GLv), and optic tectum (TeO). These visual areas, together with the somatosensory area of the anterior (rostral) Wulst, which is homologous to the primary somatosensory cortex in mammals, project to the medial and lateral pontine nuclei (PM, PL). In this study, we used injections of fluorescent tracers to study the organization of these visual and somatosensory inputs to the pontine nuclei in zebra finches. We found a topographic organization of inputs to PM and PL. The PM has a lateral subdivision that predominantly receives projections from the ipsilateral anterior Wulst. The medial PM receives bands of inputs from the ipsilateral GLv and the nucleus laminaris precommisulis, located medial to LM. We also found that the lateral PL receives a strong ipsilateral projection from TeO, while the medial PL and region between the PM and PL receive less prominent projections from nBOR, bilaterally. We discuss these results in the context of the organization of pontine inputs to the cerebellum and possible functional implications of diverse somato-motor and visuomotor inputs and parcellation in the pontine nuclei.

Citation

Gaede, A., Gutiérrez-Ibáñez, C., Wu, P., Pilon, M., Altshuler, D., & Wylie, D. (2023). Topography of visual and somatosensory inputs to the pontine nuclei in zebra finches (Taeniopygia guttata). Journal of Comparative Neurology, https://doi.org/10.1002/cne.25556

• Journal Article Type: Article
• Acceptance Date: Oct 17, 2023
• Online Publication Date: Nov 8, 2023
• Publication Date: 2023
• Deposit Date: Dec 20, 2023
• Publicly Available Date: Dec 20, 2023
• Print ISSN: 0021-9967
• Electronic ISSN: 1096-9861
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• DOI: https://doi.org/10.1002/cne.25556
• Keywords: avian; lentiformis mesencephali; nucleus of the basal optic root; optic tectum; pons; pretectum; RRID:SCR_013673; RRID:SCR_01419; somatosensory Wulst; PIGEON COLUMBA-LIVIA; BASAL OPTIC ROOT; LENTIFORMIS MESENCEPHALI; ELECTROPHYSIOLOGICAL INVESTIGATIONS; E