Mastocytosis in the skin in dogs: A multicentric case series

Wyatt, EK; Affolter, V; Borio, S; Guillen, A; Verganti, S; Murphy, S; Ballarini, D; Banovic, F; Schmidt, V; Tanis, JB

Abstract

Canine cutaneous mastocytosis (CM) is rare in contrast to canine mast cell tumours. In humans, CM commonly affects children and is usually indolent with possible spontaneous resolution. Systemic mastocytosis (SM) with bone marrow involvement typically affects adults, can have a poor outcome, and often includes skin lesions. 'Mastocytosis in the skin' (MIS) is the preferred term of skin lesions, if bone marrow evaluations are not available, which is often the cases in dogs. In human SM and CM, KIT mutations are often detected. The veterinary literature suggests clinical resemblances between human and canine MIS, but data is limited, and KIT mutations are rarely assessed. This retrospective study describes clinicopathological findings, treatment and outcome of 11 dogs with suspected MIS. Dogs with multiple mast cell tumours were excluded. Histopathology reports (n = 5) or slides (n = 6) were reviewed. KIT mutation analysis including exons 8, 9, 11, 14 and 17 were analysed in eight dogs. Median age at diagnosis was 4 years (range, 1-12). Typical clinical signs included multifocal to generalised nodules and papules. Histologically, skin lesions were characterised by dermal infiltration of well-differentiated mast cells. KIT mutations were detected in 3/8 dogs (exon 9: n = 2; exon 11: n = 1). One dog had mastocytaemia suggesting possible SM. Glucocorticoids were mostly successful with lesion improvement in all treated dogs (n = 8). This cohort highlights resemblances between human and canine MIS. Further studies are required to confirm these findings and establish diagnostic criteria for CM and MIS associated with SM in dogs.

Citation

Wyatt, E., Affolter, V., Borio, S., Guillen, A., Verganti, S., Murphy, S., Ballarini, D., Banovic, F., Schmidt, V., & Tanis, J. (2024). Mastocytosis in the skin in dogs: A multicentric case series. Veterinary and Comparative Oncology, https://doi.org/10.1111/vco.12962

• Journal Article Type: Article
• Acceptance Date: Jan 3, 2024
• Online Publication Date: Jan 20, 2024
• Publication Date: 2024
• Deposit Date: Feb 5, 2024
• Journal: Veterinary and Comparative Oncology
• Print ISSN: 1476-5810
• Electronic ISSN: 1476-5829
• Publisher: British Veterinary Oncology Study Group
• Peer Reviewed: Peer Reviewed
• DOI: https://doi.org/10.1111/vco.12962
• Keywords: canine; cutaneous mastocytosis; mast cell; mastocytosis in the skin; urticaria pigmentosa; MAST-CELL TUMORS; PIGMENTOSA-LIKE DISEASE; CUTANEOUS MASTOCYTOSIS; SYSTEMIC MASTOCYTOSIS; C-KIT; PEDIATRIC MASTOCYTOSIS; ONSET MASTOCYTOSIS; MULTIPLE; DOMAIN; TIME