Jonathan Elliott
Sodium glucose transporter 2 inhibitors: Will these drugs benefit non-diabetic veterinary patients with cardiac and kidney diseases?
Elliott, Jonathan; Oyama, Mark A.
Authors
Mark A. Oyama
Abstract
Abstract Sodium glucose transporter type 2 (SGLT2) inhibitors have been introduced into human medicine where their beneficial effects go beyond the expected improvement in blood glucose control. These drugs appear to prevent progression of both cardiovascular and kidney diseases, not only in diabetic but also in non-diabetic human patients. As these drugs have received conditional approval for use in diabetic cats and are being used in other veterinary species, the intriguing question as to whether they will have similar cardioprotective and nephroprotective effects in dogs and cats is being asked. The primary mechanism(s) by which SGLT2 inhibitors are cardio- and nephroprotective remain to be fully characterized. This paper reviews these suggested mechanisms in the context of the pathophysiology of progressive cardiovascular and kidney diseases in dogs and cats with the goal of predicting which categories of non-diabetic veterinary patients these drugs might be of most benefit.
Citation
Elliott, J., & Oyama, M. A. (2024). Sodium glucose transporter 2 inhibitors: Will these drugs benefit non-diabetic veterinary patients with cardiac and kidney diseases?. Journal of Veterinary Pharmacology and Therapeutics, n/a(n/a), https://doi.org/10.1111/jvp.13472
| Journal Article Type | Article |
|---|---|
| Acceptance Date | Jul 3, 2024 |
| Online Publication Date | Jul 13, 2024 |
| Publication Date | 2024 |
| Deposit Date | Aug 20, 2024 |
| Publicly Available Date | Aug 20, 2024 |
| Journal | Journal of Veterinary Pharmacology and Therapeutics |
| Print ISSN | 0140-7783 |
| Electronic ISSN | 1365-2885 |
| Publisher | American Academy of Veterinary Pharmacology and Therapeutics |
| Peer Reviewed | Peer Reviewed |
| Volume | n/a |
| Issue | n/a |
| DOI | https://doi.org/10.1111/jvp.13472 |
| Keywords | cardioprotection; cats; dogs; nephroprotection; tubuloglomerular feedback |
| Publisher URL | https://doi.org/10.1111/jvp.13472 |
Files
Sodium Glucose Transporter 2 Inhibitors: Will These Drugs Benefit Non-diabetic Veterinary Patients With Cardiac And Kidney Diseases?
(2.6 Mb)
PDF
Licence
http://creativecommons.org/licenses/by/4.0/
Publisher Licence URL
http://creativecommons.org/licenses/by/4.0/
Version
VoR
You might also like
Downloadable Citations
About RVC Repository
Administrator e-mail: publicationsrepos@rvc.ac.uk
This application uses the following open-source libraries:
SheetJS Community Edition
Apache License Version 2.0 (http://www.apache.org/licenses/)
PDF.js
Apache License Version 2.0 (http://www.apache.org/licenses/)
Font Awesome
SIL OFL 1.1 (http://scripts.sil.org/OFL)
MIT License (http://opensource.org/licenses/mit-license.html)
CC BY 3.0 ( http://creativecommons.org/licenses/by/3.0/)
Powered by Worktribe © 2025
Advanced Search