Treatment outcome of spontaneous chronic corneal epithelial defects in brachycephalic dogs comparing Boxers and non-Boxers: A retrospective multicenter study of 420 dogs

Goncalves, CAV; Oliver, JAC; Kafarnik, C; Garnett, KJ; Rushton, JO; Stravinskaite, V; Everson, R; Tee, F; Escribano-Bermejo, B; Tzouganakis, I; Lacerda, RP; Pearce, I; Fricker, GV

Abstract

Objective: To compare characteristics and treatment outcomes of spontaneous chronic corneal epithelial defects (SCCEDs) in brachycephalic non-Boxers and Boxers. We hypothesized that brachycephalic non-Boxers develop SCCEDs at a younger age and develop complications more frequently than Boxers. Animals Studied: Retrospective review of medical records of brachycephalic dogs treated for SCCEDs between January 2018 and December 2022 in multiple ophthalmology referral centers in the UK. Procedure: Data recorded included breed, age, time of onset, treatment prior to referral, treatment at referral, time to heal, need for further procedures, and complications. Results: A total of 464 SCCEDs in 420 dogs were included composed of 173 Boxers with 200 SCCEDs and 247 brachycephalic non-Boxer dogs with 264 SCCEDs. Boxers were significantly older (median 8.2, range 4.5-12.7 years) than brachycephalic non-Boxers (median 7.2, range 1.6-15.9 years) (p < .001). The first treatment (cotton-tipped applicator [CTA] debridement, diamond burr debridement, superficial keratectomy, grid keratotomy, punctate keratotomy, or combinations of these) selected was significantly different between groups (p < .001). Healing, excluding cases addressed by CTA debridement, following the first procedure was significantly more successful in Boxers (p = .049). Excluding cases addressed by CTA debridement, 9.6% of SCCEDs in Boxers (20/200) and 13.4% (32/239) of non-Boxers required more than one procedure. In the non-Boxer group, 9.5% (25/264) developed complications, contrasting with 4% (8/200) in the Boxer group. Non-Boxers were more likely to develop complications after the first treatment (p = .006). Conclusion: Non-Boxer brachycephalic dogs develop SCCEDs younger than Boxers. This study suggests SCCEDs in brachycephalic non-Boxers may be less likely to heal following one mechanical treatment and are more likely to develop complications.

Citation

Goncalves, C., Oliver, J., Kafarnik, C., Garnett, K., Rushton, J., Stravinskaite, V., Everson, R., Tee, F., Escribano-Bermejo, B., Tzouganakis, I., Lacerda, R., Pearce, I., & Fricker, G. (2024). Treatment outcome of spontaneous chronic corneal epithelial defects in brachycephalic dogs comparing Boxers and non-Boxers: A retrospective multicenter study of 420 dogs. Veterinary Ophthalmology, https://doi.org/10.1111/vop.13269

• Journal Article Type: Other
• Acceptance Date: Aug 8, 2024
• Online Publication Date: Aug 19, 2024
• Publication Date: 2024
• Deposit Date: Aug 27, 2024
• Print ISSN: 1463-5216
• Electronic ISSN: 1463-5224
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• DOI: https://doi.org/10.1111/vop.13269
• Keywords: Boxer; canine; small brachycephalic; spontaneous chronic corneal epithelial defects; DIAMOND-BURR DEBRIDEMENT; SCCEDS