Single-cell transcriptomic analysis of canine insulinoma reveals distinct sub-populations of insulin-expressing cancer cells

Wallace, M. D.; Herrtage, M. E.; Gostelow, R.; Owen, L.; Rutherford, L.; Hughes, K.; Denyer, A.; Catchpole, B.; O’Callaghan, C. A.; Davison, L. J.

doi:10.1186/s44356-025-00026-3

Single-cell transcriptomic analysis of canine insulinoma reveals distinct sub-populations of insulin-expressing cancer cells

Wallace, M. D.; Herrtage, M. E.; Gostelow, R.; Owen, L.; Rutherford, L.; Hughes, K.; Denyer, A.; Catchpole, B.; O’Callaghan, C. A.; Davison, L. J.

Authors

M. D. Wallace

M. E. Herrtage

R. Gostelow

L. Owen

L. Rutherford

K. Hughes

A. Denyer

B. Catchpole

C. A. O’Callaghan

L. J. Davison

Citation

Wallace, M. D., Herrtage, M. E., Gostelow, R., Owen, L., Rutherford, L., Hughes, K., Denyer, A., Catchpole, B., O’Callaghan, C. A., & Davison, L. J. (2025). Single-cell transcriptomic analysis of canine insulinoma reveals distinct sub-populations of insulin-expressing cancer cells. Veterinary Oncology, 2(1), https://doi.org/10.1186/s44356-025-00026-3

Journal Article Type	Article
Acceptance Date	Mar 24, 2025
Online Publication Date	May 26, 2025
Publication Date	May 26, 2025
Deposit Date	May 28, 2025
Publicly Available Date	Jun 5, 2025
Journal	Veterinary Oncology
Print ISSN	3004-9814
Electronic ISSN	3004-9814
Publisher	BioMed Central
Peer Reviewed	Peer Reviewed
Volume	2
Issue	1
DOI	https://doi.org/10.1186/s44356-025-00026-3
Additional Information	Received: 19 January 2025; Accepted: 24 March 2025; First Online: 26 May 2025; : ; : Ethical approval for archiving and use of residual insulinoma tissue with informed owner consent was provided from the University of Cambridge Department of Veterinary Medicine Ethics Review Committee and the Royal Veterinary College Clinical Research Ethics Review Board. This study did not impact on patient management.; : Not applicable.; : The authors declare no competing interests.