Evidence suggesting that microglia make amyloid from neuronally expressed APP: a hypothesis

Hardy, J; Lewis, P

Abstract

While APP is largely neuonally expressed, A beta amyloid is largely produced by microglia as the clearance mechanisms for damaged membranes becomes overwhelmed.

Citation

Hardy, J., & Lewis, P. (2025). Evidence suggesting that microglia make amyloid from neuronally expressed APP: a hypothesis. Molecular Neurodegeneration, 20(1), https://doi.org/10.1186/s13024-025-00847-8

• Journal Article Type: Article
• Acceptance Date: Apr 17, 2025
• Online Publication Date: May 9, 2025
• Publication Date: 2025
• Deposit Date: Jun 10, 2025
• Publicly Available Date: Jun 10, 2025
• Print ISSN: 1750-1326
• Electronic ISSN: 1750-1326
• Publisher: BioMed Central
• Peer Reviewed: Peer Reviewed
• Volume: 20
• Issue: 1
• DOI: https://doi.org/10.1186/s13024-025-00847-8
• Keywords: ALZHEIMERS-DISEASE; BETA; APOE