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A muscle growth-promoting treatment based on the attenuation of activin/myostatin signalling results in long-term testicular abnormalities (2021)
Journal Article
Vaughan, D., Mitchell, R., Kretz, O., Chambers, D., Lalowski, M., Amthor, H., …Patel, K. (2021). A muscle growth-promoting treatment based on the attenuation of activin/myostatin signalling results in long-term testicular abnormalities. Disease Models and Mechanisms, 14(2), https://doi.org/10.1242/dmm.047555

Activin/myostatin signalling acts to induce skeletal muscle atrophy in adult mammals by inhibiting protein synthesis as well as promoting protein and organelle turnover. Numerous strategies have been successfully developed to attenuate the signalling... Read More about A muscle growth-promoting treatment based on the attenuation of activin/myostatin signalling results in long-term testicular abnormalities.

The Role Of Fstl3 In Spermatogenesis: A Transcriptome Analysis (2019)
Journal Article
Ballesteros, R., Xia, D., O'Shaughnessy, P., & Mukherjee, A. (2019). The Role Of Fstl3 In Spermatogenesis: A Transcriptome Analysis. https://doi.org/10.1210/js.2019-SUN-218

Spermatogenesis in mammals depends on the function of Sertoli cells (SC). The total number of SC present in the testes is determined in the pre-pubertal stages of development. Activin, a TGFβ family ligand, regulates SC proliferation in the early pos... Read More about The Role Of Fstl3 In Spermatogenesis: A Transcriptome Analysis.

SMAD1/5 signaling in the early equine placenta regulates trophoblast differentiation and chorionic gonadotropin secretion (2014)
Journal Article
Cabrera-Sharp, V., Read, J. E., Richardson, S., Kowalski, A. A., Antczak, D. F., Cartwright, J. E., …De Mestre, A. M. (2014). SMAD1/5 signaling in the early equine placenta regulates trophoblast differentiation and chorionic gonadotropin secretion. Endocrinology, 155(8), 3054-64. https://doi.org/10.1210/en.2013-2116

TGFβ superfamily proteins, acting via SMAD (Sma- and Mad-related protein)2/3 pathways, regulate placental function; however, the role of SMAD1/5/8 pathway in the placenta is unknown. This study investigated the functional role of bone morphogenetic p... Read More about SMAD1/5 signaling in the early equine placenta regulates trophoblast differentiation and chorionic gonadotropin secretion.

Homologous and heterologous desensitization of guanylyl cyclase-B signaling in GH3 somatolactotropes (2014)
Journal Article
Thompson, I. R., Mirczuk, S. M., Smith, L., Lessey, A. J., Simbi, B., Sunters, A., …Fowkes, R. C. (2014). Homologous and heterologous desensitization of guanylyl cyclase-B signaling in GH3 somatolactotropes. Cell and Tissue Research, 355(2), 425-36. https://doi.org/10.1007/s00441-013-1763-y

The guanylyl cyclases, GC-A and GC-B, are selective receptors for atrial and C-type natriuretic peptides (ANP and CNP, respectively). In the anterior pituitary, CNP and GC-B are major regulators of cGMP production in gonadotropes and yet mouse models... Read More about Homologous and heterologous desensitization of guanylyl cyclase-B signaling in GH3 somatolactotropes.

Follistatin-like 3 (FSTL3) mediated silencing of transforming growth factor ß (TGFß) signaling is essential for testicular aging and regulating testis size
Journal Article
Oldknow, K. J., Seebacher, J., Goswami, T., Villen, J., Pitsillides, A. A., O'Shaughnessy, P. J., …Mukherjee, A. Follistatin-like 3 (FSTL3) mediated silencing of transforming growth factor ß (TGFß) signaling is essential for testicular aging and regulating testis size. Endocrinology, 154(3), 1310-20. https://doi.org/10.1210/en.2012-1886

FSTL3: A NOVEL REGULATOR OF GROWTH PLATE DYNAMICS?
Journal Article
Burleigh, A., Staines, K. A., Poulet, B., Pitsillides, A. A., & Mukherjee, A. FSTL3: A NOVEL REGULATOR OF GROWTH PLATE DYNAMICS?. International Journal of Experimental Pathology, 95(3), A6-A7

Biological Activity of Follistatin Isoforms and Follistatin like-3 are Dependent on Differential Cell Surface Binding and Specificity for Activin, Myostatin and BMP's
Journal Article
Sidis, Y., Mukherjee, A., Keutmann, H., Delbaere, A., Sadatsuki, M., & Schneyer, A. Biological Activity of Follistatin Isoforms and Follistatin like-3 are Dependent on Differential Cell Surface Binding and Specificity for Activin, Myostatin and BMP's. Endocrinology, 147(7), 3586-3597. https://doi.org/10.1210/en.2006-0089