All Outputs (53)

Seasonal and dietary influences on adipose tissue and systemic gene expression in control and previously laminitic ponies (2018)
Journal Article
Timpson, A., De Mestre, A. M., Elliott, J., Harris, P. A., Cheng, Z. R., Mirczuk, S. M., …Menzies-Gow, N. J. (2018). Seasonal and dietary influences on adipose tissue and systemic gene expression in control and previously laminitic ponies. Journal of Equine Veterinary Science, https://doi.org/10.1016/j.jevs.2018.06.009

The aims of the study were to determine whether adipose tissue global gene expression (i) differs between never laminitic (NL) and previously laminitic (PL) ponies; (ii) is influenced by season and/or a diet designed to simulate spring grass and (iii... Read More about Seasonal and dietary influences on adipose tissue and systemic gene expression in control and previously laminitic ponies.

Glial Cells Missing 1 Regulates Equine Chorionic Gonadotrophin Beta Subunit via Binding to the Proximal Promoter (2018)
Journal Article
Read, J. E., Cabrera-Sharp, V., Kitscha, P., Cartwright, J. E., King, P. J., Fowkes, R. C., & De Mestre, A. M. (2018). Glial Cells Missing 1 Regulates Equine Chorionic Gonadotrophin Beta Subunit via Binding to the Proximal Promoter. Frontiers in Endocrinology, 9, https://doi.org/10.3389/fendo.2018.00195

Equine chorionic gonadotrophin (eCG) is a placental glycoprotein critical for early equine pregnancy and used therapeutically in a number of species to support reproductive activity. The factors in trophoblast that transcriptionally regulate eCGβ-sub... Read More about Glial Cells Missing 1 Regulates Equine Chorionic Gonadotrophin Beta Subunit via Binding to the Proximal Promoter.

Descriptive study of current therapeutic practices, clinical reproductive findings and incidence of pregnancy loss in intensively managed thoroughbred mares (2017)
Journal Article
Rose, B. V., Firth, M. J., Morris, B., Roach, J. M., Wathes, D. C., Verheyen, K. L. P., & De Mestre, A. M. (2017). Descriptive study of current therapeutic practices, clinical reproductive findings and incidence of pregnancy loss in intensively managed thoroughbred mares. Animal Reproduction Science, 188, 74-84. https://doi.org/10.1016/j.anireprosci.2017.11.011

Therapeutic practices in equine reproductive medicine have dramatically evolved over the last 20 years but current usage is not described. The aims of this study were to provide a description of medication use and clinical findings of reproductive ex... Read More about Descriptive study of current therapeutic practices, clinical reproductive findings and incidence of pregnancy loss in intensively managed thoroughbred mares.

The effects of intrauterine infusion of peanut oil on endometrial health, salivary cortisol and interovulatory period in mares (2017)
Journal Article
Campbell, M. L. H., Hampshire, D., Hamstead, L., Rose, B., Smith, K. C., & De Mestre, A. M. (2017). The effects of intrauterine infusion of peanut oil on endometrial health, salivary cortisol and interovulatory period in mares. Theriogenology, 102, 116-125. https://doi.org/10.1016/j.theriogenology.2017.07.009

Intrauterine infusion of peanut oil at Day 10 post-ovulation has been reported to prolong dioestrus in mares. However, the effects of peanut oil treatment on the endometrium and whether the technique is painful have not been assessed. The objectives... Read More about The effects of intrauterine infusion of peanut oil on endometrial health, salivary cortisol and interovulatory period in mares.

Convergent evolution of pregnancy-specific glycoproteins in human and horse (2016)
Journal Article
Aleksic, D., Blaschke, L., Missbach, S., Hänske, J., Weiss, W., Handler, J., …Kammerer, R. (2016). Convergent evolution of pregnancy-specific glycoproteins in human and horse. Reproduction, 152, 171-184. https://doi.org/10.1530/REP-16-0236

Pregnancy-specific glycoproteins (PSGs) are members of the carcinoembryonic antigen cell adhesion molecule (CEACAM) family that are secreted by trophoblast cells. PSGs may modulate immune, angiogenic and platelet responses during pregnancy. Until now... Read More about Convergent evolution of pregnancy-specific glycoproteins in human and horse.

Regulatory T-cell-intrinsic amphiregulin is dispensable for suppressive function (2016)
Journal Article
Carney, K., Chang, Y. M., Wilson, S., Calnan, C., Reddy, P. S., Chan, W. Y., …Garden, O. A. (2016). Regulatory T-cell-intrinsic amphiregulin is dispensable for suppressive function. Journal of Allergy and Clinical Immunology, 137(6), 1907-9. https://doi.org/10.1016/j.jaci.2016.01.030

A method for isolating and culturing placental cells from failed early equine pregnancies (2016)
Journal Article
Rose, B. V., Cabrera-Sharp, V., Firth, M. J., Barrelet, F. E., Bate, S., Cameron, I. J., …De Mestre, A. M. (2016). A method for isolating and culturing placental cells from failed early equine pregnancies. Placenta, 38, 107-111. https://doi.org/10.1016/j.placenta.2015.12.014

Early pregnancy loss occurs in 6–10% of equine pregnancies making it the main cause of reproductive wastage. Despite this, reasons for the losses are known in only 16% of cases. Lack of viable conceptus material has inhibited investigations of many p... Read More about A method for isolating and culturing placental cells from failed early equine pregnancies.

SMAD1/5 signaling in the early equine placenta regulates trophoblast differentiation and chorionic gonadotropin secretion (2014)
Journal Article
Cabrera-Sharp, V., Read, J. E., Richardson, S., Kowalski, A. A., Antczak, D. F., Cartwright, J. E., …De Mestre, A. M. (2014). SMAD1/5 signaling in the early equine placenta regulates trophoblast differentiation and chorionic gonadotropin secretion. Endocrinology, 155(8), 3054-64. https://doi.org/10.1210/en.2013-2116

TGFβ superfamily proteins, acting via SMAD (Sma- and Mad-related protein)2/3 pathways, regulate placental function; however, the role of SMAD1/5/8 pathway in the placenta is unknown. This study investigated the functional role of bone morphogenetic p... Read More about SMAD1/5 signaling in the early equine placenta regulates trophoblast differentiation and chorionic gonadotropin secretion.

DIFFERENTIAL EXPRESSION OF THE TRANSCRIPTS ENCODING EPIDERMAL GROWTH FACTOR RECEPTOR AND ITS LIGANDS BY CD4(+) T HELPER SUBSETS IN RESPONSE TO T CELL RECEPTOR ENGAGEMENT
Journal Article
Carney, K., Chan, W. Y., Singh, Y., Cobb, B. S., De Mestre, A. M., Affleck, K., & Garden, O. A. DIFFERENTIAL EXPRESSION OF THE TRANSCRIPTS ENCODING EPIDERMAL GROWTH FACTOR RECEPTOR AND ITS LIGANDS BY CD4(+) T HELPER SUBSETS IN RESPONSE TO T CELL RECEPTOR ENGAGEMENT. Immunology, 140, 145-145

Glial Cells Missing Homologue 1 Is Induced in Differentiating Equine Chorionic Girdle Trophoblast Cells
Journal Article
De Mestre, A. M., Miller, D., Roberson, M. S., Liford, J., Chizmar, L. C., McLaughlin, K. E., & Antczak, D. F. Glial Cells Missing Homologue 1 Is Induced in Differentiating Equine Chorionic Girdle Trophoblast Cells. Biology of Reproduction, 80(2), 227-234. https://doi.org/10.1095/biolreprod.108.070920

The objective of this study was to identify transcription factors associated with differentiation of the chorionic girdle, the invasive form of equine trophoblast. The expression patterns of five transcription factors were determined on a panel of co... Read More about Glial Cells Missing Homologue 1 Is Induced in Differentiating Equine Chorionic Girdle Trophoblast Cells.

INVESTIGATION OF THE ROLE OF INTEGRIN ALPHA2 SUBUNIT IN EQUINE TROPHOBLAST ATTACHMENT AND INVASION
Journal Article
Sones, J. L., Miller, D., De Mestre, A. M., Decarlo, C., Harman, R., & Antczak, D. F. INVESTIGATION OF THE ROLE OF INTEGRIN ALPHA2 SUBUNIT IN EQUINE TROPHOBLAST ATTACHMENT AND INVASION. Biology of Reproduction, 455

MODULATION OF LYMPHOCYTE PROLIFERATION AND CYTOKINE EXPRESSION BY PLACENTAL TROPHOBLAST CELLS AIDS IN MATERNAL-FETAL TOLERANCE
Journal Article
Robbin, M. G., Lawrence, R. A., Wagner, B., Antczak, D. F., & De Mestre, A. M. MODULATION OF LYMPHOCYTE PROLIFERATION AND CYTOKINE EXPRESSION BY PLACENTAL TROPHOBLAST CELLS AIDS IN MATERNAL-FETAL TOLERANCE. Immunology, 131(1), 189-189

Split immunological tolerance to trophoblast
Journal Article
De Mestre, A. M., Noronha, L., Wagner, B., & Antczak, D. F. Split immunological tolerance to trophoblast. International Journal of Developmental Biology, 54(2-3), 445-455. https://doi.org/10.1387/ijdb.082795ad

Subpopulations of equine blood lymphocytes expressing regulatory T cell markers
Journal Article
Robbin, M. G., Wagner, B., Noronha, L. E., Antczak, D. F., & De Mestre, A. M. Subpopulations of equine blood lymphocytes expressing regulatory T cell markers. Veterinary Immunology and Immunopathology, 140(1-2), 90-101. https://doi.org/10.1016/j.vetimm.2010.11.020

Functions of ectopically transplanted invasive horse trophoblast
Conference Proceeding
De Mestre, A. M., Hanlon, D., Adams, A. P., Runcan, E., Leadbeater, J. C., Erb, N. H., …Antczak, D. F. Functions of ectopically transplanted invasive horse trophoblast. https://doi.org/10.1530/REP-10-0462

Molecular evidence for natural killer-like cells in equine endometrial cups
Journal Article
Noronha, L. E., Huggler, K. E., De Mestre, A. M., Miller, D. C., & Antczak, D. F. Molecular evidence for natural killer-like cells in equine endometrial cups. Placenta, 33(5), 379-386. https://doi.org/10.1016/j.placenta.2012.01.018

Clinical presentation, treatment and possible causes of persistent endometrial cups illustrated by two cases
Journal Article
Crabtree, J. R., Chang, Y. M., & De Mestre, A. M. Clinical presentation, treatment and possible causes of persistent endometrial cups illustrated by two cases. Equine Veterinary Education, 24(5), 251-259. https://doi.org/10.1111/j.2042-3292.2011.00354.x

REGULATION OF CHORIONIC GIRDLE TROPHOBLAST DIFFERENTIATION BY TGF beta SIGNALLING PATHWAYS
Journal Article
Cabrera-Sharp, V., Richardson, S., Miller, D., Antczak, D. F., Mukherjee, A., & De Mestre, A. M. REGULATION OF CHORIONIC GIRDLE TROPHOBLAST DIFFERENTIATION BY TGF beta SIGNALLING PATHWAYS. Placenta, 33(9), A36-A36

GCM1 ALTERS THE DIFFERENTIATION PATTERN OF EQUINE CHORIONIC GIRDLE TROPHOBLAST CELLS
Journal Article
Cabrera-Sharp, V., Martyn, A., Antczak, D. F., & De Mestre, A. M. GCM1 ALTERS THE DIFFERENTIATION PATTERN OF EQUINE CHORIONIC GIRDLE TROPHOBLAST CELLS. Placenta, 33(9), A33-A33

IFPA Meeting 2011 workshop report III: Placental immunology; epigenetic and microRNA-dependent gene regulation; comparative placentation; trophoblast differentiation; stem cells
Journal Article
Ackerman, W. E., Bulmer, J. N., Carter, A. M., Chaillet, J. R., Chamley, L., Chen, C. P., …Lash, G. E. IFPA Meeting 2011 workshop report III: Placental immunology; epigenetic and microRNA-dependent gene regulation; comparative placentation; trophoblast differentiation; stem cells. Placenta, 33, S15-S22. https://doi.org/10.1016/j.placenta.2011.11.022