All Outputs (167)

Occipital foramina development involves localised regulation of mesenchyme proliferation and is independent of apoptosis (2015)
Journal Article
Akbareian, S. E., Pitsillides, A. A., Macharia, R. G., & McGonnell, I. M. (2015). Occipital foramina development involves localised regulation of mesenchyme proliferation and is independent of apoptosis. Journal of Anatomy, 226(6), 560-574. https://doi.org/10.1111/joa.12304

Cranial foramina are holes within the skull, formed during development, allowing entry and exit of blood vessels and nerves. Once formed they must remain open, due to the vital structures they contain, i.e. optic nerves, jugular vein, carotid artery,... Read More about Occipital foramina development involves localised regulation of mesenchyme proliferation and is independent of apoptosis.

Local origins impart conserved bone type-related differences in human osteoblast behaviour (2015)
Journal Article
Shah, M., Gburcik, V., Reilly, P., Sankey, R. A., Emery, R. J., Clarkin, C. E., & Pitsillides, A. A. (2015). Local origins impart conserved bone type-related differences in human osteoblast behaviour. https://doi.org/10.22203/eCM.v029a12

Osteogenic behaviour of osteoblasts from trabecular, cortical and subchondral bone were examined to determine any bone type-selective differences in samples from both osteoarthritic (OA) and osteoporotic (OP) patients. Cell growth, differentiation; a... Read More about Local origins impart conserved bone type-related differences in human osteoblast behaviour.

Structure, ontogeny and evolution of the patellar tendon in emus (Dromaius novaehollandiae) and other palaeognath birds (2015)
Journal Article
Regnault, S., Pitsillides, A. A., & Hutchinson, J. R. (2015). Structure, ontogeny and evolution of the patellar tendon in emus (Dromaius novaehollandiae) and other palaeognath birds. https://doi.org/10.7717/peerj.711

The patella (kneecap) exhibits multiple evolutionary origins in birds, mammals, and lizards, and is thought to increase the mechanical advantage of the knee extensor muscles. Despite appreciable interest in the specialized anatomy and locomotion of p... Read More about Structure, ontogeny and evolution of the patellar tendon in emus (Dromaius novaehollandiae) and other palaeognath birds.

Vitamin K catabolite inhibition of ovariectomy-induced bone loss: Structure–activity relationship considerations (2014)
Journal Article
Soper, R. J., Oguz, C., Emery, R., Pitsillides, A. A., & Hodges, S. J. (2014). Vitamin K catabolite inhibition of ovariectomy-induced bone loss: Structure–activity relationship considerations. Molecular Nutrition & Food Research, 58(8), 1658-1666. https://doi.org/10.1002/mnfr.201400063

The potential benefit of vitamin K as a therapeutic in osteoporosis is controversial and the vitamin K regimen being used clinically (45 mg/day) employs doses that are many times higher than required to ensure maximal gamma‐carboxylation of the vitam... Read More about Vitamin K catabolite inhibition of ovariectomy-induced bone loss: Structure–activity relationship considerations.

Modifications of Gait as Predictors of Natural Osteoarthritis Progression in STR/Ort Mice (2014)
Journal Article
Poulet, B., De Souza, R., Knights, C. B., Gentry, C., Wilson, A. M., Bevan, S., Chang, Y. M., & Pitsillides, A. A. (2014). Modifications of Gait as Predictors of Natural Osteoarthritis Progression in STR/Ort Mice. https://doi.org/10.1002/art.38616

Cartilage to bone transitions in health and disease
Journal Article
Staines, K. A., Pollard, A. S., McGonnell, I. M., Farquharson, C., & Pitsillides, A. A. Cartilage to bone transitions in health and disease. Journal of Endocrinology, 219(1), R1-R12. https://doi.org/10.1530/joe-13-0276

From Flat Foot to Fat Foot: Structure, Ontogeny, Function, and Evolution of Elephant "Sixth Toes"
Journal Article
Hutchinson, J. R., Delmer, C., Miller, C. E., Hildebrandt, T., Pitsillides, A. A., & Boyde, A. From Flat Foot to Fat Foot: Structure, Ontogeny, Function, and Evolution of Elephant "Sixth Toes". Science, 334(6063), 1699-1703. https://doi.org/10.1126/science.1211437

THE SCLEROSTIN AND MEPE AXIS IN THE DEVELOPMENT OF OSTEOARTHRTTIS
Journal Article
Staines, K. A., Poulet, B., Farquharson, C., & Pitsillides, A. A. THE SCLEROSTIN AND MEPE AXIS IN THE DEVELOPMENT OF OSTEOARTHRTTIS

STABILISING CARTILAGE TO INNATELY PROTECT AGAINST OSTEOARTHRITIS: LESSONS FROM LONG BONE DEVELOPMENT
Presentation / Conference Contribution
Staines, K. A., Poulet, B., Farquharson, C., & Pitsillides, A. A. STABILISING CARTILAGE TO INNATELY PROTECT AGAINST OSTEOARTHRITIS: LESSONS FROM LONG BONE DEVELOPMENT

NEW BONE FOR OLD CARTILAGE; GROWTH PATTERNS OF THE BIZARRE 'SIXTH TOES' OF ELEPHANTS
Presentation / Conference Contribution
Boyde, A., Pitsillides, A. A., & Hutchinson, J. R. NEW BONE FOR OLD CARTILAGE; GROWTH PATTERNS OF THE BIZARRE 'SIXTH TOES' OF ELEPHANTS

Expression of endothelial nitric oxide synthase protein is not necessary for mechanical strain-induced nitric oxide production by cultured osteoblasts
Journal Article
Das-Gupta, V., Williamson, R. A., & Pitsillides, A. A. Expression of endothelial nitric oxide synthase protein is not necessary for mechanical strain-induced nitric oxide production by cultured osteoblasts. Osteoporosis International, 23(11), 2635-2647. https://doi.org/10.1007/s00198-012-1957-2

DOES THE VASODILATORY ACTION OF PTH HELP ACCOUNT FOR ITS OSTEOGENIC EFFECTS?
Journal Article
Marenzana, M., Chenu, C., Pitsillides, A. A., & Arnett, T. R. DOES THE VASODILATORY ACTION OF PTH HELP ACCOUNT FOR ITS OSTEOGENIC EFFECTS?

Cervical expression of hyaluronan synthases varies with the stage of the estrous cycle in the ewe
Journal Article
Perry, K. L., Haresign, W., Wathes, D. C., Pitsillides, A. A., & Khalid, M. Cervical expression of hyaluronan synthases varies with the stage of the estrous cycle in the ewe. Theriogenology, 77(6), 1100-1110. https://doi.org/10.1016/j.theriogenology.2011.10.012

Extracellular Matrix Mineralization Promotes E11/gp38 Glycoprotein Expression and Drives Osteocytic Differentiation
Journal Article
Prideaux, M., Loveridge, N., Pitsillides, A. A., & Farquharson, C. Extracellular Matrix Mineralization Promotes E11/gp38 Glycoprotein Expression and Drives Osteocytic Differentiation. PLoS ONE, 7(5), e36786. https://doi.org/10.1371/journal.pone.0036786

Regulation of UDP-Glucose Dehydrogenase Is Sufficient to Modulate Hyaluronan Production and Release, Control Sulfated GAG Synthesis, and Promote Chondrogenesis
Journal Article
Clarkin, C. E., Allen, S., Kuiper, N. J., Wheeler, B. T., Wheeler-Jones, C. P. D., & Pitsillides, A. A. Regulation of UDP-Glucose Dehydrogenase Is Sufficient to Modulate Hyaluronan Production and Release, Control Sulfated GAG Synthesis, and Promote Chondrogenesis. Journal of Cellular Physiology, 226(3), 749-761. https://doi.org/10.1002/jcp.22393

Reduced chondrogenic matrix accumulation by 4-methylumbelliferone reveals the potential for selective targeting of UDP-glucose dehydrogenase
Journal Article
Clarkin, C. E., Allen, S. P., Wheeler-Jones, C. P. D., Bastow, E. R., & Pitsillides, A. A. Reduced chondrogenic matrix accumulation by 4-methylumbelliferone reveals the potential for selective targeting of UDP-glucose dehydrogenase. Matrix Biology, 30(3), 163-168. https://doi.org/10.1016/j.matbio.2011.01.002

LIKE A HOLE IN THE HEAD; DEVELOPMENT OF CRANIAL FORAMINA IN THE CHICK EMBRYO
Presentation / Conference Contribution
Akbareian, S. E., Pitsillides, A. A., Fowkes, R. C., & McGonnell, I. M. LIKE A HOLE IN THE HEAD; DEVELOPMENT OF CRANIAL FORAMINA IN THE CHICK EMBRYO

Using Cell and Organ Culture Models to Analyze Responses of Bone Cells to Mechanical Stimulation
Book Chapter
Pitsillides, A. A., & Rawlinson, S. C. F. Using Cell and Organ Culture Models to Analyze Responses of Bone Cells to Mechanical Stimulation. . https://doi.org/10.1007/978-1-61779-415-5_37

GENE ARRAY PROFILING OF ARTICULAR CHONDROCYTES IN MICE WITH DIFFERENT SUSCEPTIBILITY TO NATURAL DISEASE REVEALS SPECIFIC GENE SIGNATURES LINKED TO HEALTHY AGEING AND SPONTANEOUS OA
Journal Article
Poulet, B., Veronica, U., Stone, T. C., Pead, M., Gburcik, V., Beier, F., Timmons, J. A., & Pitsillides, A. A. GENE ARRAY PROFILING OF ARTICULAR CHONDROCYTES IN MICE WITH DIFFERENT SUSCEPTIBILITY TO NATURAL DISEASE REVEALS SPECIFIC GENE SIGNATURES LINKED TO HEALTHY AGEING AND SPONTANEOUS OA

Time-series transcriptional profiling yields new perspectives on susceptibility to murine osteoarthritis
Journal Article
Poulet, B., Ulici, V., Stone, T. C., Pead, M. J., Gburcik, V., Constantinou, E., Palmer, D. B., Beier, F., Timmons, J. A., & Pitsillides, A. A. Time-series transcriptional profiling yields new perspectives on susceptibility to murine osteoarthritis. Arthritis and Rheumatism, 64(10), 3256-3266. https://doi.org/10.1002/art.34572