All Outputs (168)

Phospho1 deficiency transiently modifies bone architecture yet produces consistent modification in osteocyte differentiation and vascular porosity with ageing (2015)
Journal Article
Javaheri, B., Carriero, A., Staines, K. A., Chang, Y. M., Houston, D. A., Oldknow, K. J., Millan, J. L., Kazeruni, B. N., Salmon, P., Shefelbine, S., Farquharson, C., & Pitsillides, A. A. (2015). Phospho1 deficiency transiently modifies bone architecture yet produces consistent modification in osteocyte differentiation and vascular porosity with ageing. BONE, 81, 277-291. https://doi.org/10.1016/j.bone.2015.07.035

PHOSPHO1 is one of principal proteins involved in initiating bone matrix mineralisation. Recent studies have found that Phospho1 KO mice (Phospho1-R74X) display multiple skeletal abnormalities with spontaneous fractures, bowed long bones, osteomalaci... Read More about Phospho1 deficiency transiently modifies bone architecture yet produces consistent modification in osteocyte differentiation and vascular porosity with ageing.

Occipital foramina development involves localised regulation of mesenchyme proliferation and is independent of apoptosis (2015)
Journal Article
Akbareian, S. E., Pitsillides, A. A., Macharia, R. G., & McGonnell, I. M. (2015). Occipital foramina development involves localised regulation of mesenchyme proliferation and is independent of apoptosis. Journal of Anatomy, 226(6), 560-574. https://doi.org/10.1111/joa.12304

Cranial foramina are holes within the skull, formed during development, allowing entry and exit of blood vessels and nerves. Once formed they must remain open, due to the vital structures they contain, i.e. optic nerves, jugular vein, carotid artery,... Read More about Occipital foramina development involves localised regulation of mesenchyme proliferation and is independent of apoptosis.

Local origins impart conserved bone type-related differences in human osteoblast behaviour (2015)
Journal Article
Shah, M., Gburcik, V., Reilly, P., Sankey, R. A., Emery, R. J., Clarkin, C. E., & Pitsillides, A. A. (2015). Local origins impart conserved bone type-related differences in human osteoblast behaviour. https://doi.org/10.22203/eCM.v029a12

Osteogenic behaviour of osteoblasts from trabecular, cortical and subchondral bone were examined to determine any bone type-selective differences in samples from both osteoarthritic (OA) and osteoporotic (OP) patients. Cell growth, differentiation; a... Read More about Local origins impart conserved bone type-related differences in human osteoblast behaviour.

Structure, ontogeny and evolution of the patellar tendon in emus (Dromaius novaehollandiae) and other palaeognath birds (2015)
Journal Article
Regnault, S., Pitsillides, A. A., & Hutchinson, J. R. (2015). Structure, ontogeny and evolution of the patellar tendon in emus (Dromaius novaehollandiae) and other palaeognath birds. https://doi.org/10.7717/peerj.711

The patella (kneecap) exhibits multiple evolutionary origins in birds, mammals, and lizards, and is thought to increase the mechanical advantage of the knee extensor muscles. Despite appreciable interest in the specialized anatomy and locomotion of p... Read More about Structure, ontogeny and evolution of the patellar tendon in emus (Dromaius novaehollandiae) and other palaeognath birds.

Vitamin K catabolite inhibition of ovariectomy-induced bone loss: Structure–activity relationship considerations (2014)
Journal Article
Soper, R. J., Oguz, C., Emery, R., Pitsillides, A. A., & Hodges, S. J. (2014). Vitamin K catabolite inhibition of ovariectomy-induced bone loss: Structure–activity relationship considerations. Molecular Nutrition & Food Research, 58(8), 1658-1666. https://doi.org/10.1002/mnfr.201400063

The potential benefit of vitamin K as a therapeutic in osteoporosis is controversial and the vitamin K regimen being used clinically (45 mg/day) employs doses that are many times higher than required to ensure maximal gamma‐carboxylation of the vitam... Read More about Vitamin K catabolite inhibition of ovariectomy-induced bone loss: Structure–activity relationship considerations.

Modifications of Gait as Predictors of Natural Osteoarthritis Progression in STR/Ort Mice (2014)
Journal Article
Poulet, B., De Souza, R., Knights, C. B., Gentry, C., Wilson, A. M., Bevan, S., Chang, Y. M., & Pitsillides, A. A. (2014). Modifications of Gait as Predictors of Natural Osteoarthritis Progression in STR/Ort Mice. https://doi.org/10.1002/art.38616

Human osteoblasts' proliferative responses to strain and 17 beta-estradiol are mediated by the estrogen receptor and the receptor for insulin-like growth factor I
Journal Article
Cheng, M. Z., Rawlinson, S. C. F., Pitsillides, A. A., Zaman, G., Mohan, S., Baylink, D. J., & Lanyon, L. E. Human osteoblasts' proliferative responses to strain and 17 beta-estradiol are mediated by the estrogen receptor and the receptor for insulin-like growth factor I. Journal of Bone and Mineral Research, 17(4), 593-602. https://doi.org/10.1359/jbmr.2002.17.4.593

Age-related changes in the response of human articular cartilage to IL-1 alpha and transforming growth factor-beta (TGF-beta) - Chondrocytes exhibit a diminished sensitivity to TGF-beta
Journal Article
Hickery, M. S., Bayliss, M. T., Dudhia, J., Lewthwaite, J. C., Edwards, J. C. W., & Pitsillides, A. A. Age-related changes in the response of human articular cartilage to IL-1 alpha and transforming growth factor-beta (TGF-beta) - Chondrocytes exhibit a diminished sensitivity to TGF-beta. Journal of Biological Chemistry, 278(52), 53063-53071. https://doi.org/10.1074/jbc.M209632200

Identifying and characterizing the joint cavity-forming cell
Presentation / Conference Contribution
Pitsillides, A. A. Identifying and characterizing the joint cavity-forming cell

A specific mechanomodulatory role for p38 MAPK in embryonic joint articular surface cell MEK-ERK pathway regulation
Journal Article
Lewthwaite, J. C., Bastow, E. R., Lamb, K. J., Blenis, J., Wheeler-Jones, C. P. D., & Pitsillides, A. A. A specific mechanomodulatory role for p38 MAPK in embryonic joint articular surface cell MEK-ERK pathway regulation. Journal of Biological Chemistry, 281(16), 11011-11018. https://doi.org/10.1074/jbc.M510680200

Mechanical strain and fluid movement both activate extracellular regulated kinase (ERK) in osteoblast-like cells but via different signaling pathways
Journal Article
Jessop, H. L., Rawlinson, S. C. F., Pitsillides, A. A., & Lanyon, L. E. Mechanical strain and fluid movement both activate extracellular regulated kinase (ERK) in osteoblast-like cells but via different signaling pathways. BONE, 31(1), 186-194. https://doi.org/10.1016/S8756-3282%2802%2900797-4

Diverse range of fixed positional deformities and bone growth restraint provoked by flaccid paralysis in embryonic chicks
Journal Article
Lamb, K. J., Lewthwaite, J. C., Lin, J. P., Simon, D., Kavanagh, E., Wheeler-Jones, C. P. D., & Pitsillides, A. A. Diverse range of fixed positional deformities and bone growth restraint provoked by flaccid paralysis in embryonic chicks. International Journal of Experimental Pathology, 84(4), 191-199

Differential regulation of GDF-5 and FGF-2/4 by immobilisation in ovo exposes distinct roles in joint formation
Journal Article
Kavanagh, E., Church, V. L., Osborne, A. C., Lamb, K. J., Archer, C. W., Francis-West, P., & Pitsillides, A. A. Differential regulation of GDF-5 and FGF-2/4 by immobilisation in ovo exposes distinct roles in joint formation. Developmental Dynamics, 235(3), 826-834. https://doi.org/10.1002/dvdy.20679

Anti-Inflammatory actions of vitamin K
Book Chapter
Hodges, S., Pitsillides, A. A., Ytrebo, L. M., & Soper, R. Anti-Inflammatory actions of vitamin K. In Biochemistry, Genetics and Molecular Biology (153-168). Intech. https://doi.org/10.5772/61430

EMBRYO MOVEMENT DRIVES CELLULAR PROGRESSION THROUGH THE DEVELOPING GROWTH PLATE
Presentation / Conference Contribution
Pollard, A. S., McGonnell, I. M., & Pitsillides, A. A. EMBRYO MOVEMENT DRIVES CELLULAR PROGRESSION THROUGH THE DEVELOPING GROWTH PLATE. Presented at Joint Meeting of the Bone Research Society and Bone Matrix Research Society

Defining boundaries during joint cavity formation: going out on a limb
Journal Article
Lamb, K. J., Lewthwaite, J. C., Bastow, E. R., & Pitsillides, A. A. Defining boundaries during joint cavity formation: going out on a limb. International Journal of Experimental Pathology, 84(2), 55-67. https://doi.org/10.1046/j.1365-2613.2003.00338.x

Keratan sulfate epitopes exhibit a conserved distribution during joint development that remains undisclosed on the basis of glycosaminoglycan charge density
Journal Article
Kavanagh, E., Osborne, A. C., Ashhurst, D. E., & Pitsillides, A. A. Keratan sulfate epitopes exhibit a conserved distribution during joint development that remains undisclosed on the basis of glycosaminoglycan charge density

Hepatic guanylate cyclase activity is decreased in a model of cirrhosis: A quantitative cytochemistry study
Journal Article
Davies, N. A., Hodges, S. J., Pitsillides, A. A., Mookerjee, R. P., Jalan, R., & Mehdizadeh, S. Hepatic guanylate cyclase activity is decreased in a model of cirrhosis: A quantitative cytochemistry study. FEBS Letters, 580(8), 2123-2128. https://doi.org/10.1016/j.febslet.2006.02.080

CHARACTERISING THE SPOTTY OSTEOMALACIA IN PHOSPHO1 KNOCKOUT MICE
Presentation / Conference Contribution
Boyde, A., Staines, K. A., Javaheri, B., Millan, J. L., Pitsillides, A. A., & Farquharson, C. CHARACTERISING THE SPOTTY OSTEOMALACIA IN PHOSPHO1 KNOCKOUT MICE. Presented at Joint Meeting of the Bone Research Society and Bone Matrix Research Society

Patterns of osteocytic endothelial nitric oxide synthase expression in the femoral neck cortex: Differences between cases of intracapsular hip fracture and controls
Journal Article
Loveridge, N., Fletcher, S., Power, J., Caballero-Alias, A. M., Das-Gupta, V., Rushton, N., Parker, M., Reeve, J., & Pitsillides, A. A. Patterns of osteocytic endothelial nitric oxide synthase expression in the femoral neck cortex: Differences between cases of intracapsular hip fracture and controls. BONE, 30(6), 866-871. https://doi.org/10.1016/S8756-3282%2802%2900732-9