Reduced chondrogenic matrix accumulation by 4-methylumbelliferone reveals the potential for selective targeting of UDP-glucose dehydrogenase

Clarkin, C E; Allen, S P; Wheeler-Jones, C P D; Bastow, E R; Pitsillides, A A

doi:10.1016/j.matbio.2011.01.002

GAIT ASYMMETRY AND IMBALANCE AS POTENTIAL MARKERS OF NATURAL OSTEOARTHRITIS DEVELOPMENT IN MICE
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Piles, M., Poulet, B., de Souza, R., Pitsillides, A. A., & Chang, Y. M. GAIT ASYMMETRY AND IMBALANCE AS POTENTIAL MARKERS OF NATURAL OSTEOARTHRITIS DEVELOPMENT IN MICE

Mechanoadaptation of developing limbs: shaking a leg
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Pollard, A. S., McGonnell, I. M., & Pitsillides, A. A. Mechanoadaptation of developing limbs: shaking a leg. Journal of Anatomy, 224(6), 615-623. https://doi.org/10.1111/joa.12171

THE INDUCTION OF BOTH PROGRESSIVE AND NON-PROGRESSIVE ARTICULAR CARTILAGE LESION FOLLOWING TRAUMA IN C57BL/6 MICE
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Poulet, B., & Pitsillides, A. A. THE INDUCTION OF BOTH PROGRESSIVE AND NON-PROGRESSIVE ARTICULAR CARTILAGE LESION FOLLOWING TRAUMA IN C57BL/6 MICE. International Journal of Experimental Pathology, 95(3), A28-A29

Gait analysis in Str/ort mice reveals modified paw area as a predictor of natural osteoarthritis progression
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Poulet, B., Souza, R., Knight, C., Wilson, A. M., Bevan, S., Chang, Y. M., & Pitsillides, A. A. Gait analysis in Str/ort mice reveals modified paw area as a predictor of natural osteoarthritis progression. Arthritis and Rheumatism, 66(7), 1832-1842. https://doi.org/10.1002/art.38616

FIBRILLIN-1 EXPRESSION, WHICH REGULATES OF TGF-B BIOAVAILABILITY, IS MODIFIED DURING OSTEOARTHRITIS AND MUTATIONS LEAD TO OSTEOARTHRITIS
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Ramanayake, W., Jones, H., Orriss, I. R., Arnett, T., Pitsillides, A. A., Denton, C., Abraham, D., & Poulet, B. FIBRILLIN-1 EXPRESSION, WHICH REGULATES OF TGF-B BIOAVAILABILITY, IS MODIFIED DURING OSTEOARTHRITIS AND MUTATIONS LEAD TO OSTEOARTHRITIS

STR/ORT MICE EXHIBIT AN INHERENT ENDOCHONDRAL GROWTH DEFECT AND REDEPLOY TRANSIENT CHONDROCYTE BEHAVIOURS PRIOR TO OSTEOARTHRITIS ONSET
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Staines, K. A., Parker, S., Poulet, B., Mirczuk, S. M., Fowkes, R. C., Hopkinson, M., Madi, K., Lee, P. D., & Pitsillides, A. A. STR/ORT MICE EXHIBIT AN INHERENT ENDOCHONDRAL GROWTH DEFECT AND REDEPLOY TRANSIENT CHONDROCYTE BEHAVIOURS PRIOR TO OSTEOARTHRITIS ONSET

MITOPHAGY DYSFUNCTION LOCALISES TO REGIONS OF NATURAL OSTEOARTHRITIS IN STR/ORT MICE
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Staines, K. A., Wood, L., Mainenti, M., Hopkinson, M., Mirczuk, S. M., Fowkes, R. C., Campanella, M., & Pitsillides, A. A. MITOPHAGY DYSFUNCTION LOCALISES TO REGIONS OF NATURAL OSTEOARTHRITIS IN STR/ORT MICE

Follistatin-like 3 (FSTL3) mediated silencing of transforming growth factor ß (TGFß) signaling is essential for testicular aging and regulating testis size
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Oldknow, K. J., Seebacher, J., Goswami, T., Villen, J., Pitsillides, A. A., O'Shaughnessy, P. J., Gygi, S. P., Schneyer, A. L., & Mukherjee, A. Follistatin-like 3 (FSTL3) mediated silencing of transforming growth factor ß (TGFß) signaling is essential for testicular aging and regulating testis size. Endocrinology, 154(3), 1310-20. https://doi.org/10.1210/en.2012-1886

Spontaneous osteoarthritis in Str/ort mice is unlikely due to greater vulnerability to mechanical trauma
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Poulet, B., Westerhof, T. A. T., Hamilton, R. W., Shefelbine, S. J., & Pitsillides, A. A. Spontaneous osteoarthritis in Str/ort mice is unlikely due to greater vulnerability to mechanical trauma. Osteoarthritis and Cartilage, 21(5), 756-763. https://doi.org/10.1016/j.joca.2013.02.652

Susceptibility to spontaneous OA is not necessarily linked to a vulnerability of articular cartilage to mechanical trauma
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Poulet, B., Westerhof, T., Shefelbine, S., & Pitsillides, A. A. Susceptibility to spontaneous OA is not necessarily linked to a vulnerability of articular cartilage to mechanical trauma. Osteoarthritis and Cartilage,

THICKENING OF SUBCHONDRAL BONE IS REGIONALISED BY LOADING OF DAMAGED ARTICULAR CARTILAGE AND CONTRA-LATERAL CHANGES ARE LINKED TO GAIT MODIFICATION
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Poulet, B., de Souza, R., Kent, A. V., Saxon, L. K., Barker, O., Wilson, A. M., Chang, Y. M., Cake, M., & Pitsillides, A. A. THICKENING OF SUBCHONDRAL BONE IS REGIONALISED BY LOADING OF DAMAGED ARTICULAR CARTILAGE AND CONTRA-LATERAL CHANGES ARE LINKED TO GAIT MODIFICATION

Cartilage to bone transitions in health and disease
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Staines, K. A., Pollard, A. S., McGonnell, I. M., Farquharson, C., & Pitsillides, A. A. Cartilage to bone transitions in health and disease. Journal of Endocrinology, 219(1), R1-R12. https://doi.org/10.1530/joe-13-0276

THE SCLEROSTIN AND MEPE AXIS IN THE DEVELOPMENT OF OSTEOARTHRTTIS
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Staines, K. A., Poulet, B., Farquharson, C., & Pitsillides, A. A. THE SCLEROSTIN AND MEPE AXIS IN THE DEVELOPMENT OF OSTEOARTHRTTIS

Expression of endothelial nitric oxide synthase protein is not necessary for mechanical strain-induced nitric oxide production by cultured osteoblasts
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Das-Gupta, V., Williamson, R. A., & Pitsillides, A. A. Expression of endothelial nitric oxide synthase protein is not necessary for mechanical strain-induced nitric oxide production by cultured osteoblasts. Osteoporosis International, 23(11), 2635-2647. https://doi.org/10.1007/s00198-012-1957-2

DOES THE VASODILATORY ACTION OF PTH HELP ACCOUNT FOR ITS OSTEOGENIC EFFECTS?
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Marenzana, M., Chenu, C., Pitsillides, A. A., & Arnett, T. R. DOES THE VASODILATORY ACTION OF PTH HELP ACCOUNT FOR ITS OSTEOGENIC EFFECTS?

Cervical expression of hyaluronan synthases varies with the stage of the estrous cycle in the ewe
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Perry, K. L., Haresign, W., Wathes, D. C., Pitsillides, A. A., & Khalid, M. Cervical expression of hyaluronan synthases varies with the stage of the estrous cycle in the ewe. Theriogenology, 77(6), 1100-1110. https://doi.org/10.1016/j.theriogenology.2011.10.012

Time-series transcriptional profiling yields new perspectives on susceptibility to murine osteoarthritis
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Poulet, B., Ulici, V., Stone, T. C., Pead, M. J., Gburcik, V., Constantinou, E., Palmer, D. B., Beier, F., Timmons, J. A., & Pitsillides, A. A. Time-series transcriptional profiling yields new perspectives on susceptibility to murine osteoarthritis. Arthritis and Rheumatism, 64(10), 3256-3266. https://doi.org/10.1002/art.34572

GENE ARRAY PROFILING OF ARTICULAR CHONDROCYTES IN MICE WITH DIFFERENT SUSCEPTIBILITY TO NATURAL DISEASE REVEALS SPECIFIC GENE SIGNATURES LINKED TO HEALTHY AGEING AND SPONTANEOUS OA
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Poulet, B., Veronica, U., Stone, T. C., Pead, M., Gburcik, V., Beier, F., Timmons, J. A., & Pitsillides, A. A. GENE ARRAY PROFILING OF ARTICULAR CHONDROCYTES IN MICE WITH DIFFERENT SUSCEPTIBILITY TO NATURAL DISEASE REVEALS SPECIFIC GENE SIGNATURES LINKED TO HEALTHY AGEING AND SPONTANEOUS OA

Extracellular Matrix Mineralization Promotes E11/gp38 Glycoprotein Expression and Drives Osteocytic Differentiation
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Prideaux, M., Loveridge, N., Pitsillides, A. A., & Farquharson, C. Extracellular Matrix Mineralization Promotes E11/gp38 Glycoprotein Expression and Drives Osteocytic Differentiation. PLoS ONE, 7(5), e36786. https://doi.org/10.1371/journal.pone.0036786

Reduced chondrogenic matrix accumulation by 4-methylumbelliferone reveals the potential for selective targeting of UDP-glucose dehydrogenase
Journal Article
Clarkin, C. E., Allen, S. P., Wheeler-Jones, C. P. D., Bastow, E. R., & Pitsillides, A. A. Reduced chondrogenic matrix accumulation by 4-methylumbelliferone reveals the potential for selective targeting of UDP-glucose dehydrogenase. Matrix Biology, 30(3), 163-168. https://doi.org/10.1016/j.matbio.2011.01.002

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