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All Outputs (9)

Age and Sex Differences in Load-Induced Tibial Cortical Bone Surface Strain Maps (2021)
Journal Article
Carriero, A., Javaheri, B., Kazeruni, N., Pitsillides, A., & Shefelbine, S. (2021). Age and Sex Differences in Load-Induced Tibial Cortical Bone Surface Strain Maps. JBMR Plus, 5(3), https://doi.org/10.1002/jbm4.10467

Bone adapts its architecture to the applied load; however, it is still unclear how bone mechano-adaptation is coordinated and why potential for adaptation adjusts during the life course. Previous animal models have suggested strain as the mechanical... Read More about Age and Sex Differences in Load-Induced Tibial Cortical Bone Surface Strain Maps.

Multiscale molecular profiling of pathological bone resolves sexually dimorphic control of extracellular matrix composition (2021)
Journal Article
Sharma, A., Goring, A., Johnson, P., Emery, R., Hesse, E., Boyde, A., Olsen, B., Pitsillides, A., Oreffo, R., Mahajan, S., & Clarkin, C. (2021). Multiscale molecular profiling of pathological bone resolves sexually dimorphic control of extracellular matrix composition. Disease Models and Mechanisms, 14(3), https://doi.org/10.1242/dmm.048116

Collagen assembly during development is essential for successful matrix mineralisation, which determines bone quality and mechanocompetence. However, the biochemical and structural perturbations that drive pathological skeletal collagen configuration... Read More about Multiscale molecular profiling of pathological bone resolves sexually dimorphic control of extracellular matrix composition.

An examination of two different approaches for the study of femoral neck fracture: towards a more relevant rodent model (2021)
Journal Article
Monzem, S., Gohin, S., Yagüe Ballester, R., Lopes de Souza, R., Meeson, R., & Anthony Pitsillides, A. (2021). An examination of two different approaches for the study of femoral neck fracture: towards a more relevant rodent model. Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine, https://doi.org/10.1177/09544119211053057

Femoral neck fractures are a massive personal and health programme burden. Methods to study femoral neck strength, across its combined trabecular and cortical components are therefore essential. Rodent ovariectomy-induced osteoporosis models are comm... Read More about An examination of two different approaches for the study of femoral neck fracture: towards a more relevant rodent model.

CD146 Delineates an Interfascicular Cell Sub-Population in Tendon That Is Recruited during Injury through Its Ligand Laminin-α4 (2021)
Journal Article
Marr, N., Meeson, R., Kelly, E., Fang, Y., Peffers, M., Pitsillides, A., Dudhia, J., & Thorpe, C. (2021). CD146 Delineates an Interfascicular Cell Sub-Population in Tendon That Is Recruited during Injury through Its Ligand Laminin-α4. International Journal of Molecular Sciences, https://doi.org/10.3390/ijms22189729

The interfascicular matrix (IFM) binds tendon fascicles and contains a population of morphologically distinct cells; however the role of IFM-localised cell populations in tendon repair remains to be determined. The basement membrane protein laminin-α... Read More about CD146 Delineates an Interfascicular Cell Sub-Population in Tendon That Is Recruited during Injury through Its Ligand Laminin-α4.

Sciatic neurectomy-related cortical bone loss exhibits delayed onset yet stabilises more rapidly than trabecular bone (2021)
Journal Article
Monzem, S., Javaheri, B., de Souza, R. L., & Pitsillides, A. A. (2021). Sciatic neurectomy-related cortical bone loss exhibits delayed onset yet stabilises more rapidly than trabecular bone. Bone Reports, 101116. https://doi.org/10.1016/j.bonr.2021.101116

Disuse osteoporosis occurs after extended periods of bed rest or nerve damage leading to increased risk of fracture. It remains to be established, however, whether the trajectory of bone loss is equivalent in bone's cortical and trabecular compartmen... Read More about Sciatic neurectomy-related cortical bone loss exhibits delayed onset yet stabilises more rapidly than trabecular bone.

A new straightforward method for semi-automated segmentation of trabecular bone from cortical bone in diverse and challenging morphologies (2021)
Journal Article
Pitsillides, A., Herbst, E., Felder, A., Evans, L., Anjami, S., & Javaheri, B. (2021). A new straightforward method for semi-automated segmentation of trabecular bone from cortical bone in diverse and challenging morphologies. Royal Society Open Science, https://doi.org/10.1098/rsos.210408

Many physiological, biomechanical, evolutionary and clinical studies that explore skeletal structure and function require successful separation of trabecular from cortical compartments of a bone that has been imaged by X-ray micro-computed tomography... Read More about A new straightforward method for semi-automated segmentation of trabecular bone from cortical bone in diverse and challenging morphologies.

Systematic analysis reveals that colony housing aligns gait profiles and strengthens link between 1 histological and micro-CT bone markers in rat models of osteoarthritis 2 Short running title: Colony housing strengthens osteoarthritis research (2021)
Journal Article
Chang, Y.-M., Menges, S., Westhof, A., Kleinschmidt-Doerr, K., Brenneis, C., Pitsillides, A. A., & Chang, Y.-M. (in press). Systematic analysis reveals that colony housing aligns gait profiles and strengthens link between 1 histological and micro-CT bone markers in rat models of osteoarthritis 2 Short running title: Colony housing strengthens osteoarthritis research. FASEB Journal, -. https://doi.org/10.1096/fj.202002009R