All Outputs (2)

Porcupine inhibition is a promising pharmacological treatment for severe sclerosteosis pathologies (2025)
Journal Article
Dreyer, T., Keen, J., Wells, L., Hopkinson, M., Orriss, I., Holdsworth, G., Pitsillides, A., & Roberts, S. (2025). Porcupine inhibition is a promising pharmacological treatment for severe sclerosteosis pathologies. Bone Research, 13(1), https://doi.org/10.1038/s41413-025-00406-3

Sclerosteosis, an ultra-rare disorder characterised by high bone mass (HBM) and skeletal overgrowth, leads to facial paralysis, hearing loss and raised intracranial pressure, which is currently managed only through high-risk surgery. Sclerosteosis is... Read More about Porcupine inhibition is a promising pharmacological treatment for severe sclerosteosis pathologies.

Extracellular matrix: Dystroglycan interactions-Roles for the dystrophin-associated glycoprotein complex in skeletal tissue dynamics (2025)
Journal Article
Hopkinson, M., & Pitsillides, A. (2025). Extracellular matrix: Dystroglycan interactions-Roles for the dystrophin-associated glycoprotein complex in skeletal tissue dynamics. International Journal of Experimental Pathology, 106(2), https://doi.org/10.1111/iep.12525

Contributions made by the dystrophin-associated glycoprotein complex (DGC) to cell-cell and cell-extracellular matrix (ECM) interactions are vital in development, homeostasis and pathobiology. This review explores how DGC functions may extend to skel... Read More about Extracellular matrix: Dystroglycan interactions-Roles for the dystrophin-associated glycoprotein complex in skeletal tissue dynamics.