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Dog leucocyte antigen (DLA) class II haplotypes and risk of canine diabetes mellitus in specific dog breeds (2020)
Journal Article
Denyer, A. L., Massey, J. P., Davison, L. J., Ollier, W. E. R., Catchpole, B., & Kennedy, L. J. (2020). Dog leucocyte antigen (DLA) class II haplotypes and risk of canine diabetes mellitus in specific dog breeds. Canine Medicine and Genetics, 7(1), 15. https://doi.org/10.1186/s40575-020-00093-9

Abstract: Background: Canine diabetes mellitus (DM) is a common endocrine disease in domestic dogs. A number of pathological mechanisms are thought to contribute to the aetiopathogenesis of relative or absolute insulin deficiency, including immune-me... Read More about Dog leucocyte antigen (DLA) class II haplotypes and risk of canine diabetes mellitus in specific dog breeds.

Polymorphisms in the CTLA4 promoter sequence are associated with canine hypoadrenocorticism (2020)
Journal Article
Boag, A. M., Short, A., Kennedy, L. J., Syme, H., Graham, P. A., & Catchpole, B. (2020). Polymorphisms in the CTLA4 promoter sequence are associated with canine hypoadrenocorticism. Canine Medicine and Genetics, 7(2), https://doi.org/10.1186/s40575-020-0081-4

Canine hypoadrenocorticism is an immune-mediated endocrinopathy that shares both clinical and pathophysiological similarities with Addison’s disease in humans. Several dog breeds are overrepresented in the disease population, suggesting that a geneti... Read More about Polymorphisms in the CTLA4 promoter sequence are associated with canine hypoadrenocorticism.

An investigation of polymorphisms in innate and adaptive immune response genes in canine leishmaniosis (2019)
Journal Article
Soutter, F., Solano-Gallego, L., Attipa, C., Gradoni, L., Fiorentino, E., Foglia Manzillo, V., …Catchpole, B. (2019). An investigation of polymorphisms in innate and adaptive immune response genes in canine leishmaniosis. Veterinary Parasitology, 269, 34-41. https://doi.org/10.1016/j.vetpar.2019.04.011

The outcome of infection with Leishmania infantum in dogs is variable, which is thought to be due to the nature of the immune response mounted by the host. As a consequence, the clinical signs and severity of canine leishmaniosis vary between individ... Read More about An investigation of polymorphisms in innate and adaptive immune response genes in canine leishmaniosis.

A longitudinal study of autoantibodies against cytochrome P450 side-chain cleavage enzyme in dogs (Canis lupus familiaris) affected with hypoadrenocorticism (Addison’s disease) (2018)
Journal Article
Boag, A. M., Christie, M. R., McLaughlin, K. A., Syme, H. M., Graham, P., & Catchpole, B. (2018). A longitudinal study of autoantibodies against cytochrome P450 side-chain cleavage enzyme in dogs (Canis lupus familiaris) affected with hypoadrenocorticism (Addison’s disease). Veterinary Immunology and Immunopathology, 202, 41-45. https://doi.org/10.1016/j.vetimm.2018.05.013

Autoantibodies directed against the P450 side chain cleavage enzyme (P450scc) have been recently described in dogs affected with hypoadrenocorticism, consistent with an immune-mediated pathogenesis of this endocrinopathy. In human autoimmune Addison’... Read More about A longitudinal study of autoantibodies against cytochrome P450 side-chain cleavage enzyme in dogs (Canis lupus familiaris) affected with hypoadrenocorticism (Addison’s disease).

Inconsistent MHC class II association in Beagles experimentally infected with Leishmania infantum (2018)
Journal Article
Soutter, F., Martorell, S., Solano-Gallego, L., & Catchpole, B. (2018). Inconsistent MHC class II association in Beagles experimentally infected with Leishmania infantum. https://doi.org/10.1016/j.tvjl.2018.03.001

The clinical outcome of Leishmania infantum infection in dogs varies from subclinical infection to severe disease. Researchers attribute this variability in clinical manifestations to the ability of the immune response to limit pathogen multiplicatio... Read More about Inconsistent MHC class II association in Beagles experimentally infected with Leishmania infantum.

Polymorphisms in the canine IL7R 3 ' UTR are associated with thymic output in Labrador retriever dogs and influence post-transcriptional regulation by microRNA 185 (2018)
Journal Article
Holder, A. L., Jones, G., Soutter, F., Palmer, D. B., Aspinall, R., & Catchpole, B. (2018). Polymorphisms in the canine IL7R 3 ' UTR are associated with thymic output in Labrador retriever dogs and influence post-transcriptional regulation by microRNA 185. Developmental and Comparative Immunology, 81, 244-251. https://doi.org/10.1016/j.dci.2017.12.008

Interleukin-7 (IL-7) and its receptor (IL-7R) are essential for T cell development in the thymus, and changes in the IL-7/IL-7R pathway have been implicated in age-associated thymic involution which results in a reduction of naïve T cell output. The... Read More about Polymorphisms in the canine IL7R 3 ' UTR are associated with thymic output in Labrador retriever dogs and influence post-transcriptional regulation by microRNA 185.

Feline hypersomatotropism and acromegaly tumorigenesis: a potential role for the AIP gene (2017)
Journal Article
Scudder, C. J., Niessen, S. J. M., Catchpole, B., Fowkes, R. C., Church, D. B., & Forcada, Y. (2017). Feline hypersomatotropism and acromegaly tumorigenesis: a potential role for the AIP gene. Domestic Animal Endocrinology, 59, 134-139. https://doi.org/10.1016/j.domaniend.2016.11.005

Acromegaly in humans is usually sporadic, however up to 20% of familial isolated pituitary adenomas are caused by germline sequence variants of the aryl-hydrocarbon-receptor interacting protein (AIP) gene. Feline acromegaly has similarities to human... Read More about Feline hypersomatotropism and acromegaly tumorigenesis: a potential role for the AIP gene.

An Age-Associated Decline in Thymic Output Differs in Dog Breeds According to Their Longevity (2016)
Journal Article
Holder, A., Mella, S., Palmer, D. B., Aspinall, R., & Catchpole, B. (2016). An Age-Associated Decline in Thymic Output Differs in Dog Breeds According to Their Longevity. PLoS ONE, 11, e0165968. https://doi.org/10.1371/journal.pone.0165968

The age associated decline in immune function is preceded in mammals by a reduction in thymic output. Furthermore, there is increasing evidence of a link between immune competence and lifespan. One approach to determining thymic output is to quantify... Read More about An Age-Associated Decline in Thymic Output Differs in Dog Breeds According to Their Longevity.

Single Nucleotide Polymorphisms in Major histocompatibility class II haplotypes are associated with potential resistance to inflammatory bowel disease in German shepherd dogs (2016)
Journal Article
Peiravan, A., Allenspach, K., Boag, A. M., Soutter, F., Holder, A. L., Catchpole, B., …Procoli, F. (2016). Single Nucleotide Polymorphisms in Major histocompatibility class II haplotypes are associated with potential resistance to inflammatory bowel disease in German shepherd dogs. Veterinary Immunology and Immunopathology, 182, 101-105. https://doi.org/10.1016/j.vetimm.2016.10.012

Breed differences in development of anti-insulin antibodies in diabetic dogs and investigation of the role of dog leukocyte antigen (DLA) genes (2015)
Journal Article
Holder, A. L., Kennedy, L. J., Ollier, W. E. R., & Catchpole, B. (2015). Breed differences in development of anti-insulin antibodies in diabetic dogs and investigation of the role of dog leukocyte antigen (DLA) genes. Veterinary Immunology and Immunopathology, 167(3-4), 130-8. https://doi.org/10.1016/j.vetimm.2015.07.014

Administration of insulin for treatment of diabetes mellitus in dogs can stimulate an immune response, with a proportion of animals developing anti-insulin antibodies (AIA). For an IgG antibody response to occur, this would require B cell presentatio... Read More about Breed differences in development of anti-insulin antibodies in diabetic dogs and investigation of the role of dog leukocyte antigen (DLA) genes.

Recombinant canine single chain insulin analogues: Insulin receptor binding capacity and ability to stimulate glucose uptake (2014)
Journal Article
Adams, J. P., Holder, A. L., & Catchpole, B. (2014). Recombinant canine single chain insulin analogues: Insulin receptor binding capacity and ability to stimulate glucose uptake. https://doi.org/10.1016/j.tvjl.2014.09.027

Virtually all diabetic dogs require exogenous insulin therapy to control their hyperglycaemia. In the UK, the only licensed insulin product currently available is a purified porcine insulin preparation. Recombinant insulin is somewhat problematic in... Read More about Recombinant canine single chain insulin analogues: Insulin receptor binding capacity and ability to stimulate glucose uptake.

A retrospective study of the prevalence of the canine degenerative myelopathy associated superoxide dismutase 1 mutation (SOD1: c. 118G> A) in a referral population of German Shepherd dogs from the UK (2014)
Journal Article
Holder, A. L., Price, J. A., Adams, J. P., Volk, H. A., & Catchpole, B. (2014). A retrospective study of the prevalence of the canine degenerative myelopathy associated superoxide dismutase 1 mutation (SOD1: c. 118G> A) in a referral population of German Shepherd dogs from the UK. Canine Genetics and Epidemiology, 1(10), https://doi.org/10.1186/2052-6687-1-10

Association between nucleotide oligomerisation domain two(Nod2) gene polymorphisms and canine inflammatory bowel disease (2014)
Journal Article
Kathrani, A., Lee, H., White, C., Catchpole, B., Murphy, A. M., German, A., …Allenspach, K. (2014). Association between nucleotide oligomerisation domain two(Nod2) gene polymorphisms and canine inflammatory bowel disease. Veterinary Immunology and Immunopathology, 161(1-2), 32-41. https://doi.org/10.1016/j.vetimm.2014.06.003

The most important genetic associations that have been implicated to play a role in the etiology of Crohn's disease (CD) in humans are single nucleotide polymorphisms (SNPs) in nucleotide oligomerisation domain 2 (NOD2). The aim of this study was to... Read More about Association between nucleotide oligomerisation domain two(Nod2) gene polymorphisms and canine inflammatory bowel disease.