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Polymorphisms in the CTLA4 promoter sequence are associated with canine hypoadrenocorticism

Boag, A M; Short, A; Kennedy, L J; Syme, H; Graham, P A; Catchpole, B

Authors

A M Boag

A Short

L J Kennedy

H Syme

P A Graham

B Catchpole



Abstract

Canine hypoadrenocorticism is an immune-mediated endocrinopathy that shares both clinical and pathophysiological similarities with Addison’s disease in humans. Several dog breeds are overrepresented in the disease population, suggesting that a genetic component is involved, although this is likely to be polygenic. Previous research has implicated CTLA4 as a potential susceptibility gene. CTLA4 is an important regulator of T cell function and polymorphisms/mutations in CTLA4 have been associated with a number of autoimmune phenotypes in both humans and rodent models of autoimmunity. The aim of the current study was to undertake a case:control association study of CTLA4 promotor polymorphisms in three dog breeds, cocker spaniels, springer spaniels and West Highland white terriers (WHWT).

Citation

Boag, A. M., Short, A., Kennedy, L. J., Syme, H., Graham, P. A., & Catchpole, B. (2020). Polymorphisms in the CTLA4 promoter sequence are associated with canine hypoadrenocorticism. Canine Medicine and Genetics, 7(2), https://doi.org/10.1186/s40575-020-0081-4

Journal Article Type Article
Acceptance Date Feb 18, 2020
Publication Date Mar 4, 2020
Deposit Date Mar 11, 2020
Publicly Available Date Mar 11, 2020
Journal Canine Medicine and Genetics
Print ISSN 2662-9380
Publisher BioMed Central
Peer Reviewed Peer Reviewed
Volume 7
Issue 2
DOI https://doi.org/10.1186/s40575-020-0081-4
Public URL https://rvc-repository.worktribe.com/output/1378348

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