Polymorphisms in the CTLA4 promoter sequence are associated with canine hypoadrenocorticism

Boag, A M; Short, A; Kennedy, L J; Syme, H; Graham, P A; Catchpole, B

Abstract

Canine hypoadrenocorticism is an immune-mediated endocrinopathy that shares both clinical and pathophysiological similarities with Addison’s disease in humans. Several dog breeds are overrepresented in the disease population, suggesting that a genetic component is involved, although this is likely to be polygenic. Previous research has implicated CTLA4 as a potential susceptibility gene. CTLA4 is an important regulator of T cell function and polymorphisms/mutations in CTLA4 have been associated with a number of autoimmune phenotypes in both humans and rodent models of autoimmunity. The aim of the current study was to undertake a case:control association study of CTLA4 promotor polymorphisms in three dog breeds, cocker spaniels, springer spaniels and West Highland white terriers (WHWT).

Citation

Boag, A. M., Short, A., Kennedy, L. J., Syme, H., Graham, P. A., & Catchpole, B. (2020). Polymorphisms in the CTLA4 promoter sequence are associated with canine hypoadrenocorticism. Canine Medicine and Genetics, 7(2), https://doi.org/10.1186/s40575-020-0081-4

• Journal Article Type: Article
• Acceptance Date: Feb 18, 2020
• Publication Date: Mar 4, 2020
• Deposit Date: Mar 11, 2020
• Publicly Available Date: Mar 11, 2020
• Journal: Canine Medicine and Genetics
• Print ISSN: 2662-9380
• Publisher: BioMed Central
• Peer Reviewed: Peer Reviewed
• Volume: 7
• Issue: 2
• DOI: https://doi.org/10.1186/s40575-020-0081-4
• Public URL: https://rvc-repository.worktribe.com/output/1378348