The ATPase Inhibitory Factor 1 (IF1) regulates the expression of the mitochondrial Ca2+ uniporter (MCU) via the AMPK/CREB pathway
(2020)
Journal Article
Faccenda, D., Gorini, G., Jones, A., Thornton, C., Baracca, A., Solaini, G., & Campanella, M. (2020). The ATPase Inhibitory Factor 1 (IF1) regulates the expression of the mitochondrial Ca2+ uniporter (MCU) via the AMPK/CREB pathway
•IF1 regulates MCU-dependent mitochondrial Ca2+ uptake. •IF1 loss induces MCU upregulation through activation of the AMPK/CREB pathway. •OMA1 depletion restores physiological MCU levels and mitochondrial Ca2+ entry.