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Neuroprotective Effects of Diabetes Drugs for the Treatment of Neonatal Hypoxia-Ischemia Encephalopathy

Poupon-Bejuit, L; Rocha-Ferreira, E; Thornton, C; Hagberg, H; Rahim, A A


L Poupon-Bejuit

E Rocha-Ferreira

C Thornton

H Hagberg

A A Rahim


The perinatal period represents a time of great vulnerability for the developing brain. A variety of injuries can result in death or devastating injury causing profound neurocognitive deficits. Hypoxic-ischemic neonatal encephalopathy (HIE) remains the leading cause of brain injury in term infants during the perinatal period with limited options available to aid in recovery. It can result in long-term devastating consequences with neurologic complications varying from mild behavioral deficits to severe seizure, intellectual disability, and/or cerebral palsy in the newborn. Despite medical advances, the only viable option is therapeutic hypothermia which is classified as the gold standard but is not used, or may not be as effective in preterm cases, infection-associated cases or low resource settings. Therefore, alternatives or adjunct therapies are urgently needed. Ongoing research continues to advance our understanding of the mechanisms contributing to perinatal brain injury and identify new targets and treatments. Drugs used for the treatment of patients with type 2 diabetes mellitus (T2DM) have demonstrated neuroprotective properties and therapeutic efficacy from neurological sequelae following HIE insults in preclinical models, both alone, or in combination with induced hypothermia. In this short review, we have focused on recent findings on the use of diabetes drugs that provide a neuroprotective effect using in vitro and in vivo models of HIE that could be considered for clinical translation as a promising treatment.


Poupon-Bejuit, L., Rocha-Ferreira, E., Thornton, C., Hagberg, H., & Rahim, A. A. (2020). Neuroprotective Effects of Diabetes Drugs for the Treatment of Neonatal Hypoxia-Ischemia Encephalopathy. Frontiers in Cellular Neuroscience, 14,

Journal Article Type Review
Acceptance Date Apr 8, 2020
Publication Date May 6, 2020
Deposit Date May 21, 2020
Publicly Available Date May 21, 2020
Journal Frontiers in Cellular Neuroscience
Publisher Frontiers Media
Peer Reviewed Peer Reviewed
Volume 14
Public URL


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