Preclinical development and characterisation of PP353, a formulation of linezolid for intradiscal administration
(2024)
Journal Article
Hagger, G., Guest, S., Birchall, S., Bradley, A., Brindley, C., Corbett, D., Cummings, P., Freire, C., Harris, J., Wise, A., Wood, M., & Czaplewski, L. (2024). Preclinical development and characterisation of PP353, a formulation of linezolid for intradiscal administration. JOR Spine, 7(4), https://doi.org/10.1002/jsp2.70010
IntroductionBacterial infection of the intervertebral disc can lead to vertebral endplate edema known as Modic changes, with associated chronic low back pain. Oral antimicrobial therapy has shown efficacy but relies on prolonged dosing and may not be... Read More about Preclinical development and characterisation of PP353, a formulation of linezolid for intradiscal administration.