All Outputs (3)

Transcriptomic analysis reveals a critical role for activating Gsα mutations in spontaneous feline hyperthyroidism (2024)
Journal Article
Hiron, T. K., Aguiar, J., Williams, J. M., Falcone, S., Norman, P. A., Elliott, J., Fowkes, R. C., Syme, H. M., & Davison, L. J. (in press). Transcriptomic analysis reveals a critical role for activating Gsα mutations in spontaneous feline hyperthyroidism. Scientific Reports, 14(1), https://doi.org/10.1038/s41598-024-79564-z

Somatic GNAQ, CTNNB1, and CACNA1C Mutations in Cat Aldosterone-Secreting Tumors (2024)
Journal Article
Watson, A., Syme, H., & Brown, M. (2024). Somatic GNAQ, CTNNB1, and CACNA1C Mutations in Cat Aldosterone-Secreting Tumors. Hypertension, 81(12), 2489-2500. https://doi.org/10.1161/HYPERTENSIONAHA.124.23501

BACKGROUND:Primary aldosteronism (PA) is a common cause of human hypertension. Somatic mutations in KCNJ5, CACNA1D, ATP1A1, and ATP2B3 are found in at least 80% of aldosterone-producing adenomas, which cause unilateral PA in humans. Somatic mutations... Read More about Somatic GNAQ, CTNNB1, and CACNA1C Mutations in Cat Aldosterone-Secreting Tumors.

Immunohistochemical expression of CYP11A1, CYP11B, CYP17, and HSD3B2 in functional and nonfunctional canine adrenocortical tumors (2024)
Journal Article
Allan, F., Watson, A., & Syme, H. (2024). Immunohistochemical expression of CYP11A1, CYP11B, CYP17, and HSD3B2 in functional and nonfunctional canine adrenocortical tumors. Journal of Veterinary Internal Medicine, https://doi.org/10.1111/jvim.17212

Background: Functionality of human adrenal tumors is inferred by CYP11B1 (cortisol synthase) expression, CYP11B2 (aldosterone synthase) expression, or both. Hypothesis/Objectives: Nonfunctional canine adrenal tumors have low expression of steroidogen... Read More about Immunohistochemical expression of CYP11A1, CYP11B, CYP17, and HSD3B2 in functional and nonfunctional canine adrenocortical tumors.