All Outputs (2)

STAT1-induced ASPP2 transcription identifies a link between neuroinflammation, cell polarity, and tumor suppression (2014)
Journal Article
Turnquist, C., Wang, Y., Severson, D. T., Zhong, S., Sun, B., Ma, J., Constaninescu, S. N., Ansorge, O., Stolp, H. B., Molnár, Z., Szele, F. G., & Lu, X. (2014). STAT1-induced ASPP2 transcription identifies a link between neuroinflammation, cell polarity, and tumor suppression. https://doi.org/10.1073/pnas.1407898111

Inflammation and loss of cell polarity play pivotal roles in neurodegeneration and cancer. A central question in both diseases is how the loss of cell polarity is sensed by cell death machinery. Here, we identify apoptosis-stimulating protein of p53... Read More about STAT1-induced ASPP2 transcription identifies a link between neuroinflammation, cell polarity, and tumor suppression.

CNS-targeted glucocorticoid reduces pathology in mouse model of amyotrophic lateral sclerosis (2014)
Journal Article
Evans, M. C., Gaillard, P. J., De Boer, M., Appeldoorn, C., Dorland, R., Sibson, N. R., Turner, M. R., Anthony, D. C., & Stolp, H. B. (2014). CNS-targeted glucocorticoid reduces pathology in mouse model of amyotrophic lateral sclerosis. Acta Neuropathologica Communications, 2, 66. https://doi.org/10.1186/2051-5960-2-66

Hallmarks of CNS inflammation, including microglial and astrocyte activation, are prominent features in post-mortem tissue from amyotrophic lateral sclerosis (ALS) patients and in mice overexpressing mutant superoxide dismutase-1 (SOD1 G93A ). Admini... Read More about CNS-targeted glucocorticoid reduces pathology in mouse model of amyotrophic lateral sclerosis.