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Whole genome resequencing of the human parasite Schistosoma mansoni reveals population history and effects of selection (2016)
Journal Article
Crellen, T., Allan, F., David, S., Durrant, C., Huckvale, T., Holroyd, N., …Cotton, J. A. (2016). Whole genome resequencing of the human parasite Schistosoma mansoni reveals population history and effects of selection. https://doi.org/10.1038/srep20954

Schistosoma mansoni is a parasitic fluke that infects millions of people in the developing world. This study presents the first application of population genomics to S. mansoni based on high-coverage resequencing data from 10 global isolates and an i... Read More about Whole genome resequencing of the human parasite Schistosoma mansoni reveals population history and effects of selection.

One Health – an Ecological and Evolutionary Framework for tackling Neglected Zoonotic Diseases (2016)
Journal Article
Webster, J. P., Gower, C. M., Knowles, S. C. L., & Fenton, A. (2016). One Health – an Ecological and Evolutionary Framework for tackling Neglected Zoonotic Diseases. Evolutionary Applications, 9(2), 313-333. https://doi.org/10.1111/eva.12341

Understanding the complex population biology and transmission ecology of multihost parasites has been declared as one of the major challenges of biomedical sciences for the 21st century and the Neglected Zoonotic Diseases (NZDs) are perhaps the most... Read More about One Health – an Ecological and Evolutionary Framework for tackling Neglected Zoonotic Diseases.

Multi-parallel qPCR provides increased sensitivity and diagnostic breadth for gastrointestinal parasites of humans: field-based inferences on the impact of mass deworming (2016)
Journal Article
Easton, A. V., Oliveira, R. G., O'Connell, E. M., Kepha, S., Mwandawiro, C. S., Njenga, S. M., …Nutman, T. B. (2016). Multi-parallel qPCR provides increased sensitivity and diagnostic breadth for gastrointestinal parasites of humans: field-based inferences on the impact of mass deworming. https://doi.org/10.1186/s13071-016-1314-y

Estimation of changes in the force of infection for intestinal and urogenital schistosomiasis in countries with Schistosomiasis Control Initiative-assisted programmes (2015)
Journal Article
French, M. D., Churcher, T. S., Webster, J. P., Fleming, F. M., Fenwick, A., Kabetereine, N. B., …Basáñez, M. (2015). Estimation of changes in the force of infection for intestinal and urogenital schistosomiasis in countries with Schistosomiasis Control Initiative-assisted programmes. https://doi.org/10.1186/s13071-015-1138-1

The last decade has seen an expansion of national schistosomiasis control programmes in Africa based on large-scale preventative chemotherapy. In many areas this has resulted in considerable reductions in infection and morbidity levels in treated ind... Read More about Estimation of changes in the force of infection for intestinal and urogenital schistosomiasis in countries with Schistosomiasis Control Initiative-assisted programmes.

Sensitivity and Specificity of Multiple Kato-Katz Thick Smears and a Circulating Cathodic Antigen Test for Schistosoma mansoni Diagnosis Pre- and Post-repeated-Praziquantel Treatment (2014)
Journal Article
Lamberton, P. H. L., Kabatereine, N. B., Oguttu, D. W., Fenwick, A., & Webster, J. P. (2014). Sensitivity and Specificity of Multiple Kato-Katz Thick Smears and a Circulating Cathodic Antigen Test for Schistosoma mansoni Diagnosis Pre- and Post-repeated-Praziquantel Treatment. PLoS Neglected Tropical Diseases, 8(9), https://doi.org/10.1371/journal.pntd.0003139

Two Kato-Katz thick smears (Kato-Katzs) from a single stool are currently recommended for diagnosing Schistosoma mansoni infections to map areas for intervention. This ‘gold standard’ has low sensitivity at low infection intensities. The urine point-... Read More about Sensitivity and Specificity of Multiple Kato-Katz Thick Smears and a Circulating Cathodic Antigen Test for Schistosoma mansoni Diagnosis Pre- and Post-repeated-Praziquantel Treatment.

Population genetic structure of Schistosoma mansoni and Schistosoma haematobium from across six sub-Saharan African countries: Implications for epidemiology, evolution and control
Journal Article
Gower, C. M., Gouvras, A. N., Lamberton, P. H. L., Deol, A., Shrivastava, J., Mutombo, P. N., …Webster, J. P. Population genetic structure of Schistosoma mansoni and Schistosoma haematobium from across six sub-Saharan African countries: Implications for epidemiology, evolution and control. Acta Tropica, 128(2), 261-274. https://doi.org/10.1016/j.actatropica.2012.09.014

Epidemiological interactions between urogenital and intestinal human schistosomiasis in the context of praziquantel treatment across three West African countries
Journal Article
Knowles, S. C. L., Webster, B. L., Garba, A., Sacko, M., Diaw, O. T., Fenwick, A., …Webster, J. P. (in press). Epidemiological interactions between urogenital and intestinal human schistosomiasis in the context of praziquantel treatment across three West African countries. PLoS Neglected Tropical Diseases, 9(10), https://doi.org/10.1371/journal.pntd.0004019

DNA 'barcoding' of Schistosoma mansoni across sub-Saharan Africa supports substantial within locality diversity and geographical separation of genotypes
Journal Article
Webster, B. L., Webster, J. P., Gouvras, A. N., Garba, A., Lamine, M. S., Diaw, O. T., …Stothard, J. R. DNA 'barcoding' of Schistosoma mansoni across sub-Saharan Africa supports substantial within locality diversity and geographical separation of genotypes. Acta Tropica, 128(2), 250-260. https://doi.org/10.1016/j.actatropica.2012.08.009

Integrated monitoring and evaluation and environmental risk factors for urogenital schistosomiasis and active trachoma in Burkina Faso before preventative chemotherapy using sentinel sites
Journal Article
Koukounari, A., Toure, S., Donnelly, C. A., Ouedraogo, A., Yoda, B., Ky, C., …Webster, J. P. Integrated monitoring and evaluation and environmental risk factors for urogenital schistosomiasis and active trachoma in Burkina Faso before preventative chemotherapy using sentinel sites. BMC Infectious Diseases, 11, https://doi.org/10.1186/1471-2334-11-191

Oxamniquine resistance alleles are widespread in Old World Schistosoma mansoni and predate drug deployment
Journal Article
Chevalier, F. D., Le Clec’h, W., McDew-White, M., Menon, V., Guzman, M. A., Holloway, S. P., …Anderson, T. J. C. (in press). Oxamniquine resistance alleles are widespread in Old World Schistosoma mansoni and predate drug deployment. PLoS Pathogens, 15(10), https://doi.org/10.1371/journal.ppat.1007881

Do mutations required for adaptation occur de novo, or are they segregating within populations as standing genetic variation? This question is key to understanding adaptive change in nature, and has important practical consequences for the evolution... Read More about Oxamniquine resistance alleles are widespread in Old World Schistosoma mansoni and predate drug deployment.

DEVELOPMENT OF NOVEL MULTIPLEX MICROSATELLITE POLYMERASE CHAIN REACTIONS TO ENABLE HIGH-THROUGHPUT POPULATION GENETIC STUDIES OF SCHISTOSOMA HAEMATOBIUM (VOL 8, 432, 2015)
Journal Article
Webster, B. L., Rabone, M., Pennance, T., Emery, A. M., Allan, F., Gouvras, A., …Webster, J. P. DEVELOPMENT OF NOVEL MULTIPLEX MICROSATELLITE POLYMERASE CHAIN REACTIONS TO ENABLE HIGH-THROUGHPUT POPULATION GENETIC STUDIES OF SCHISTOSOMA HAEMATOBIUM (VOL 8, 432, 2015). https://doi.org/10.1186/s13071-015-1134-5