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Sensitivity and Specificity of Multiple Kato-Katz Thick Smears and a Circulating Cathodic Antigen Test for Schistosoma mansoni Diagnosis Pre- and Post-repeated-Praziquantel Treatment

Lamberton, P H L; Kabatereine, N B; Oguttu, D W; Fenwick, A; Webster, J P

Authors

P H L Lamberton

N B Kabatereine

D W Oguttu

A Fenwick

J P Webster



Abstract

Two Kato-Katz thick smears (Kato-Katzs) from a single stool are currently recommended for diagnosing Schistosoma mansoni infections to map areas for intervention. This ‘gold standard’ has low sensitivity at low infection intensities. The urine point-of-care circulating cathodic antigen test (POC-CCA) is potentially more sensitive but how accurately they detect S. mansoni after repeated praziquantel treatments, their suitability for measuring drug efficacy and their correlation with egg counts remain to be fully understood. We compared the accuracies of one to six Kato-Katzs and one POC-CCA for the diagnosis of S. mansoni in primary-school children who have received zero to ten praziquantel treatments. We determined the impact each diagnostic approach may have on monitoring and evaluation (M&E) and drug-efficacy findings.

Citation

Lamberton, P. H. L., Kabatereine, N. B., Oguttu, D. W., Fenwick, A., & Webster, J. P. (2014). Sensitivity and Specificity of Multiple Kato-Katz Thick Smears and a Circulating Cathodic Antigen Test for Schistosoma mansoni Diagnosis Pre- and Post-repeated-Praziquantel Treatment. PLoS Neglected Tropical Diseases, 8(9), https://doi.org/10.1371/journal.pntd.0003139

Journal Article Type Article
Acceptance Date Jul 22, 2014
Publication Date Sep 11, 2014
Deposit Date Nov 12, 2014
Publicly Available Date Mar 28, 2024
Journal PLOS NEGLECTED TROPICAL DISEASES
Print ISSN 1935-2727
Publisher Public Library of Science
Peer Reviewed Peer Reviewed
Volume 8
Issue 9
DOI https://doi.org/10.1371/journal.pntd.0003139
Public URL https://rvc-repository.worktribe.com/output/1404900

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