Sensitivity and Specificity of Multiple Kato-Katz Thick Smears and a Circulating Cathodic Antigen Test for Schistosoma mansoni Diagnosis Pre- and Post-repeated-Praziquantel Treatment

Lamberton, P H L; Kabatereine, N B; Oguttu, D W; Fenwick, A; Webster, J P

Abstract

Two Kato-Katz thick smears (Kato-Katzs) from a single stool are currently recommended for diagnosing Schistosoma mansoni infections to map areas for intervention. This ‘gold standard’ has low sensitivity at low infection intensities. The urine point-of-care circulating cathodic antigen test (POC-CCA) is potentially more sensitive but how accurately they detect S. mansoni after repeated praziquantel treatments, their suitability for measuring drug efficacy and their correlation with egg counts remain to be fully understood. We compared the accuracies of one to six Kato-Katzs and one POC-CCA for the diagnosis of S. mansoni in primary-school children who have received zero to ten praziquantel treatments. We determined the impact each diagnostic approach may have on monitoring and evaluation (M&E) and drug-efficacy findings.

Citation

Lamberton, P. H. L., Kabatereine, N. B., Oguttu, D. W., Fenwick, A., & Webster, J. P. (2014). Sensitivity and Specificity of Multiple Kato-Katz Thick Smears and a Circulating Cathodic Antigen Test for Schistosoma mansoni Diagnosis Pre- and Post-repeated-Praziquantel Treatment. PLoS Neglected Tropical Diseases, 8(9), https://doi.org/10.1371/journal.pntd.0003139

• Journal Article Type: Article
• Acceptance Date: Jul 22, 2014
• Publication Date: Sep 11, 2014
• Deposit Date: Nov 12, 2014
• Publicly Available Date: Sep 3, 2018
• Journal: PLOS NEGLECTED TROPICAL DISEASES
• Print ISSN: 1935-2727
• Electronic ISSN: 1935-2735
• Publisher: Public Library of Science
• Peer Reviewed: Peer Reviewed
• Volume: 8
• Issue: 9
• DOI: https://doi.org/10.1371/journal.pntd.0003139
• Public URL: https://rvc-repository.worktribe.com/output/1404900