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In vivo efficiency of praziquantel treatment of single-sex Schistosoma three months old in mice

Wang, N; Peng, HQ; Gao, CZ; Cheng, YH; Sun, MT; Qu, GL; Webster, JP; Lu, DB


N Wang

HQ Peng

CZ Gao

YH Cheng

MT Sun


JP Webster



Schistosomiasis is a major neglected tropical disease mainly caused by Schistosoma haematobium, S. japonicum and S. mansoni, and results in the greatest disease burden. Mass drug administration (MDA) with praziquantel (PZQ), a single drug only available for the disease, has played a vital role in schistosomiasis control. Therefore, any possibility of selection of the parasites for PZQ resistance or low sensitivity may hamper the 2030's target of global disease elimination. We had experimentally demonstrated the long-term survival and reproductive potential of single-sex (of either sex) S. japonicum infections in definitive hosts mice. What has not yet been adequately addressed is whether the long live single-sex schistosomes remain sensitive to PZQ, and what reproduction potential for those schistosomes surviving treatment may have. We therefore performed experimental mice studies to explore the treatment effectiveness of PZQ (at total doses of 200 or 400 mg/kg, corresponding to the sub-standard or standard treatment doses in humans) for single-sex S. japonicum aged three months old. The results showed that no treatment efficiency was observed on female schistosomes, whereas on male schistosomes only at PZQ 400 mg/kg a significant higher efficiency in reducing worm burdens was observed. Moreover, either schistosome males or females surviving PZQ treatment remained their reproduction potential as normal. The results indicate that long (i.e., three months) live single-sex S. japonicum can easily survive the current treatment strategy, and moreover, any schistosomes, if with PZQ resistance or low sensitivity, could be easily transmitted in nature. Therefore, in order to realize the target for the national and the global schistosomiasis elimination, there is undoubtedly a great need for refining PZQ administration and dosage, looking for alternative therapies, and/or developing vaccines against schistosome.


Wang, N., Peng, H., Gao, C., Cheng, Y., Sun, M., Qu, G., …Lu, D. (2022). In vivo efficiency of praziquantel treatment of single-sex Schistosoma three months old in mice. International Journal for Parasitology: Drugs and Drug Resistance, 20, 129-134.

Journal Article Type Article
Acceptance Date Nov 8, 2022
Online Publication Date Nov 12, 2022
Publication Date 2022
Deposit Date Aug 16, 2023
Publicly Available Date Aug 16, 2023
Print ISSN 2211-3207
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 20
Pages 129-134
Keywords S; japonicum; Single -sex infection; Praziquantel; Treatment efficiency; JAPONICUM; MANSONI; RESISTANCE; CHINA; ANHUI


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