Oxamniquine resistance alleles are widespread in Old World Schistosoma mansoni and predate drug deployment

Chevalier, F D; Le Clec’h, W; McDew-White, M; Menon, V; Guzman, M A; Holloway, S P; Cao, X; Taylor, A B; Kinung'Hi, S; Gouvras, A N; Webster, B L; Webster, J P; Emery, A M; Rollinson, D; Garba Djirmay, A; Al Mashikhi, K M; Al Yafae, S; Idris, M A; Moné, H; Mouahid, G; Hart, P J; LoVerde, P T; Anderson, T J C

doi:10.1371/journal.ppat.1007881

The role of parasites and pathogens in influencing generalised anxiety and predation-related fear in the mammalian central nervous system
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Kaushik, M., Lamberton, P. H. L., & Webster, J. P. The role of parasites and pathogens in influencing generalised anxiety and predation-related fear in the mammalian central nervous system. https://doi.org/10.1016/j.yhbeh.2012.04.002

Genetic Diversity within Schistosoma haematobium: DNA Barcoding Reveals Two Distinct Groups
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Webster, B. L., Emery, A. M., Webster, J. P., Gouvras, A., Garba, A., Diaw, O., Seye, M. M., Tchuente, L. A. T., Simoonga, C., Mwanga, J., Lange, C. N., Kariuki, C., Mohammed, K. A., Stothard, J. R., & Rollinson, D. (in press). Genetic Diversity within Schistosoma haematobium: DNA Barcoding Reveals Two Distinct Groups. PLoS Neglected Tropical Diseases, 6(10), https://doi.org/10.1371/journal.pntd.0001882

Toxoplasma gondii infection, from predation to schizophrenia: can animal behaviour help us understand human behaviour?
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Webster, J. P., Kaushik, M., Bristow, G. C., & McConkey, G. A. Toxoplasma gondii infection, from predation to schizophrenia: can animal behaviour help us understand human behaviour?. Journal of Experimental Biology, 216(1), 99-112. https://doi.org/10.1242/jeb.074716

DNA 'barcoding' of Schistosoma mansoni across sub-Saharan Africa supports substantial within locality diversity and geographical separation of genotypes
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Webster, B. L., Webster, J. P., Gouvras, A. N., Garba, A., Lamine, M. S., Diaw, O. T., Seye, M. M., Tchuente, L. A. T., Simoonga, C., Mubila, L., Mwanga, J. R., Lwambo, N. J. S., Kabatereine, N. B., Lange, C. N., Kariuki, C., Mkoji, G. M., Rollinson, D., & Stothard, J. R. DNA 'barcoding' of Schistosoma mansoni across sub-Saharan Africa supports substantial within locality diversity and geographical separation of genotypes. Acta Tropica, 128(2), 250-260. https://doi.org/10.1016/j.actatropica.2012.08.009

Introgressive Hybridization of Schistosoma haematobium Group Species in Senegal: Species Barrier Break Down between Ruminant and Human Schistosomes
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Webster, B. L., Diaw, O. T., Seye, M. M., Webster, J. P., & Rollinson, D. Introgressive Hybridization of Schistosoma haematobium Group Species in Senegal: Species Barrier Break Down between Ruminant and Human Schistosomes. PLoS Neglected Tropical Diseases, 7(4), https://doi.org/10.1371/journal.pntd.0002110

Identifying host species driving transmission of schistosomiasis japonica, a multihost parasite system, in China
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Rudge, J. W., Webster, J. P., Lu, D. B., Wang, T. P., Fang, G. R., & Basáñez, M.-G. Identifying host species driving transmission of schistosomiasis japonica, a multihost parasite system, in China. https://doi.org/10.1073/pnas.1221509110

Life in cells, hosts, and vectors: Parasite evolution across scales
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Mideo, N., Acosta-Serrano, A., Aebischer, T., Brown, M. J. F., Fenton, A., Friman, V. P., Restif, O., Reece, S. E., Webster, J. P., & Brown, S. P. Life in cells, hosts, and vectors: Parasite evolution across scales. https://doi.org/10.1016/j.meegid.2012.03.016

Genetic diversity of Schistosoma japonicum miracidia from individual rodent hosts
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Lu, D. B., Wang, T. P., Rudge, J. W., Donnelly, C. A., Fang, G. R., & Webster, J. P. Genetic diversity of Schistosoma japonicum miracidia from individual rodent hosts. International Journal for Parasitology, 41(13-14), 1371-1376. https://doi.org/10.1016/j.ijpara.2011.09.002

The Neurotropic Parasite Toxoplasma Gondii Increases Dopamine Metabolism
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Prandovszky, E., Gaskell, E., Martin, H., Dubey, J. P., Webster, J. P., & McConkey, G. A. The Neurotropic Parasite Toxoplasma Gondii Increases Dopamine Metabolism. PLoS ONE, 6(9), https://doi.org/10.1371/journal.pone.0023866

Observed Reductions in Schistosoma mansoni Transmission from Large-Scale Administration of Praziquantel in Uganda: A Mathematical Modelling Study
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French, M. D., Churcher, T. S., Gambhir, M., Fenwick, A., Webster, J. P., Kabatereine, N. B., & Basáñez, M.-G. Observed Reductions in Schistosoma mansoni Transmission from Large-Scale Administration of Praziquantel in Uganda: A Mathematical Modelling Study. PLoS Neglected Tropical Diseases, 4(11), https://doi.org/10.1371/journal.pntd.0000897

Schistosomiasis in infants and preschool-aged children: Infection in a single Schistosoma haematobium and a mixed S. haematobium-S. mansoni foci of Niger
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Garba, A., Barkire, N., Djibo, A., Lamine, M. S., Sofo, B., Gouvras, A. N., Bosque-Oliva, E., Webster, J. P., Stothard, J. R., Utzinger, J., & Fenwick, A. Schistosomiasis in infants and preschool-aged children: Infection in a single Schistosoma haematobium and a mixed S. haematobium-S. mansoni foci of Niger. Acta Tropica, 115(3), 212-219. https://doi.org/10.1016/j.actatropica.2010.03.005

In Vitro Praziquantel Test Capable of Detecting Reduced In Vivo Efficacy in Schistosoma mansoni Human Infections
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Lamberton, P. H. L., Hogan, S. C., Kabatereine, N. B., Fenwick, A., & Webster, J. P. In Vitro Praziquantel Test Capable of Detecting Reduced In Vivo Efficacy in Schistosoma mansoni Human Infections. American Journal of Tropical Medicine and Hygiene, 83(6), 1340-1347. https://doi.org/10.4269/ajtmh.2010.10-0413

Microsatellite loci in the carcinogenic liver fluke, Opisthorchis viverrini and their application as population genetic markers
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Laoprom, N., Sithithaworn, P., Ando, K., Sithithaworn, J., Wongkham, S., Laha, T., Klinbunga, S., Webster, J. P., & Andrews, R. H. Microsatellite loci in the carcinogenic liver fluke, Opisthorchis viverrini and their application as population genetic markers. https://doi.org/10.1016/j.meegid.2009.11.005

Transmission of Schistosoma japonicum in Marshland and Hilly Regions of China: Parasite Population Genetic and Sibship Structure
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Lu, D. B., Rudge, J. W., Wang, T. P., Donnelly, C. A., Fang, G. R., & Webster, J. P. Transmission of Schistosoma japonicum in Marshland and Hilly Regions of China: Parasite Population Genetic and Sibship Structure. https://doi.org/10.1371/journal.pntd.0000781

Contrasting reservoirs for Schistosoma japonicum between marshland and hilly regions in Anhui, China - a two-year longitudinal parasitological survey
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Lu, D. B., Wang, T. P., Rudge, J. W., Donnelly, C. A., Fang, G. R., & Webster, J. P. Contrasting reservoirs for Schistosoma japonicum between marshland and hilly regions in Anhui, China - a two-year longitudinal parasitological survey. Parasitology, 137(1), 99-110. https://doi.org/10.1017/s003118200999103x

Genetic Consequences of Mass Human Chemotherapy for Schistosoma mansoni: Population Structure Pre- and Post-Praziquantel Treatment in Tanzania
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Norton, A. J., Gower, C. M., Lamberton, P. H. L., Webster, B. L., Lwambo, N. J. S., Blair, L., Fenwick, A., & Webster, J. P. Genetic Consequences of Mass Human Chemotherapy for Schistosoma mansoni: Population Structure Pre- and Post-Praziquantel Treatment in Tanzania. American Journal of Tropical Medicine and Hygiene, 83(4), 951-957. https://doi.org/10.4269/ajtmh.2010.10-0283

Toxoplasma gondii-altered host behaviour: clues as to mechanism of action
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Webster, J. P., & McConkey, G. A. Toxoplasma gondii-altered host behaviour: clues as to mechanism of action

Schistosome genomes: a wealth of information
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Webster, J. P., Oliviera, G., Rollinson, D., & Gower, C. M. Schistosome genomes: a wealth of information. Trends in Parasitology, 26(3), 103-106. https://doi.org/10.1016/j.pt.2009.12.006

DEVELOPMENT OF NOVEL MULTIPLEX MICROSATELLITE POLYMERASE CHAIN REACTIONS TO ENABLE HIGH-THROUGHPUT POPULATION GENETIC STUDIES OF SCHISTOSOMA HAEMATOBIUM (VOL 8, 432, 2015)
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Webster, B. L., Rabone, M., Pennance, T., Emery, A. M., Allan, F., Gouvras, A., Knopp, S., Garba, A., Hamidou, A. A., Mohammed, K. A., Ame, S. M., Rollinson, D., & Webster, J. P. DEVELOPMENT OF NOVEL MULTIPLEX MICROSATELLITE POLYMERASE CHAIN REACTIONS TO ENABLE HIGH-THROUGHPUT POPULATION GENETIC STUDIES OF SCHISTOSOMA HAEMATOBIUM (VOL 8, 432, 2015). https://doi.org/10.1186/s13071-015-1134-5

Oxamniquine resistance alleles are widespread in Old World Schistosoma mansoni and predate drug deployment
Journal Article
Chevalier, F. D., Le Clec’h, W., McDew-White, M., Menon, V., Guzman, M. A., Holloway, S. P., Cao, X., Taylor, A. B., Kinung'Hi, S., Gouvras, A. N., Webster, B. L., Webster, J. P., Emery, A. M., Rollinson, D., Garba Djirmay, A., Al Mashikhi, K. M., Al Yafae, S., Idris, M. A., Moné, H., Mouahid, G., …Anderson, T. J. C. (in press). Oxamniquine resistance alleles are widespread in Old World Schistosoma mansoni and predate drug deployment. PLoS Pathogens, 15(10), https://doi.org/10.1371/journal.ppat.1007881

Do mutations required for adaptation occur de novo, or are they segregating within populations as standing genetic variation? This question is key to understanding adaptive change in nature, and has important practical consequences for the evolution... Read More about Oxamniquine resistance alleles are widespread in Old World Schistosoma mansoni and predate drug deployment.

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