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All Outputs (274)

Randomized placebo-controlled clinical trial of a new chewable formulation of amlodipine for the treatment of hypertension in client-owned cats (2015)
Journal Article
Huhtinen, M., Derre, G., Renoldi, H. J., Rinkinen, M., Adler, K., Aspegren, J., …Elliott, J. (2015). Randomized placebo-controlled clinical trial of a new chewable formulation of amlodipine for the treatment of hypertension in client-owned cats. Journal of Veterinary Internal Medicine, 29(3), 786-793. https://doi.org/10.1111/jvim.12589

Feline Chronic Kidney Disease Is Associated with Upregulation of Transglutaminase 2: A Collagen Cross-Linking Enzyme (2015)
Journal Article
Sanchez-Lara, A. C., Elliott, J., Syme, H. M., Brown, C. A., & Haylor, J. L. (2015). Feline Chronic Kidney Disease Is Associated with Upregulation of Transglutaminase 2: A Collagen Cross-Linking Enzyme. Veterinary Pathology, 52(3), 513-523. https://doi.org/10.1177/0300985814542811

Chronic kidney disease is a major cause of morbidity and mortality in cats. Transglutaminase 2 (TG2) is a calcium-dependent enzyme proposed to mediate tubulointerstitial fibrosis in the kidney by cross-linking collagen fibrils. Postmortem kidney tiss... Read More about Feline Chronic Kidney Disease Is Associated with Upregulation of Transglutaminase 2: A Collagen Cross-Linking Enzyme.

Renal fibrosis in feline chronic kidney disease: known mediators and mechanisms of injury (2015)
Journal Article
Lawson, J. S., Elliott, J., Wheeler-Jones, C. P. D., Syme, H. M., & Jepson, R. E. (2015). Renal fibrosis in feline chronic kidney disease: known mediators and mechanisms of injury. https://doi.org/10.1016/j.tvjl.2014.10.009

Chronic kidney disease (CKD) is a common medical condition of ageing cats. In most cases the underlying aetiology is unknown, but the most frequently reported pathological diagnosis is renal tubulointerstitial fibrosis. Renal fibrosis, characterised... Read More about Renal fibrosis in feline chronic kidney disease: known mediators and mechanisms of injury.

Cardiovascular effects of dietary salt intake in aged healthy cats: a 2-year prospective randomized, blinded, and controlled study (2014)
Journal Article
Chetboul, V., Reynolds, B. S., Trehiou-Sechi, E., Nguyen, P., Concordet, D., Sampedrano, C. C., …Lefebvre, H. P. (2014). Cardiovascular effects of dietary salt intake in aged healthy cats: a 2-year prospective randomized, blinded, and controlled study. PLoS ONE, 9(6), e97862. https://doi.org/10.1371/journal.pone.0097862

High salt dry expanded diets are commercially available for cats to increase water intake and urine volume, as part of the prevention or treatment of naturally occurring urinary stone formation (calcium oxalates and struvites). However, chronic high... Read More about Cardiovascular effects of dietary salt intake in aged healthy cats: a 2-year prospective randomized, blinded, and controlled study.

Assessment of low-dose cisplatin as a model of nausea and emesis in beagle dogs, potential for repeated administration (2014)
Journal Article
Kenward, H., Pelligand, L., & Elliott, J. (2014). Assessment of low-dose cisplatin as a model of nausea and emesis in beagle dogs, potential for repeated administration. Experimental Brain Research, 232(8), 2685-2697. https://doi.org/10.1007/s00221-014-3961-6

Cisplatin is a highly emetogenic cancer chemotherapy agent, which is often used to induce nausea and emesis in animal models. The cytotoxic properties of cisplatin also cause adverse events that negatively impact on animal welfare preventing repeated... Read More about Assessment of low-dose cisplatin as a model of nausea and emesis in beagle dogs, potential for repeated administration.

Differential pharmacokinetics and pharmacokinetic/pharmacodynamic modelling of robenacoxib and ketoprofen in a feline model of inflammation (2014)
Journal Article
Pelligand, L., King, J. N., Hormazabal, V., Toutain, P. L., Elliott, J., & Lees, P. (2014). Differential pharmacokinetics and pharmacokinetic/pharmacodynamic modelling of robenacoxib and ketoprofen in a feline model of inflammation. Journal of Veterinary Pharmacology and Therapeutics, 37(4), 354-366. https://doi.org/10.1111/jvp.12107

Robenacoxib and ketoprofen are acidic nonsteroidal anti‐inflammatory drugs (NSAIDs). Both are licensed for once daily administration in the cat, despite having short blood half‐lives. This study reports the pharmacokinetic/pharmacodynamic (PK/PD) mod... Read More about Differential pharmacokinetics and pharmacokinetic/pharmacodynamic modelling of robenacoxib and ketoprofen in a feline model of inflammation.