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Renal fibrosis in feline chronic kidney disease: known mediators and mechanisms of injury

Lawson, J S; Elliott, J; Wheeler-Jones, C P D; Syme, H M; Jepson, R E


J S Lawson

J Elliott

C P D Wheeler-Jones

H M Syme

R E Jepson


Chronic kidney disease (CKD) is a common medical condition of ageing cats. In most cases the underlying aetiology is unknown, but the most frequently reported pathological diagnosis is renal tubulointerstitial fibrosis. Renal fibrosis, characterised by extensive accumulation of extra-cellular matrix within the interstitium, is thought to be the final common pathway for all kidney diseases and is the pathological lesion best correlated with function in both humans and cats. As a convergent pathway, renal fibrosis provides an ideal target for the treatment of CKD and knowledge of the underlying fibrotic process is essential for the future development of novel therapies. There are many mediators and mechanisms of renal fibrosis reported in the literature, of which only a few have been investigated in the cat. This article reviews the process of renal fibrosis and discusses the most commonly cited mediators and mechanisms of progressive renal injury, with particular focus on the potential significance to feline CKD.


Lawson, J. S., Elliott, J., Wheeler-Jones, C. P. D., Syme, H. M., & Jepson, R. E. (2015). Renal fibrosis in feline chronic kidney disease: known mediators and mechanisms of injury.

Journal Article Type Article
Acceptance Date Oct 11, 2014
Publication Date Jan 1, 2015
Deposit Date Nov 11, 2014
Publicly Available Date Nov 11, 2014
Peer Reviewed Peer Reviewed
Volume 203
Issue 1
Pages 18-26
Public URL