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Factors associated with insulin responses to oral sugars in a mixed-breed cohort of ponies (2023)
Journal Article
Knowles, E., Harris, P., Elliott, J., Chang, Y., & Menzies-Gow, N. (2023). Factors associated with insulin responses to oral sugars in a mixed-breed cohort of ponies. Equine Veterinary Journal, https://doi.org/10.1111/evj.13983

Background: Serum insulin concentration at 60 min (InsulinT60) during an oral sugar test (OST) indicates future laminitis risk and insulin dysregulation (ID). Associations between InsulinT60 and physical and owner-reported variables may help clinicia... Read More about Factors associated with insulin responses to oral sugars in a mixed-breed cohort of ponies.

Therapeutics of managing reduced red cell mass associated with chronic kidney disease – is there a case for earlier intervention? (2023)
Journal Article
Elliott, J. (in press). Therapeutics of managing reduced red cell mass associated with chronic kidney disease – is there a case for earlier intervention?. Journal of Veterinary Pharmacology and Therapeutics, https://doi.org/10.1111/jvp.13127

Reduced red cell mass is a poor prognostic indicator in chronic kidney disease (CKD) patients. Whilst overt anaemia impacts on the quality of life of patients with CKD, lowered red cell mass may also compromise oxygen delivery to proximal tubular ce... Read More about Therapeutics of managing reduced red cell mass associated with chronic kidney disease – is there a case for earlier intervention?.

Short Communication: Identification of equine corticotropin-like intermediate lobe peptide (CLIP) binding to an adrenocortipcotrophic hormone (ACTH) assay capture antibody (2023)
Journal Article
Knowles, E., Hyde, C., Harris, P., Elliott, J., & Menzies-Gow, N. (2023). Short Communication: Identification of equine corticotropin-like intermediate lobe peptide (CLIP) binding to an adrenocortipcotrophic hormone (ACTH) assay capture antibody. Domestic Animal Endocrinology, https://doi.org/10.1016/j.domaniend.2023.106785

A chemiluminescent immunoassay is commonly employed to measure adrenocorticotrophic hormone (ACTH) concentrations to assist pituitary pars intermedia dysfunction diagnosis. In a previous study, seasonally dependent assay cross-reactivity to endogenou... Read More about Short Communication: Identification of equine corticotropin-like intermediate lobe peptide (CLIP) binding to an adrenocortipcotrophic hormone (ACTH) assay capture antibody.

Risk factors for upper urinary tract uroliths and ureteral obstruction in cats under referral veterinary care in the United Kingdom (2023)
Journal Article
Geddes, R. F., Davison, L. J., Elliott, J., Syme, H. M., & O'Neill, D. G. (2023). Risk factors for upper urinary tract uroliths and ureteral obstruction in cats under referral veterinary care in the United Kingdom. Journal of Veterinary Internal Medicine, 37(2), 567-577. https://doi.org/10.1111/jvim.16659

Background Cats presenting with upper urinary tract uroliths (UUTUs) and ureteral obstruction (“obstructive UUTU”) are typically younger than cats with idiopathic CKD that often have incidental nephroliths. Hypothesis Cats with upper urinary tra... Read More about Risk factors for upper urinary tract uroliths and ureteral obstruction in cats under referral veterinary care in the United Kingdom.

A review of cellular and molecular mechanisms in endocrinopathic, sepsis-related and supporting limb equine laminitis (2023)
Journal Article
Elliott, J., & Bailey, S. (in press). A review of cellular and molecular mechanisms in endocrinopathic, sepsis-related and supporting limb equine laminitis. Equine Veterinary Journal, https://doi.org/10.1111/evj.13933

Equine laminitis has both fascinated and frustrated veterinary researchers and clinicians for many years. The recognition that many ponies suffering from pasture associated laminitis have an insulin dysregulated phenotype (endocrinopathic laminitis,... Read More about A review of cellular and molecular mechanisms in endocrinopathic, sepsis-related and supporting limb equine laminitis.

A review of cellular and molecular mechanisms in endocrinopathic, sepsis-related and supporting limb equine laminitis (2023)
Journal Article
Elliott, J. (2023). A review of cellular and molecular mechanisms in endocrinopathic, sepsis-related and supporting limb equine laminitis. Equine Veterinary Journal, https://doi.org/10.1111/evj.13933

Equine laminitis has both fascinated and frustrated veterinary researchers and clinicians for many years. The recognition that many ponies suffering from pasture associated laminitis have an insulin dysregulated phenotype (endocrinopathic laminitis,... Read More about A review of cellular and molecular mechanisms in endocrinopathic, sepsis-related and supporting limb equine laminitis.

Predictors of laminitis development in a cohort of nonlaminitic ponies (2023)
Journal Article
Knowles, E., Elliott, J., Harris, P., Chang, Y., & Menzies-Gow, N. (2023). Predictors of laminitis development in a cohort of nonlaminitic ponies. Equine Veterinary Journal, https://doi.org/10.1111/evj.13572

Background Quantifying risk factors for laminitis development requires improvement. Objectives To identify the most useful physical examination, metabolic and management factors to predict laminitis development in client-owned, nonlaminitic ponies. S... Read More about Predictors of laminitis development in a cohort of nonlaminitic ponies.

Ondansetron in dogs with nausea associated with vestibular disease: A double-blinded, randomized placebo-controlled crossover study (2022)
Journal Article
Henze, L., Foth, S., Meller, S., Twele, F., Charalambous, M., Kenward, H., …Volk, H. (2022). Ondansetron in dogs with nausea associated with vestibular disease: A double-blinded, randomized placebo-controlled crossover study. Journal of Veterinary Internal Medicine, https://doi.org/10.1111/jvim.16504

Background: Nausea and emesis can be, among other signs, common manifestations of acute vestibular system dysfunction in dogs. Currently, antiemetic drugs, such as maropitant and metoclopramide, are used commonly, but do not appear to control naus... Read More about Ondansetron in dogs with nausea associated with vestibular disease: A double-blinded, randomized placebo-controlled crossover study.

Nitric oxide synthase inhibition reveals differences in the nitric oxide pathway in previously laminitic ponies. (2022)
Journal Article
Finding, E., Elliott, J., Harris, P., & Menzies-Gow, N. (2022). Nitric oxide synthase inhibition reveals differences in the nitric oxide pathway in previously laminitic ponies. Research in Veterinary Science, https://doi.org/10.1016/j.rvsc.2022.05.012

Previously laminitic (PL) ponies are reported to have higher blood pressure than non laminitic (NL) ponies. This relative hypertension may be related to endothelial cell dysfunction, similar to humans with metabolic syndrome. To investigate the relat... Read More about Nitric oxide synthase inhibition reveals differences in the nitric oxide pathway in previously laminitic ponies..

Ionized hypercalcemia in cats with azotemic chronic kidney disease (2012-2018) (2022)
Journal Article
van den Broek, D., Geddes, R., Lotter, N., Chang, Y., Elliott, J., & Jepson, R. (2022). Ionized hypercalcemia in cats with azotemic chronic kidney disease (2012-2018). Journal of Veterinary Internal Medicine, https://doi.org/10.1111/jvim.16430

Background Hypercalcemia is associated with chronic kidney disease (CKD) in cats, but studies assessing the physiologically relevant ionized calcium fraction are lacking. Objectives To describe the prevalence and incidence rate of ionized hypercalcem... Read More about Ionized hypercalcemia in cats with azotemic chronic kidney disease (2012-2018).

New concepts in phosphorus homeostasis and its impact on renal health with particular reference to the cat (2022)
Journal Article
Elliott, J., & Geddes, R. F. (2022). New concepts in phosphorus homeostasis and its impact on renal health with particular reference to the cat. The Veterinary Journal, 283-284, Article 105842. https://doi.org/10.1016/j.tvjl.2022.105842

New discoveries relating to phosphorus homeostasis include the hormones fibroblast growth factor-23 and klotho produced by bone and kidney. These hormones, together with novel understanding of how calcium and phosphate ions are carried in colloidal f... Read More about New concepts in phosphorus homeostasis and its impact on renal health with particular reference to the cat.

Pharmacology, safety, efficacy and clinical uses of the COX?2 inhibitor robenacoxib (2022)
Journal Article
Lees, P., Toutain, P., Elliott, J., Giraudel, J. M., Pelligand, L., & King, J. N. (2022). Pharmacology, safety, efficacy and clinical uses of the COX?2 inhibitor robenacoxib. Journal of Veterinary Pharmacology and Therapeutics, 45(4), 325-351. https://doi.org/10.1111/jvp.13052

Robenacoxib is a veterinary-approved non-steroidal anti-inflammatory drug (NSAID) of the coxib group. It possesses anti-hyperalgesic, anti-inflammatory and anti-pyretic properties. Robenacoxib inhibits the cyclooxygenase (COX)-2 isoform of COX select... Read More about Pharmacology, safety, efficacy and clinical uses of the COX?2 inhibitor robenacoxib.

First Genome-Wide Association Study Investigating Blood Pressure and Renal Traits in Domestic Cats (2022)
Journal Article
Jepson, R. E., Warren, H., Syme, H. M., Elliott, J., & Munroe, P. B. (2022). First Genome-Wide Association Study Investigating Blood Pressure and Renal Traits in Domestic Cats. Scientific Reports, https://doi.org/10.1038/s41598-022-05494-3

Hypertension (HTN) and chronic kidney disease (CKD) are common in ageing cats. In humans, blood pressure (BP) and renal function are complex heritable traits. We performed the first feline Genome-Wide Association Study (GWAS) of quantitative traits s... Read More about First Genome-Wide Association Study Investigating Blood Pressure and Renal Traits in Domestic Cats.

Risk factors and implications associated with renal mineralization in chronic kidney disease in cats (2022)
Journal Article
Tang, P., Jepson, R., Chang, Y., Geddes, R., Hopkinson, M., & Elliott, J. (2022). Risk factors and implications associated with renal mineralization in chronic kidney disease in cats. Journal of Veterinary Internal Medicine, https://doi.org/10.1111/jvim.16363

Background Nephrocalcinosis is a pathological feature of chronic kidney disease (CKD). Its pathophysiological implications for cats with CKD are unexplored. Objectives Identify nephrocalcinosis risk factors and evaluate its influence on CKD prog... Read More about Risk factors and implications associated with renal mineralization in chronic kidney disease in cats.

Accuracy of history, physical examination, cardiac biomarkers, and biochemical variables in identifying dogs with stage B2 degenerative mitral valve disease (2021)
Journal Article
Wilshaw, J., Rosenthal, S., Wess, G., Dickson, D., Bevilacqua, L., Dutton, E., …Boswood, A. (2021). Accuracy of history, physical examination, cardiac biomarkers, and biochemical variables in identifying dogs with stage B2 degenerative mitral valve disease. Journal of Veterinary Internal Medicine, 35(2), 755-770. https://doi.org/10.1111/jvim.16083

Background Treatment is indicated in dogs with preclinical degenerative mitral valve disease (DMVD) and cardiomegaly (stage B2). This is best diagnosed using echocardiography; however, relying upon this limits access to accurate diagnosis. Objectives... Read More about Accuracy of history, physical examination, cardiac biomarkers, and biochemical variables in identifying dogs with stage B2 degenerative mitral valve disease.

The effect of myxomatous mitral valve disease severity on packed cell volume in dogs (2021)
Journal Article
Wilshaw, J., Stein, M., Lotter, N., Elliott, J., & Boswood, A. (2021). The effect of myxomatous mitral valve disease severity on packed cell volume in dogs. Journal of Small Animal Practice, 62(6), 428-436. https://doi.org/10.1111/jsap.13308

Objectives The aim of this study was to examine whether associations between disease severity and packed cell volume exist in dogs with myxomatous mitral valve disease. Materials and Methods Data were selected from 289 dogs that had been examined at... Read More about The effect of myxomatous mitral valve disease severity on packed cell volume in dogs.

The effect of attenuating dietary phosphate restriction on blood ionized calcium concentrations in cats with chronic kidney disease and ionized hypercalcemia (2021)
Journal Article
Rebecca, F., van den Broek, D., Chang, Y., Biourge, V., Elliott, J., & Jepson, R. (2021). The effect of attenuating dietary phosphate restriction on blood ionized calcium concentrations in cats with chronic kidney disease and ionized hypercalcemia. Journal of Veterinary Internal Medicine, 35(2), 997-1007. https://doi.org/10.1111/jvim.16050

Background Hypercalcemia is commonly observed in cats with azotemic chronic kidney disease (CKD). Dietary phosphate restriction is considered standard of care but may contribute to the development of hypercalcemia. The optimal dietary management stra... Read More about The effect of attenuating dietary phosphate restriction on blood ionized calcium concentrations in cats with chronic kidney disease and ionized hypercalcemia.

Renal Senescence, Telomere Shortening and Nitrosative Stress in Feline Chronic Kidney Disease (2021)
Journal Article
Quimby, J., Erickson, A., Mcleland, S., Cianciolo, R., Maranon, D., Lunn, K., …Bailey, S. (2021). Renal Senescence, Telomere Shortening and Nitrosative Stress in Feline Chronic Kidney Disease. Veterinary Sciences, 8(12), https://doi.org/10.3390/vetsci8120314

Kidney tissues from cats with naturally occurring chronic kidney disease (CKD) and adult and senior cats without CKD were assessed to determine whether telomere shortening and nitrosative stress are associated with senescence in feline CKD. The histo... Read More about Renal Senescence, Telomere Shortening and Nitrosative Stress in Feline Chronic Kidney Disease.

Clinical progression of cats with early-stage chronic kidney disease fed diets with varying protein and phosphorus contents and calcium to phosphorus ratios (2021)
Journal Article
Schauf, S., Coltherd, J., Atwal, J., Gilham, M., Carvell-Miller, L., Renfrew, H., …Bakke, A. (2021). Clinical progression of cats with early-stage chronic kidney disease fed diets with varying protein and phosphorus contents and calcium to phosphorus ratios. Journal of Veterinary Internal Medicine, https://doi.org/10.1111/jvim.16263

Background Dietary protein and phosphorus (P) restriction is the mainstay for nutritional management of chronic kidney disease (CKD). However, adequate restriction levels for cats with early CKD remain unclear. Objectives To investigate responses in... Read More about Clinical progression of cats with early-stage chronic kidney disease fed diets with varying protein and phosphorus contents and calcium to phosphorus ratios.