A review of cellular and molecular mechanisms in endocrinopathic, sepsis-related and supporting limb equine laminitis

Elliott, Jonathan; Bailey, Simon

Abstract

Equine laminitis has both fascinated and frustrated veterinary researchers and clinicians for many years. The recognition that many ponies suffering from pasture associated laminitis have an insulin dysregulated phenotype (endocrinopathic laminitis, EL) and that prolonged insulin and glucose infusions can experimentally induce laminar pathology and functional failure are seminal discoveries in this field. Researchers have studieds the molecular basis for disease pathogenesis in models of EL, sepsis-related laminitis (SRL) and supporting limb laminitis (SLL) and generated much data over the last 15 years. This review attempts to synthesise those data, drawing comparisons between models and naturally occurring disease. A hypothesis is proposed that the basal epithelial cell stress is a central event in each category of laminitis. and that Furthermore, in naturally occurring pasture-associated laminitis, pathways that predominate in each type of laminitis contribute to laminar lamellar pathology to varying extents. Based on the molecular mechanisms determined in experimental models, interactions between these pathways are identified.

Citation

Elliott, J., & Bailey, S. (in press). A review of cellular and molecular mechanisms in endocrinopathic, sepsis-related and supporting limb equine laminitis. Equine Veterinary Journal, https://doi.org/10.1111/evj.13933

• Journal Article Type: Review
• Acceptance Date: Feb 24, 2023
• Online Publication Date: Feb 27, 2023
• Deposit Date: Feb 26, 2023
• Publicly Available Date: Apr 28, 2023
• Print ISSN: 0425-1644
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• DOI: https://doi.org/10.1111/evj.13933