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Pharmacokinetic–pharmacodynamic cutoff values for doxycycline in pigs to support the establishment of clinical breakpoints for antimicrobial susceptibility testing (2025)
Journal Article
Pelligand, L., Toutain, P.-L., Bouquet-Mélou, A., Ferran, A., Roques, B., del Castillo, J., Lees, P., Croubels, S., & Bousquet, E. (2025). Pharmacokinetic–pharmacodynamic cutoff values for doxycycline in pigs to support the establishment of clinical breakpoints for antimicrobial susceptibility testing. Journal of Veterinary Pharmacology and Therapeutics, https://doi.org/10.1111/jvp.13511

This meta-analysis provides a population model of doxycycline (DOXY) disposition in pigs for computation of PK/PD cutoff values corresponding to differing modalities of DOXY administration orally in pigs. This analysis enables establishment of specif... Read More about Pharmacokinetic–pharmacodynamic cutoff values for doxycycline in pigs to support the establishment of clinical breakpoints for antimicrobial susceptibility testing.

Erreurs en anesthésie : enquête et analyse de pratique un jour au bloc opératoire en France (2025)
Journal Article
Fuzier, R., Bordes, J., Basquin, C., Bordes-Demolis, M., Bourgain, J.-L., Campion, S., Fletcher, D., Morau, E., Pelieu, I., Pelligand, L., San Miguel, A., Soufir, L., Untereiner, O., Vacheron, C.-H., Blanié, A., & Picard, J. (online). Erreurs en anesthésie : enquête et analyse de pratique un jour au bloc opératoire en France. Anesthésie & Réanimation, https://doi.org/10.1016/j.anrea.2024.11.003

Phenotype-Specific Semi-Mechanistic Modelling of Florfenicol Time-Kill Curves in G. parasuis Compared to Other Respiratory Pathogens (2025)
Journal Article
Mead, A., Hughes, A., Azzariti, S., Toutain, P.-L., & Pelligand, L. (2025). Phenotype-Specific Semi-Mechanistic Modelling of Florfenicol Time-Kill Curves in G. parasuis Compared to Other Respiratory Pathogens. Journal of Veterinary Pharmacology and Therapeutics, https://doi.org/10.1111/jvp.13500

This study examines the pharmacodynamics (PD) of florfenicol (FFN) for treating porcine respiratory diseases by comparing its effects on Glaesserella parasuis, Actinobacillus pleuropneumoniae, and Pasteurella multocida. In vitro time-kill assays and... Read More about Phenotype-Specific Semi-Mechanistic Modelling of Florfenicol Time-Kill Curves in G. parasuis Compared to Other Respiratory Pathogens.

Population pharmacokinetics modelling for clinical dose adjustment of carboplatin in dogs (2024)
Journal Article
Béguin, J., Mahfoudhi, S., Uzel, M., Rostang, A., Ibish, C., Ferran, A., Pelligand, L., Hulin, A., & Kohlhauer, M. (2024). Population pharmacokinetics modelling for clinical dose adjustment of carboplatin in dogs. BMC Veterinary Research, https://doi.org/10.1186/s12917-024-04404-1

Carboplatin is a human chemotherapeutic agent which is frequently used in dogs for the management of solid tumors. In human patient, its dosage is adjusted carefully, based on the creatinine clearance computation. In dogs however, the pharmacokinetic... Read More about Population pharmacokinetics modelling for clinical dose adjustment of carboplatin in dogs.

Determination of pharmacokinetic-pharmacodynamic cutoff values of oxytetracycline in calves and adult cattle using population pharmacokinetic modelling (2024)
Journal Article
Winter, E., Pelligand, L., Toutain, P.-L., Lees, P., Milanova, A., & Gehring, R. (in press). Determination of pharmacokinetic-pharmacodynamic cutoff values of oxytetracycline in calves and adult cattle using population pharmacokinetic modelling. Frontiers in Microbiology, https://doi.org/10.3389/fmicb.2024.1498219

In Europe, there is currently no harmonized clinical breakpoint for interpretation of antimicrobial susceptibility testing of oxytetracycline in cattle. The objective of this meta-analysis of oxytetracycline pharmacokinetic (PK) data in cattle was to... Read More about Determination of pharmacokinetic-pharmacodynamic cutoff values of oxytetracycline in calves and adult cattle using population pharmacokinetic modelling.

Hollow-fibre infection model: adaptations for the culture and assessment of fastidious organisms (2024)
Journal Article
Mead, A., Azzariti, S., & Pelligand, L. (2024). Hollow-fibre infection model: adaptations for the culture and assessment of fastidious organisms. Access Microbiology, 6(6), https://doi.org/10.1099/acmi.0.000744.v3

The Hollow-fibre Infection Model (HFIM) is a valuable in vitro platform for emulating antimicrobial drug (AMD) pharmacokinetic (PK) profiles. Despite its potential, standardized protocols for HFIM operation, especially concerning fastidious organisms... Read More about Hollow-fibre infection model: adaptations for the culture and assessment of fastidious organisms.

Population pharmacokinetic meta-analysis to support dosing regimen in dogs for surgical antimicrobial prophylaxis (2024)
Journal Article
Pelligand, L., Møller Sørensen, T., Cagnardi, P., Toutain, P.-L., & Allerton, F. (in press). Population pharmacokinetic meta-analysis to support dosing regimen in dogs for surgical antimicrobial prophylaxis. The Veterinary Journal, https://doi.org/10.1016/j.tvjl.2024.106136

The Pharmacokinetic/Pharmacodynamic of antimicrobial drugs (AMD) for surgical prophylaxis has been poorly studied, hampering evidence-based decision making around AMD dosing and timing. Our objective is to use PK/PD principles to inform (i) the timin... Read More about Population pharmacokinetic meta-analysis to support dosing regimen in dogs for surgical antimicrobial prophylaxis.

Antimicrobial residues in meat from chickens in Northeast Vietnam: analytical validation and pilot study for sampling optimisation (2024)
Journal Article
Pelligand, L., Hedges, S., Cheng, L., Seow, K., Thi, T. H., Huong, L. Q., Son, D. T., Thanh, H. P. T., Cheah, Y. C., Wang, Y., Hurtaud-Pessel, D., Conan, A., Fournié, G., Blake, D., & Tomley, F. (2024). Antimicrobial residues in meat from chickens in Northeast Vietnam: analytical validation and pilot study for sampling optimisation. Journal für Verbraucherschutz und Lebensmittelsicherheit, https://doi.org/10.1007/s00003-024-01478-9

Antimicrobials used in chicken farming for therapeutic and/or prophylactic purposes may result in unacceptable levels of edible residues, if withdrawal periods are not respected. To evaluate the risk in Vietnam, we validated an analytical methods to... Read More about Antimicrobial residues in meat from chickens in Northeast Vietnam: analytical validation and pilot study for sampling optimisation.

Effect of meloxicam or robenacoxib administration timing on renal function and postoperative analgesia in cats undergoing ovariohysterectomy: A randomized, blinded, controlled clinical trial (2024)
Journal Article
Krekis, A., King, J., D'Arcy-Howard, D., Stapleton, N., Elliott, J., & Pelligand, L. (2024). Effect of meloxicam or robenacoxib administration timing on renal function and postoperative analgesia in cats undergoing ovariohysterectomy: A randomized, blinded, controlled clinical trial. Journal of Veterinary Pharmacology and Therapeutics, https://doi.org/10.1111/jvp.13427

We evaluated the effect of administration timing of meloxicam and robenacoxib on renal function, platelet cyclo-oxygenase and perioperative analgesia in 60 cats undergoing ovariohysterectomy, in a prospective randomized blinded controlled study. Twel... Read More about Effect of meloxicam or robenacoxib administration timing on renal function and postoperative analgesia in cats undergoing ovariohysterectomy: A randomized, blinded, controlled clinical trial.

Effect of timing of pre-emptive administration of meloxicam and robenacoxib for feline ovariectomy on perioperative renal homeostasis, clotting function and perioperative analgesia; a randomised, blinded, controlled clinical trial (2024)
Journal Article
Krekis, A., King, J. N., D'Arcy-Howard, D., Stapleton, N., Elliott, J., & Pelligand, L. (in press). Effect of timing of pre-emptive administration of meloxicam and robenacoxib for feline ovariectomy on perioperative renal homeostasis, clotting function and perioperative analgesia; a randomised, blinded, controlled clinical trial. Veterinary Anaesthesia and Analgesia, https://doi.org/10.1111/jvp.13427

Please find attached our paper for review entitled 'Effect of timing of pre-emptive 12 administration of meloxicam and robenacoxib for feline ovariectomy on perioperative renal 13 homeostasis, clotting function and perioperative analgesia; a randomis... Read More about Effect of timing of pre-emptive administration of meloxicam and robenacoxib for feline ovariectomy on perioperative renal homeostasis, clotting function and perioperative analgesia; a randomised, blinded, controlled clinical trial.

Targeted dosing for susceptible heteroresistant subpopulations may improve rational dosage regimen prediction for colistin in broiler chickens (2023)
Journal Article
Mead, A., Toutain, P.-L., Richez, P., & Pelligand, L. (2023). Targeted dosing for susceptible heteroresistant subpopulations may improve rational dosage regimen prediction for colistin in broiler chickens. Scientific Reports, 13, Article 12822. https://doi.org/10.1038/s41598-023-39727-w

The dosage of colistin for the treatment of enteric E. coli in animals necessitates considering the heteroresistant (HR) nature of the targeted inoculum, described by the presence of a major susceptible population (S1, representing 99.95% of total po... Read More about Targeted dosing for susceptible heteroresistant subpopulations may improve rational dosage regimen prediction for colistin in broiler chickens.

Are there substandard amoxicillin/clavulanic acid oral formulations for intended veterinary use in Malaysia, the United Kingdom, Serbia and Thailand? A convenience sampling study (2023)
Journal Article
Pelligand, L., Baker, D., Sivagurunathan, A., Kovačević, Z., Suemanotham, N., Stair, J. L., Scott, M., Liu, F., Page, S., Guardabassi, L., & Steagall, P. V. (in press). Are there substandard amoxicillin/clavulanic acid oral formulations for intended veterinary use in Malaysia, the United Kingdom, Serbia and Thailand? A convenience sampling study. Journal of Small Animal Practice, https://doi.org/10.1111/jsap.13648

Objectives: Antimicrobial formulations of substandard quality have negative consequences for efficacy in patients and potentially promote antimicrobial resistance. Amoxicillin/clavulanate (AMC) is the most commonly used oral antimicrobial drug in com... Read More about Are there substandard amoxicillin/clavulanic acid oral formulations for intended veterinary use in Malaysia, the United Kingdom, Serbia and Thailand? A convenience sampling study.

Control of a sulfadoxine/trimethoprim combination in the competition horse: Elimination, metabolism and detection following an intravenous administration (2023)
Journal Article
Schenk, I., Broussou, D., Roques, B., Lagershausen, H., Machnik, M., Röttgen, H., Toutain, P., & Thevis, M. (2023). Control of a sulfadoxine/trimethoprim combination in the competition horse: Elimination, metabolism and detection following an intravenous administration. Drug Testing and Analysis, https://doi.org/10.1002/dta.3461

Doxycycline serum protein binding in pigs reveals a relatively high free fraction (2023)
Journal Article
Felipe Ramon, P., Marlène Z., L., Béatrice B., R., Véronique, G., Pierre-Louis, T., & Bousquet-Mélou, A. (2023). Doxycycline serum protein binding in pigs reveals a relatively high free fraction. Journal of Veterinary Pharmacology and Therapeutics, https://doi.org/10.1111/jvp.13111

Doxycycline is an antibiotic widely used in pig farming, which leads to update the doses using PK/PD concepts. However, there is an impasse to estimate the PK/PD cut-off of doxycycline in pigs. Indeed, considering its 7% free fraction and the total s... Read More about Doxycycline serum protein binding in pigs reveals a relatively high free fraction.

Biased computation of Probability of Target Attainment for antimicrobial drugs (2023)
Journal Article
Toutain, P.-L., Pelligand, L., Gandia, P., Ferran, A., Lees, P., Bousquet-Melou, A., & Concordet, D. (in press). Biased computation of Probability of Target Attainment for antimicrobial drugs. Clinical Pharmacology and Therapeutics,

The medical literature is replete with articles in which there is confusion between “free concentration” and “free fraction” (fu), which is the ratio of free to total plasma concentration. The lack of clarity in distinguishing between these two terms... Read More about Biased computation of Probability of Target Attainment for antimicrobial drugs.