Effect of meloxicam or robenacoxib administration timing on renal function and postoperative analgesia in cats undergoing ovariohysterectomy: A randomized, blinded, controlled clinical trial

Krekis, A; King, JN; D'Arcy-Howard, D; Stapleton, N; Elliott, J; Pelligand, L

doi:10.1111/jvp.13427

Population pharmacokinetics modelling for clinical dose adjustment of carboplatin in dogs (2024)
Journal Article
Béguin, J., Mahfoudhi, S., Uzel, M., Rostang, A., Ibish, C., Ferran, A., Pelligand, L., Hulin, A., & Kohlhauer, M. (2024). Population pharmacokinetics modelling for clinical dose adjustment of carboplatin in dogs. BMC Veterinary Research, https://doi.org/10.1186/s12917-024-04404-1

Carboplatin is a human chemotherapeutic agent which is frequently used in dogs for the management of solid tumors. In human patient, its dosage is adjusted carefully, based on the creatinine clearance computation. In dogs however, the pharmacokinetic... Read More about Population pharmacokinetics modelling for clinical dose adjustment of carboplatin in dogs.

Determination of pharmacokinetic-pharmacodynamic cutoff values of oxytetracycline in calves and adult cattle using population pharmacokinetic modelling (2024)
Journal Article
Winter, E., Pelligand, L., Toutain, P.-L., Lees, P., Milanova, A., & Gehring, R. (in press). Determination of pharmacokinetic-pharmacodynamic cutoff values of oxytetracycline in calves and adult cattle using population pharmacokinetic modelling. Frontiers in Microbiology, https://doi.org/10.3389/fmicb.2024.1498219

In Europe, there is currently no harmonized clinical breakpoint for interpretation of antimicrobial susceptibility testing of oxytetracycline in cattle. The objective of this meta-analysis of oxytetracycline pharmacokinetic (PK) data in cattle was to... Read More about Determination of pharmacokinetic-pharmacodynamic cutoff values of oxytetracycline in calves and adult cattle using population pharmacokinetic modelling.

Hollow-fibre infection model: adaptations for the culture and assessment of fastidious organisms (2024)
Journal Article
Mead, A., Azzariti, S., & Pelligand, L. (2024). Hollow-fibre infection model: adaptations for the culture and assessment of fastidious organisms. Access Microbiology, 6(6), https://doi.org/10.1099/acmi.0.000744.v3

The Hollow-fibre Infection Model (HFIM) is a valuable in vitro platform for emulating antimicrobial drug (AMD) pharmacokinetic (PK) profiles. Despite its potential, standardized protocols for HFIM operation, especially concerning fastidious organisms... Read More about Hollow-fibre infection model: adaptations for the culture and assessment of fastidious organisms.

Population pharmacokinetic meta-analysis to support dosing regimen in dogs for surgical antimicrobial prophylaxis (2024)
Journal Article
Pelligand, L., Møller Sørensen, T., Cagnardi, P., Toutain, P.-L., & Allerton, F. (in press). Population pharmacokinetic meta-analysis to support dosing regimen in dogs for surgical antimicrobial prophylaxis. The Veterinary Journal, https://doi.org/10.1016/j.tvjl.2024.106136

The Pharmacokinetic/Pharmacodynamic of antimicrobial drugs (AMD) for surgical prophylaxis has been poorly studied, hampering evidence-based decision making around AMD dosing and timing. Our objective is to use PK/PD principles to inform (i) the timin... Read More about Population pharmacokinetic meta-analysis to support dosing regimen in dogs for surgical antimicrobial prophylaxis.

Why the racing industry and equestrian disciplines need to implement population pharmacokinetics: To learn, explain, summarize, harmonize, and individualize (2024)
Journal Article
Toutain, P. (2024). Why the racing industry and equestrian disciplines need to implement population pharmacokinetics: To learn, explain, summarize, harmonize, and individualize. Drug Testing and Analysis, https://doi.org/10.1002/dta.3706

Reply to: Letter to the Editor from Malik et al: Acute kidney injury following subcutaneous meloxicam administration (2024)
Journal Article
Pelligand, L., King, J., Stapleton, N., D'Arcy-Howard, D., Elliott, J., & Krekis, A. (in press). Reply to: Letter to the Editor from Malik et al: Acute kidney injury following subcutaneous meloxicam administration. Journal of Veterinary Pharmacology and Therapeutics, https://doi.org/10.1111/jvp.13438

Antimicrobial residues in meat from chickens in Northeast Vietnam: analytical validation and pilot study for sampling optimisation (2024)
Journal Article
Pelligand, L., Hedges, S., Cheng, L., Seow, K., Thi, T. H., Huong, L. Q., Son, D. T., Thanh, H. P. T., Cheah, Y. C., Wang, Y., Hurtaud-Pessel, D., Conan, A., Fournié, G., Blake, D., & Tomley, F. (2024). Antimicrobial residues in meat from chickens in Northeast Vietnam: analytical validation and pilot study for sampling optimisation. Journal für Verbraucherschutz und Lebensmittelsicherheit, https://doi.org/10.1007/s00003-024-01478-9

Antimicrobials used in chicken farming for therapeutic and/or prophylactic purposes may result in unacceptable levels of edible residues, if withdrawal periods are not respected. To evaluate the risk in Vietnam, we validated an analytical methods to... Read More about Antimicrobial residues in meat from chickens in Northeast Vietnam: analytical validation and pilot study for sampling optimisation.

Effect of timing of pre-emptive administration of meloxicam and robenacoxib for feline ovariectomy on perioperative renal homeostasis, clotting function and perioperative analgesia; a randomised, blinded, controlled clinical trial (2024)
Journal Article
Krekis, A., King, J. N., D'Arcy-Howard, D., Stapleton, N., Elliott, J., & Pelligand, L. (in press). Effect of timing of pre-emptive administration of meloxicam and robenacoxib for feline ovariectomy on perioperative renal homeostasis, clotting function and perioperative analgesia; a randomised, blinded, controlled clinical trial. Veterinary Anaesthesia and Analgesia, https://doi.org/10.1111/jvp.13427

Please find attached our paper for review entitled 'Effect of timing of pre-emptive 12 administration of meloxicam and robenacoxib for feline ovariectomy on perioperative renal 13 homeostasis, clotting function and perioperative analgesia; a randomis... Read More about Effect of timing of pre-emptive administration of meloxicam and robenacoxib for feline ovariectomy on perioperative renal homeostasis, clotting function and perioperative analgesia; a randomised, blinded, controlled clinical trial.

Effect of meloxicam or robenacoxib administration timing on renal function and postoperative analgesia in cats undergoing ovariohysterectomy: A randomized, blinded, controlled clinical trial (2024)
Journal Article
Krekis, A., King, J., D'Arcy-Howard, D., Stapleton, N., Elliott, J., & Pelligand, L. (2024). Effect of meloxicam or robenacoxib administration timing on renal function and postoperative analgesia in cats undergoing ovariohysterectomy: A randomized, blinded, controlled clinical trial. Journal of Veterinary Pharmacology and Therapeutics, https://doi.org/10.1111/jvp.13427

We evaluated the effect of administration timing of meloxicam and robenacoxib on renal function, platelet cyclo-oxygenase and perioperative analgesia in 60 cats undergoing ovariohysterectomy, in a prospective randomized blinded controlled study. Twel... Read More about Effect of meloxicam or robenacoxib administration timing on renal function and postoperative analgesia in cats undergoing ovariohysterectomy: A randomized, blinded, controlled clinical trial.

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