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All Outputs (15)

Physics of Animal Health: On the mechano-biology of hoof growth and form (2019)
Journal Article
Al-Agele, R., Paul, E., Taylor, S., Watson, C., Sturrock, C., Drakopoulos, M., Atwood, R. C., Rutland, C. S., Menzies-Gow, N. J., Knowles, E., Elliott, J., Harris, P., & Rauch, C. (2019). Physics of Animal Health: On the mechano-biology of hoof growth and form. https://doi.org/10.1098/rsif.2019.0214

Global inequalities in economic access and agriculture productivity imply that a large number of developing countries rely on working equids for transport/agriculture/mining. Therefore, the understanding of hoof conditions/shape variations affecting... Read More about Physics of Animal Health: On the mechano-biology of hoof growth and form.

Cell specific microvesicles vary with season and disease predisposition in healthy and previously laminitic ponies (2018)
Journal Article
Finding, E. J. T., Lawson, C., Elliott, J., Harris, P. A., & Menzies-Gow, N. J. (2018). Cell specific microvesicles vary with season and disease predisposition in healthy and previously laminitic ponies. Veterinary Immunology and Immunopathology, https://doi.org/10.1016/j.vetimm.2018.06.001

Microvesicles are small (up to 1 μm) vesicles found in plasma and other bodily fluids. They are recognised as part of the normal system of inter-cellular communication but altered numbers are also used as biomarkers of disease. Microvesicles have not... Read More about Cell specific microvesicles vary with season and disease predisposition in healthy and previously laminitic ponies.

Seasonal and dietary influences on adipose tissue and systemic gene expression in control and previously laminitic ponies (2018)
Journal Article
Timpson, A., De Mestre, A. M., Elliott, J., Harris, P. A., Cheng, Z. R., Mirczuk, S. M., Callan, L., Rainbow, L., & Menzies-Gow, N. J. (2018). Seasonal and dietary influences on adipose tissue and systemic gene expression in control and previously laminitic ponies. Journal of Equine Veterinary Science, https://doi.org/10.1016/j.jevs.2018.06.009

The aims of the study were to determine whether adipose tissue global gene expression (i) differs between never laminitic (NL) and previously laminitic (PL) ponies; (ii) is influenced by season and/or a diet designed to simulate spring grass and (iii... Read More about Seasonal and dietary influences on adipose tissue and systemic gene expression in control and previously laminitic ponies.

Plasma adrenocorticotropic hormone (ACTH) concentrations in ponies measured by two different assays suggests seasonal cross reactivity or interference (2018)
Journal Article
Knowles, E. J., Moreton-Clack, M. C., Shaw, S., Harris, P. A., Elliott, J., & Menzies-Gow, N. J. (2018). Plasma adrenocorticotropic hormone (ACTH) concentrations in ponies measured by two different assays suggests seasonal cross reactivity or interference. Equine Veterinary Journal, 50(5), 672-677. https://doi.org/10.1111/evj.12797

Use of the oral sugar test in ponies when performed with or without prior fasting (2016)
Journal Article
Knowles, E. J., Harris, P. A., Elliott, J., & Menzies-Gow, N. J. (2016). Use of the oral sugar test in ponies when performed with or without prior fasting. Equine Veterinary Journal, 49, 519-524. https://doi.org/10.1111/evj.12607

Background
It is recommended that the Oral Sugar Test (OST) for insulin dysregulation (ID) is performed after an overnight fast but fasting is impractical in ponies kept solely at pasture. There are few data on OST repeatability and reliability in p... Read More about Use of the oral sugar test in ponies when performed with or without prior fasting.

Evaluation of the induction of vasoactive mediators from equine digital vein endothelial cells by endotoxin
Journal Article
Menzies-Gow, N. J., Bailey, S. R., Berhane, Y., Brooks, A. C., & Elliott, J. Evaluation of the induction of vasoactive mediators from equine digital vein endothelial cells by endotoxin. American Journal of Veterinary Research, 69(3), 349-355

Objective - To determine the effect of endotoxin (lipopolysaccharide [LPS]) on vasoactive mediator production by cultured equine digital vein endothelial cells (EDVECs). Sample Population - EDVECs obtained from forelimb digital veins of 7 healthy adu... Read More about Evaluation of the induction of vasoactive mediators from equine digital vein endothelial cells by endotoxin.

Roles of thromboxane A2 and 5-hydroxytryptamine in endotoxin-induced digital vasoconstriction in horses
Journal Article
Menzies-Gow, N. J., Sepulveda, M. F., Bailey, S. R., Cunningham, F. M., & Elliott, J. Roles of thromboxane A2 and 5-hydroxytryptamine in endotoxin-induced digital vasoconstriction in horses. American Journal of Veterinary Research, 69(2), 199-207. https://doi.org/10.2460/ajvr.69.2.199

Objective-To evaluate the roles of 5-hydroxytryptamine (5-HT), thromboxane A(2) (TxA(2) and platelet-activating factor (PAF) in endotoxin-induced digital hypoperfusion in horses. Animals-6 healthy adult Thoroughbreds. Procedures-Horses were treated w... Read More about Roles of thromboxane A2 and 5-hydroxytryptamine in endotoxin-induced digital vasoconstriction in horses.

Regulation of platelet activating factor-induced equine platelet activation by intracellular kinases
Journal Article
Brooks, A. C., Menzies-Gow, N. J., Wheeler-Jones, C. P. D., Bailey, S. R., Elliott, J., & Cunningham, F. M. Regulation of platelet activating factor-induced equine platelet activation by intracellular kinases. Journal of Veterinary Pharmacology and Therapeutics, 32(2), 189-196. https://doi.org/10.1111/j.1365-2885.2008.01020.x

Lipopolysaccharide (LPS) can activate equine platelets directly or indirectly, via leukocyte-derived platelet activating factor (PAF). Thromboxane (Tx) production by LPS-stimulated equine platelets requires p38 MAPK and this kinase has been suggested... Read More about Regulation of platelet activating factor-induced equine platelet activation by intracellular kinases.

Hypertension and insulin resistance in a mixed-breed population of ponies predisposed to laminitis
Journal Article
Bailey, S. R., Habershon-Butcher, J. L., Ransom, K. J., Elliott, J., & Menzies-Gow, N. J. Hypertension and insulin resistance in a mixed-breed population of ponies predisposed to laminitis. American Journal of Veterinary Research, 69(1), 122-129. https://doi.org/10.2460/ajvr.69.1.122

Objective - To determine the metabolic phenotype of a group of laminitis-prone ponies when at pasture in summer, compared with when at pasture in winter. Animals - 40 ponies of various breeds predisposed to recurrent pasture-associated laminitis and... Read More about Hypertension and insulin resistance in a mixed-breed population of ponies predisposed to laminitis.