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Delivery of chondroitinase by canine mucosal olfactory ensheathing cells alongside rehabilitation enhances recovery after spinal cord injury (2021)
Journal Article
Prager, J., Ito, D., Carwardine, D. R., Jiju, P., Chari, D. M., Granger, N., & Wong, L. (in press). Delivery of chondroitinase by canine mucosal olfactory ensheathing cells alongside rehabilitation enhances recovery after spinal cord injury. Experimental Neurology, https://doi.org/10.1016/j.expneurol.2021.113660

Spinal cord injury (SCI) can cause chronic paralysis and incontinence and remains a major worldwide healthcare burden, with no regenerative treatment clinically available. Intraspinal transplantation of olfactory ensheathing cells (OECs) and inject... Read More about Delivery of chondroitinase by canine mucosal olfactory ensheathing cells alongside rehabilitation enhances recovery after spinal cord injury.

Emerging and Adjunctive Therapies for Spinal Cord Injury Following Acute Canine Intervertebral Disc Herniation (2020)
Journal Article
Lewis, M. J., Granger, N., Jeffery, N. D., & The Canine Spinal Cord Injury Consortium (CANSORT-SCI), . (2020). Emerging and Adjunctive Therapies for Spinal Cord Injury Following Acute Canine Intervertebral Disc Herniation. Frontiers in Veterinary Science, 7, 579933

Some dogs do not make a full recovery following medical or surgical management of acute canine intervertebral disc herniation (IVDH), highlighting the limits of currently available treatment options. The multitude of difficulties in treating severe s... Read More about Emerging and Adjunctive Therapies for Spinal Cord Injury Following Acute Canine Intervertebral Disc Herniation.

Current Approaches to the Management of Acute Thoracolumbar Disc Extrusion in Dogs (2020)
Journal Article
Moore, S. A., Tipold, A., Olby, N. J., Stein, V., & Granger, N. (2020). Current Approaches to the Management of Acute Thoracolumbar Disc Extrusion in Dogs. Frontiers in Veterinary Science, 7, 610

Intervertebral disc extrusion (IVDE) is one of the most common neurologic problems encountered in veterinary clinical practice. The purpose of this manuscript is to provide an overview of the literature related to treatment of acute canine thoracolum... Read More about Current Approaches to the Management of Acute Thoracolumbar Disc Extrusion in Dogs.

Charcot-Marie-Tooth type 4B2 demyelinating neuropathy in miniature Schnauzer dogs caused by a novel splicing SBF2 (MTMR13) genetic variant: a new spontaneous clinical model (2019)
Journal Article
Granger, N., Feliu-Pascual, A., Spicer, C., Ricketts, S., Hitti, R., Forman, O., …Houlden, H. (2019). Charcot-Marie-Tooth type 4B2 demyelinating neuropathy in miniature Schnauzer dogs caused by a novel splicing SBF2 (MTMR13) genetic variant: a new spontaneous clinical model. PeerJ, 7, e7983. https://doi.org/10.7717/peerj.7983

This study reports the first genetic variant in Miniature Schnauzer dogs responsible for the occurrence of a demyelinating peripheral neuropathy with abnormally folded myelin. This discovery establishes a genotype/phenotype correlation in affected Mi... Read More about Charcot-Marie-Tooth type 4B2 demyelinating neuropathy in miniature Schnauzer dogs caused by a novel splicing SBF2 (MTMR13) genetic variant: a new spontaneous clinical model.

Somatosensory and motor evoked potentials in dogs with chronic severe thoracolumbar spinal cord injury (2018)
Journal Article
Zu, H. Z., Jeffery, N. D., & Granger, N. (2018). Somatosensory and motor evoked potentials in dogs with chronic severe thoracolumbar spinal cord injury. https://doi.org/10.1016/j.tvjl.2018.05.007

ome dogs that become paraplegic after severe spinal cord injury regain ambulation on the pelvic limbs despite permanent loss of pelvic limb sensation, a phenomenon termed ‘spinal walking’. Plastic changes in spinal cord circuitry are thought to media... Read More about Somatosensory and motor evoked potentials in dogs with chronic severe thoracolumbar spinal cord injury.

25-Hydroxy vitamin D3 serum concentration in dogs with acute polyradiculoneuritis compared to matched controls (2018)
Journal Article
Laws, E. J., Kathrani, A., Harcourt-Brown, T. R., Granger, N., & Rose, J. H. (2018). 25-Hydroxy vitamin D3 serum concentration in dogs with acute polyradiculoneuritis compared to matched controls. Journal of Small Animal Practice, 59(4), 222-227. https://doi.org/10.1111/jsap.12791

Objectives To determine if dogs with acute polyradiculoneuritis have lower serum 25-hydroxy vitamin D3 concentration compared to a control group of dogs with idiopathic epilepsy. Materials and Methods Retrospective case–control study of 21 dogs... Read More about 25-Hydroxy vitamin D3 serum concentration in dogs with acute polyradiculoneuritis compared to matched controls.

Therapeutic efficacy of microtube-embedded chondroitinase ABC in a canine clinical model of spinal cord injury (2018)
Journal Article
Hu, H. Z., Granger, N., Pai, S. B., Bellamkonda, R. V., & Jeffery, N. D. (2018). Therapeutic efficacy of microtube-embedded chondroitinase ABC in a canine clinical model of spinal cord injury. Brain, 141, 1017-1027. https://doi.org/10.1093/brain/awy007

Many hundreds of thousands of people around the world are living with the long-term consequences of spinal cord injury and they need effective new therapies. Laboratory research in experimental animals has identified a large number of potentially tra... Read More about Therapeutic efficacy of microtube-embedded chondroitinase ABC in a canine clinical model of spinal cord injury.

Transplantation of canine olfactory ensheathing cells producing chondroitinase ABC promotes chondroitin sulphate proteoglycan digestion and axonal sprouting following spinal cord injury (2017)
Journal Article
Carwardine, D., Prager, J., Neeves, J., Muir, E. M., Uney, J., Granger, N., & Wong, L. F. (2017). Transplantation of canine olfactory ensheathing cells producing chondroitinase ABC promotes chondroitin sulphate proteoglycan digestion and axonal sprouting following spinal cord injury. PLoS ONE, 12(12), https://doi.org/10.1371/journal.pone.0188967

Olfactory ensheathing cell (OEC) transplantation is a promising strategy for treating spinal cord injury (SCI), as has been demonstrated in experimental SCI models and naturally occurring SCI in dogs. However, the presence of chondroitin sulphate pro... Read More about Transplantation of canine olfactory ensheathing cells producing chondroitinase ABC promotes chondroitin sulphate proteoglycan digestion and axonal sprouting following spinal cord injury.

Dogs with macroadenomas have lower body temperature and heart rate than dogs with microadenomas (2017)
Journal Article
Benchekroun, G., Desquilbet, L., Herrtage, M. E., Jeffery, N. D., Rosenberg, D., & Granger, N. (2017). Dogs with macroadenomas have lower body temperature and heart rate than dogs with microadenomas. The Veterinary Journal, 227, 42-45. https://doi.org/10.1016/j.tvjl.2017.08.007

Pituitary macroadenomas compress the hypothalamus, which partly regulates heart rate and body temperature. The aim of this study was to investigate whether heart rate and/or body temperature could aid in clinically differentiating dogs with macroaden... Read More about Dogs with macroadenomas have lower body temperature and heart rate than dogs with microadenomas.

A fusion of minicircle DNA and nanoparticle delivery technologies facilitates therapeutic genetic engineering of autologous canine olfactory mucosal cells (2017)
Journal Article
Delaney, A. M., Adams, C. F., Fernandes, A. R., Al-Shakli, A. F., Sen, J., Carwardine, D. R., …Chari, D. M. (2017). A fusion of minicircle DNA and nanoparticle delivery technologies facilitates therapeutic genetic engineering of autologous canine olfactory mucosal cells. Nanoscale, 9(25), 8560-8566. https://doi.org/10.1039/c7nr00811b

Olfactory ensheathing cells (OECs) promote axonal regeneration and improve locomotor function when transplanted into the injured spinal cord. A recent clinical trial demonstrated improved motor function in domestic dogs with spinal injury following a... Read More about A fusion of minicircle DNA and nanoparticle delivery technologies facilitates therapeutic genetic engineering of autologous canine olfactory mucosal cells.

Canine olfactory ensheathing cells from the olfactory mucosa can be engineered to produce active chondroitinase ABC (2016)
Journal Article
Carwardine, D., Wong, L. F., Fawcett, J. W., Muir, E. M., & Granger, N. (2016). Canine olfactory ensheathing cells from the olfactory mucosa can be engineered to produce active chondroitinase ABC. Journal of the Neurological Sciences, 367, 311-8. https://doi.org/10.1016/j.jns.2016.06.011

A multitude of factors must be overcome following spinal cord injury (SCI) in order to achieve clinical improvement in patients. It is thought that by combining promising therapies these diverse factors could be combatted with the aim of producing an... Read More about Canine olfactory ensheathing cells from the olfactory mucosa can be engineered to produce active chondroitinase ABC.

Nanoparticle-Based Imaging of Clinical Transplant Populations Encapsulated in Protective Polymer Matrices
Journal Article
Adams, C. F., Delaney, A. M., Carwardine, D. R., Tickle, J., Granger, N., & Chari, D. M. (in press). Nanoparticle-Based Imaging of Clinical Transplant Populations Encapsulated in Protective Polymer Matrices. Macromolecular Bioscience, 19(2), https://doi.org/10.1002/mabi.201800389

A recent clinical trial proved that autologous olfactory mucosal cell (OMC) transplantation improved locomotion in dogs with naturally occurring spinal injuries comparable to human lesions. However, not all dogs responded to the treatment, likely due... Read More about Nanoparticle-Based Imaging of Clinical Transplant Populations Encapsulated in Protective Polymer Matrices.

Methods of olfactory ensheathing cell harvesting from the olfactory mucosa in dogs
Journal Article
Ito, D., Carwardine, D., Prager, J., Wong, L. F., Kitagawa, M., Jeffery, N., & Granger, N. (in press). Methods of olfactory ensheathing cell harvesting from the olfactory mucosa in dogs. PLoS ONE, 14(3), e0213252. https://doi.org/10.1371/journal.pone.0213252

Olfactory ensheathing cells are thought to support regeneration and remyelination of damaged axons when transplanted into spinal cord injuries. Following transplantation, improved locomotion has been detected in many laboratory models and in dogs wit... Read More about Methods of olfactory ensheathing cell harvesting from the olfactory mucosa in dogs.