All Outputs (3)

Microglia contribute to the production of the amyloidogenic ABri peptide in familial British dementia (2024)
Journal Article
Arber, C., Casey, J., Crawford, S., Rambarack, N., Yaman, U., Wiethoff, S., Augustin, E., Piers, T., Price, M., Rostagno, A., Ghiso, J., Lewis, P., Revesz, T., Hardy, J., Pocock, J., Houlden, H., Schott, J., Salih, D., Lashley, T., & Wray, S. (2024). Microglia contribute to the production of the amyloidogenic ABri peptide in familial British dementia. Acta Neuropathologica, 148(1), https://doi.org/10.1007/s00401-024-02820-z

Mutations in ITM2B cause familial British, Danish, Chinese, and Korean dementias. In familial British dementia (FBD), a mutation in the stop codon of the ITM2B gene (also known as BRI2) causes a C-terminal cleavage fragment of the ITM2B/BRI2 protein... Read More about Microglia contribute to the production of the amyloidogenic ABri peptide in familial British dementia.

LRRK2 kinase activity is necessary for development and regeneration in Nematostella vectensis (2024)
Journal Article
Holmes, G., Ferguson, S., Lewis, P., & Echeverri, K. (2024). LRRK2 kinase activity is necessary for development and regeneration in Nematostella vectensis. Neural Development, 19(1), https://doi.org/10.1186/s13064-024-00193-3

Background The starlet sea anemone, Nematostella vectensis, is an emerging model organism with a high regenerative capacity, which was recently found to possess an orthologue to the human Leucine Rich Repeat Kinase 2 (LRRK2) gene. Mutations in this g... Read More about LRRK2 kinase activity is necessary for development and regeneration in Nematostella vectensis.

Common genetic risk for Parkinson's disease and dysfunction of the endo-lysosomal system (2024)
Journal Article
Bhore, N., Bogacki, E., OCallaghan, B., Plun-Favreau, H., Lewis, P., & Herbst, S. (2024). Common genetic risk for Parkinson's disease and dysfunction of the endo-lysosomal system. Philosophical Transactions of the Royal Society B: Biological Sciences, 379(1899), https://doi.org/10.1098/rstb.2022.0517

Parkinson's disease is a progressive neurological disorder, characterized by prominent movement dysfunction. The past two decades have seen a rapid expansion of our understanding of the genetic basis of Parkinson's, initially through the identificati... Read More about Common genetic risk for Parkinson's disease and dysfunction of the endo-lysosomal system.