Safety of oral robenacoxib in the cat

King, J N; Hotz, R; Reagan, E L; Roth, D R; Seewald, W; Lees, P

doi:10.1111/j.1365-2885.2011.01320.x

Comparison of standardised versus non-standardised methods for testing the in vitro potency of oxytetracycline against mannheimia haemolytica and pasteurella multocida (2016)
Journal Article
Lees, P., Illambas, J., Pelligand, L., & Toutain, P. L. (2016). Comparison of standardised versus non-standardised methods for testing the in vitro potency of oxytetracycline against mannheimia haemolytica and pasteurella multocida. https://doi.org/10.1016/j.tvjl.2016.11.006

Activity of florfenicol for Actinobacillus pleuropneumoniae and Pasteurella multocida using standardised versus non-standardised methodology (2016)
Journal Article
Dorey, L., Hobson, S., & Lees, P. (2016). Activity of florfenicol for Actinobacillus pleuropneumoniae and Pasteurella multocida using standardised versus non-standardised methodology. https://doi.org/10.1016/j.tvjl.2016.11.004

Veterinary Medicine Needs New Green Antimicrobial Drugs (2016)
Journal Article
Toutain, P. L., Ferran, A. A., Bousquet-Mélou, A., Pelligand, L., & Lees, P. (2016). Veterinary Medicine Needs New Green Antimicrobial Drugs. Frontiers in Microbiology, 7, 1196. https://doi.org/10.3389/fmicb.2016.01196

Effect of Cyclooxygenase(COX)-1 and COX-2 inhibition on furosemide-induced renal responses and isoform immunolocalization in the healthy cat kidney (2015)
Journal Article
Pelligand, L., Suemanotham, N., King, J. N., Seewald, W., Syme, H. M., Smith, K. C., Lees, P., & Elliott, J. (2015). Effect of Cyclooxygenase(COX)-1 and COX-2 inhibition on furosemide-induced renal responses and isoform immunolocalization in the healthy cat kidney. BMC Veterinary Research, 11(296), https://doi.org/10.1186/s12917-015-0598-z

Differential pharmacokinetics and pharmacokinetic/pharmacodynamic modelling of robenacoxib and ketoprofen in a feline model of inflammation (2014)
Journal Article
Pelligand, L., King, J. N., Hormazabal, V., Toutain, P. L., Elliott, J., & Lees, P. (2014). Differential pharmacokinetics and pharmacokinetic/pharmacodynamic modelling of robenacoxib and ketoprofen in a feline model of inflammation. Journal of Veterinary Pharmacology and Therapeutics, 37(4), 354-366. https://doi.org/10.1111/jvp.12107

Robenacoxib and ketoprofen are acidic nonsteroidal anti‐inflammatory drugs (NSAIDs). Both are licensed for once daily administration in the cat, despite having short blood half‐lives. This study reports the pharmacokinetic/pharmacodynamic (PK/PD) mod... Read More about Differential pharmacokinetics and pharmacokinetic/pharmacodynamic modelling of robenacoxib and ketoprofen in a feline model of inflammation.

Influence of oxytetracycline on carprofen pharmacodynamics and pharmacokinetics in calves (2013)
Journal Article
Brentnall, C., Cheng, Z. R., McKellar, Q. A., & Lees, P. (2013). Influence of oxytetracycline on carprofen pharmacodynamics and pharmacokinetics in calves. Journal of Veterinary Pharmacology and Therapeutics, 36(4), 320-328. https://doi.org/10.1111/jvp.12000

A tissue cage model of inflammation in calves was used to determine the pharmacokinetic and pharmacodynamic properties of individual carprofen enantiomers, following the administration of the racemate. RS(±) carprofen was administered subcutaneously... Read More about Influence of oxytetracycline on carprofen pharmacodynamics and pharmacokinetics in calves.

Determination of a dosage regimen of colistin by pharmacokinetic/pharmacodynamic integration and modeling for treatment of GIT disease in pigs
Journal Article
Guyonnet, J., Manco, B., Baduel, L., Kaltsatos, V., Aliabadi, M. H. S., & Lees, P. Determination of a dosage regimen of colistin by pharmacokinetic/pharmacodynamic integration and modeling for treatment of GIT disease in pigs. Research in Veterinary Science, 88(2), 307-314. https://doi.org/10.1016/j.rvsc.2009.09.001

Pharmacokinetic and pharmacodynamic integration and modelling of marbofloxacin in calves for Mannheimia haemolytica and Pasteurella multocida
Journal Article
Potter, T. J., Illambas, J., Pelligand, L., Rycroft, A. N., & Lees, P. Pharmacokinetic and pharmacodynamic integration and modelling of marbofloxacin in calves for Mannheimia haemolytica and Pasteurella multocida. https://doi.org/10.1016/j.tvjl.2012.08.027

Age-related differences in prostaglandin E-2 synthesis by equine cartilage explants and synoviocytes
Journal Article
Briston, L., Dudhia, J., & Lees, P. Age-related differences in prostaglandin E-2 synthesis by equine cartilage explants and synoviocytes. Journal of Veterinary Pharmacology and Therapeutics, 33(3), 268-276. https://doi.org/10.1111/j.1365-2885.2009.01131.x

Pharmacokinetic and pharmacodynamic modelling of marbofloxacin administered alone and in combination with tolfenamic acid in calves
Journal Article
Sidhu, P. K., Landoni, M. F., Aliabadi, M. H. S., Toutain, P. L., & Lees, P. Pharmacokinetic and pharmacodynamic modelling of marbofloxacin administered alone and in combination with tolfenamic acid in calves. Journal of Veterinary Pharmacology and Therapeutics, 34(4), 376-387. https://doi.org/10.1111/j.1365-2885.2010.01247.x

Determination of minimum inhibitory and minimum bactericidal concentrations of tiamulin against field isolates of Actinobacillus pleuropneumoniae
Journal Article
Pridmore, A., Burch, D., & Lees, P. Determination of minimum inhibitory and minimum bactericidal concentrations of tiamulin against field isolates of Actinobacillus pleuropneumoniae. Veterinary Microbiology, 151(3-4), 409-412. https://doi.org/10.1016/j.vetmic.2011.03.016

Antimicrobial Resistance in Farm Animals: Origins, Mechanisms, Avoidance, Implications
Journal Article
Potter, T. J., & Lees, P. Antimicrobial Resistance in Farm Animals: Origins, Mechanisms, Avoidance, Implications

Development and validation of a timed urinary collection system for use in the cat.
Journal Article
Pelligand, L., Lees, P., & Elliott, J. Development and validation of a timed urinary collection system for use in the cat. Laboratory Animals, 45(3), 196-203. https://doi.org/10.1258/la.2011.010153

Pharmacology and/or homeopathy
Journal Article
Lees, P. Pharmacology and/or homeopathy. Veterinary Record, 169(14), 368-368. https://doi.org/10.1136/vr.d6243

Robenacoxib in the dog: target species safety in relation to extent and duration of inhibition of COX-1 and COX-2
Journal Article
King, J. N., Arnaud, J. P., Goldenthal, E. I., Gruet, P., Jung, M., Seewald, W., & Lees, P. Robenacoxib in the dog: target species safety in relation to extent and duration of inhibition of COX-1 and COX-2. Journal of Veterinary Pharmacology and Therapeutics, 34(3), 298-311. https://doi.org/10.1111/j.1365-2885.2010.01209.x

Pharmacokinetic/pharmacodynamic modelling of robenacoxib in a feline tissue cage model of inflammation
Journal Article
Pelligand, L., King, J. N., Toutain, P. L., Elliott, J., & Lees, P. Pharmacokinetic/pharmacodynamic modelling of robenacoxib in a feline tissue cage model of inflammation. Journal of Veterinary Pharmacology and Therapeutics, 35(1), 19-32. https://doi.org/10.1111/j.1365-2885.2011.01288.x

Pharmacodynamics of oxytetracycline administered alone and in combination with carprofen in calves
Journal Article
Brentnall, C., Cheng, Z. R., McKellar, Q. A., & Lees, P. Pharmacodynamics of oxytetracycline administered alone and in combination with carprofen in calves. Veterinary Record, 171(11), 273-U59. https://doi.org/10.1136/vr.100935

Establishing bioequivalence of veterinary premixes (Type A medicated articles)
Journal Article
Hunter, R. P., Lees, P., Concordet, D., & Toutain, P. L. Establishing bioequivalence of veterinary premixes (Type A medicated articles). Journal of Veterinary Pharmacology and Therapeutics, 35, 53-63. https://doi.org/10.1111/j.1365-2885.2012.01368.x

Potency and selectivity of carprofen enantiomers for inhibition of bovine cyclooxygenase in whole blood assays
Journal Article
Brentnall, C., Cheng, Z. R., McKellar, Q. A., & Lees, P. Potency and selectivity of carprofen enantiomers for inhibition of bovine cyclooxygenase in whole blood assays. Research in Veterinary Science, 93(3), 1387-92. https://doi.org/10.1016/j.rvsc.2012.05.002

Safety of oral robenacoxib in the cat
Journal Article
King, J. N., Hotz, R., Reagan, E. L., Roth, D. R., Seewald, W., & Lees, P. Safety of oral robenacoxib in the cat. Journal of Veterinary Pharmacology and Therapeutics, 35(3), 290-300. https://doi.org/10.1111/j.1365-2885.2011.01320.x

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