Evolving Value and Validity of Animal Models in Veterinary Therapeutic Research: Impact of Scientific Progress
(2025)
Journal Article
Martinez, M. N., Mochel, J. P., & Toutain, P.-L. (2025). Evolving Value and Validity of Animal Models in Veterinary Therapeutic Research: Impact of Scientific Progress. European Journal of Pharmaceutical Sciences, 107111. https://doi.org/10.1016/j.ejps.2025.107111
All Outputs (3)
Pharmacokinetic–pharmacodynamic cutoff values for doxycycline in pigs to support the establishment of clinical breakpoints for antimicrobial susceptibility testing (2025)
Journal Article
Pelligand, L., Toutain, P.-L., Bouquet-Mélou, A., Ferran, A., Roques, B., del Castillo, J., Lees, P., Croubels, S., & Bousquet, E. (2025). Pharmacokinetic–pharmacodynamic cutoff values for doxycycline in pigs to support the establishment of clinical breakpoints for antimicrobial susceptibility testing. Journal of Veterinary Pharmacology and Therapeutics, https://doi.org/10.1111/jvp.13511This meta-analysis provides a population model of doxycycline (DOXY) disposition in pigs for computation of PK/PD cutoff values corresponding to differing modalities of DOXY administration orally in pigs. This analysis enables establishment of specif... Read More about Pharmacokinetic–pharmacodynamic cutoff values for doxycycline in pigs to support the establishment of clinical breakpoints for antimicrobial susceptibility testing.
Phenotype-Specific Semi-Mechanistic Modelling of Florfenicol Time-Kill Curves in G. parasuis Compared to Other Respiratory Pathogens (2025)
Journal Article
Mead, A., Hughes, A., Azzariti, S., Toutain, P.-L., & Pelligand, L. (2025). Phenotype-Specific Semi-Mechanistic Modelling of Florfenicol Time-Kill Curves in G. parasuis Compared to Other Respiratory Pathogens. Journal of Veterinary Pharmacology and Therapeutics, https://doi.org/10.1111/jvp.13500This study examines the pharmacodynamics (PD) of florfenicol (FFN) for treating porcine respiratory diseases by comparing its effects on Glaesserella parasuis, Actinobacillus pleuropneumoniae, and Pasteurella multocida. In vitro time-kill assays and... Read More about Phenotype-Specific Semi-Mechanistic Modelling of Florfenicol Time-Kill Curves in G. parasuis Compared to Other Respiratory Pathogens.