Skip to main content

Research Repository

Advanced Search

Browse


Decreased nematode clearance & anti-phosphorylcholine specific IgM responses in mannose-binding lectin deficient mice (2018)
Journal Article
Ahmed, R., Cadman, E. T., Snapper, C. M., & Lawrence, R. A. (2018). Decreased nematode clearance & anti-phosphorylcholine specific IgM responses in mannose-binding lectin deficient mice. https://doi.org/10.1111/imcb.12219

Brugia malayi is a nematode that causes human lymphatic filariasis. Previously, we showed that mannose binding lectin (MBL) ?A is necessary for clearance of B. malayi microfilariae in mice and presence of MBL?A is linked with maximal levels of parasi... Read More about Decreased nematode clearance & anti-phosphorylcholine specific IgM responses in mannose-binding lectin deficient mice.

Brugia malayi microfilariae adhere to human vascular endothelial cells in a C3-dependent manner (2017)
Journal Article
Schroeder, H., McCarthy, D., Szestak, T., Cook, D. A., Taylor, M., Craig, A. G., …Lawrence, R. A. (2017). Brugia malayi microfilariae adhere to human vascular endothelial cells in a C3-dependent manner. PLoS Neglected Tropical Diseases, 11(5), e0005592. https://doi.org/10.1371/journal.pntd.0005592

Brugia malayi causes the human tropical disease, lymphatic filariasis. Microfilariae (Mf) of this nematode live in the bloodstream and are ingested by a feeding mosquito vector. Interestingly, in a remarkable co-evolutionary adaptation, Mf appearance... Read More about Brugia malayi microfilariae adhere to human vascular endothelial cells in a C3-dependent manner.

Disorganization of the splenic microanatomy in ageing mice (2016)
Journal Article
Aw, D. P. S., Hilliard, L., Nishikawa, Y., Cadman, E. T., Lawrence, R. A., & Palmer, D. B. (2016). Disorganization of the splenic microanatomy in ageing mice. Immunology, 148(1), 92-101. https://doi.org/10.1111/imm.12590

The precise mechanisms responsible for immunosenescence still remain to be determined, however, considering the evidence that disruption of the organization of primary and secondary lymphoid organs results in immunodeficiency, we propose that this co... Read More about Disorganization of the splenic microanatomy in ageing mice.

Eosinophils Are Important for Protection, Immunoregulation and Pathology during Infection with Nematode Microfilariae (2014)
Journal Article
Cadman, E. T., Thysse, K. A., Bearder, S., Cheung, A. Y. N., Johnston, A. C., Lee, J. J., & Lawrence, R. A. (2014). Eosinophils Are Important for Protection, Immunoregulation and Pathology during Infection with Nematode Microfilariae. PLoS Pathogens, 10(3), e1003988. https://doi.org/10.1371/journal.ppat.1003988

Eosinophil responses typify both allergic and parasitic helminth disease. In helminthic disease, the role of eosinophils can be both protective in immune responses and destructive in pathological responses. To investigate whether eosinophils are invo... Read More about Eosinophils Are Important for Protection, Immunoregulation and Pathology during Infection with Nematode Microfilariae.

Highly homologous Mycobacterium tuberculosis chaperonin 60 proteins with differential CD14 dependencies stimulate cytokine production by human monocytes through cooperative activation of p38 and ERK1/2 mitogen-activated protein kinases
Journal Article
Lewthwaite, J. C., Clarkin, C. E., Coates, A. R. M., Poole, S., Lawrence, R. A., Wheeler-Jones, C. P. D., …Henderson, B. Highly homologous Mycobacterium tuberculosis chaperonin 60 proteins with differential CD14 dependencies stimulate cytokine production by human monocytes through cooperative activation of p38 and ERK1/2 mitogen-activated protein kinases. International Immunopharmacology, 7(2), 230-240. https://doi.org/10.1016/j.intimp.2006.10.005

Altered antibody responses in mannose-binding lectin-A deficient mice do not affect Trichuris muris or Schistosoma mansoni infections
Journal Article
Lawrence, R. A., Carter, T., Bell, L. V., Else, K. J., Summerfield, J., & Bickle, Q. Altered antibody responses in mannose-binding lectin-A deficient mice do not affect Trichuris muris or Schistosoma mansoni infections. Parasite Immunology, 31(2), 104-109. https://doi.org/10.1111/j.1365-3024.2008.01071.x

Parasitic helminths possess surface glycoconjugates that are recognized by the serum collectin molecule, mannose-binding lectin (MBL). Once bound, MBL triggers the lectin pathway of complement. Mice have two MBL, MBL-A and MBL-C. We previously showed... Read More about Altered antibody responses in mannose-binding lectin-A deficient mice do not affect Trichuris muris or Schistosoma mansoni infections.