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All Outputs (34)

Full‐field strain of regenerated bone tissue in a femoral fracture model (2020)
Journal Article
KARALI, A., KAO, A., MEESON, R., ROLDO, M., BLUNN, G., & TOZZI, G. (2020). Full‐field strain of regenerated bone tissue in a femoral fracture model. Journal of Microscopy, https://doi.org/10.1111/jmi.12937

The mechanical behavior of regenerated bone tissue during fracture healing is key in determining its ability to withstand physiological loads. However, the strain distribution in the newly formed tissue and how this influences the way a fracture heal... Read More about Full‐field strain of regenerated bone tissue in a femoral fracture model.

Risk Factors for Canine Osteoarthritis and Its Predisposing Arthropathies: A Systematic Review (2020)
Journal Article
Anderson, K. L., Zulch, H., O'Neill, D. G., Meeson, R. L., & Collins, L. M. (2020). Risk Factors for Canine Osteoarthritis and Its Predisposing Arthropathies: A Systematic Review. Frontiers in Veterinary Science, 7, https://doi.org/10.3389/fvets.2020.00220

Osteoarthritis is a common clinical and pathological end-point from a range of joint disorders, that ultimately lead to structural and functional decline of the joint with associated lameness and pain. Increasing understanding of the risk factors ass... Read More about Risk Factors for Canine Osteoarthritis and Its Predisposing Arthropathies: A Systematic Review.

Epidemiology and clinical management of elbow joint disease in dogs under primary veterinary care in the UK (2020)
Journal Article
O'Neill, D. G., Brodbelt, D. C., Hodge, R., Church, D. B., & Meeson, R. L. (2020). Epidemiology and clinical management of elbow joint disease in dogs under primary veterinary care in the UK. https://doi.org/10.1186/s40575-020-0080-5

Conditions affecting the elbow joint are a common cause of lameness in dogs. Primary-care veterinary clinical data are now recognised as a valuable research resource. Using data from the VetCompass Programme, this study aimed to report the frequency... Read More about Epidemiology and clinical management of elbow joint disease in dogs under primary veterinary care in the UK.

The influence of parathyroid hormone 1-34 on the osteogenic characteristics of adipose- and bone-marrow-derived mesenchymal stem cells from juvenile and ovarectomized rats (2019)
Journal Article
Osagie-Clouard, L., Sanghani-Kerai, A., Coathup, M., Meeson, R., Briggs, T., & Blunn, G. (2019). The influence of parathyroid hormone 1-34 on the osteogenic characteristics of adipose- and bone-marrow-derived mesenchymal stem cells from juvenile and ovarectomized rats. https://doi.org/10.1302/2046-3758.88.BJR-2019-0018.R1

Mesenchymal stem cells (MSCs) are of growing interest in terms of bone regeneration. Most preclinical trials utilize bone-marrow-derived mesenchymal stem cells (bMSCs), although this is not without isolation and expansion difficulties. The aim of thi... Read More about The influence of parathyroid hormone 1-34 on the osteogenic characteristics of adipose- and bone-marrow-derived mesenchymal stem cells from juvenile and ovarectomized rats.

The influence of gap size on the development of fracture union with a micro external fixator (2019)
Journal Article
Meeson, R. L., Moazen, M., Sanghani-Keri, A., Osagie-Clouard, L., Coathup, M., & Blunn, G. (2019). The influence of gap size on the development of fracture union with a micro external fixator. Journal of the Mechanical Behavior of Biomedical Materials, 99, 161-168. https://doi.org/10.1016/j.jmbbm.2019.07.015

Increasingly, the rat femoral fracture model is being used for preclinical investigations of fracture healing, however, the effect of gap size and its influence on mechanobiology is not well understood. We aimed to evaluate the influence of osteotomy... Read More about The influence of gap size on the development of fracture union with a micro external fixator.

VEGF with AMD3100 Endogenously Mobilizes Mesenchymal Stem Cells and Improves Fracture Healing (2019)
Journal Article
Meeson, R. L., Sanghani-Keri, A., Coathup, M., & Blunn, G. (2019). VEGF with AMD3100 Endogenously Mobilizes Mesenchymal Stem Cells and Improves Fracture Healing. Journal of Orthopaedic Research, 37(6), 1294-1302. https://doi.org/10.1002/jor.24164

A significant number of fractures develop non‐union. Mesenchymal stem cell (MSC) therapy may be beneficial, however, this requires cell acquisition, culture and delivery. Endogenous mobilization of stem cells offers a non‐invasive alternative. The hy... Read More about VEGF with AMD3100 Endogenously Mobilizes Mesenchymal Stem Cells and Improves Fracture Healing.

Spontaneous dog osteoarthritis — a One Medicine vision (2019)
Journal Article
Meeson, R. L., Todhunter, R. J., Blunn, G., Nuki, G., & Pitsillides, A. A. (2019). Spontaneous dog osteoarthritis — a One Medicine vision. Nature Reviews Rheumatology, 15(5), 273-287. https://doi.org/10.1038/s41584-019-0202-1

Osteoarthritis (OA) is a global disease that, despite extensive research, has limited treatment options. Pet dogs share both an environment and lifestyle attributes with their owners, and a growing awareness is developing in the public and among rese... Read More about Spontaneous dog osteoarthritis — a One Medicine vision.

CXCR4 Antagonism to Treat Delayed Fracture Healing (2019)
Journal Article
Meeson, R. L., Sanghani, A., Coathup, M., & Blunn, G. (2019). CXCR4 Antagonism to Treat Delayed Fracture Healing. https://doi.org/10.1089/ten.TEA.2018.0265

A significant number of fractures develop non-union. Stem cell homing is regulated through SDF-1 and its receptor CXCR4. Stem/progenitor cell populations can be endogenously mobilised by administering growth factors with a pharmacological antagonist... Read More about CXCR4 Antagonism to Treat Delayed Fracture Healing.

Biomechanics of Two External Fixator Devices Used in Rat Femoral Fractures (2018)
Journal Article
Osagie-Clouard, L., Kaufmann, J., Blunn, G., Coathup, M., Pendegrass, C., Meeson, R. L., Briggs, T., & Moazen, M. (2018). Biomechanics of Two External Fixator Devices Used in Rat Femoral Fractures. Journal of Orthopaedic Research, https://doi.org/10.1002/jor.24034

The use of external fixators allows for the direct investigation of newly formed interfragmentary bone, and the radiographic evaluation of the fracture. We validated the results of a finite element model with the in vitro stiffness' of two widely use... Read More about Biomechanics of Two External Fixator Devices Used in Rat Femoral Fractures.